Correlation of Arterial Stiffness With Left Atrial Volume Index and Left Ventricular Mass Index in Young Adults: Evaluation by Coronary Computed Tomography Angiography

Kazuhiro Osawa, Rine Nakanishi, Toru Miyoshi, Sina Rahmani, Indre Ceponiene, Negin Nezarat, Mitsuru Kanisawa, Hong Qi, Eranthi Jayawardena, Nicholas Kim, Hiroshi Itoh, Matthew J. Budoff

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Increased arterial stiffness is reportedly associated with cardiac remodelling, including the left atrium and left ventricle, in middle-aged and older adults. However, little is known about this association in young adults. Methods: In total, 73 patients (44 (60%) men) aged 25 to 45 years with suspected coronary artery disease were included in the analysis. The left atrial volume index (LAVI), left ventricular volume index (LVVI), and left ventricular mass index (LVMI) were measured using coronary computed tomography angiography (CCTA). Arterial stiffness was assessed with the cardio-ankle vascular index (CAVI). An abnormally high CAVI was defined as that above the age- and sex-specific cut-off points of the CAVI. Results: Compared with patients with a normal CAVI, those with an abnormally high CAVI were older and had a greater prevalence of diabetes mellitus, higher diastolic blood pressure, greater coronary artery calcification score, and a greater LAVI (33.5 ± 10.3 vs. 43.0 ± 10.3 mL/m2, p < 0.01). In contrast, there were no significant differences in the LVVI or LVMI between the subgroups with a normal CAVI and an abnormally high CAVI. Multivariate linear regression analysis showed that the LAVI was significantly associated with an abnormally high CAVI (standardised regression coefficient = 0.283, p = 0.03). Conclusions: The present study demonstrated that increased arterial stiffness is associated with the LAVI, which reflects the early stages of cardiac remodelling, independent of various comorbidity factors in young adults with suspected coronary artery disease.

Original languageEnglish
JournalHeart Lung and Circulation
DOIs
Publication statusAccepted/In press - Jan 1 2018

Fingerprint

Vascular Stiffness
Ankle
Blood Vessels
Young Adult
Coronary Artery Disease
Computed Tomography Angiography
Heart Atria
Heart Ventricles
Comorbidity
Linear Models
Coronary Vessels
Diabetes Mellitus
Regression Analysis
Blood Pressure
Hypertension

Keywords

  • Cardio-ankle vascular index (CAVI)
  • Coronary computed tomography angiography (CCTA)
  • Left atrial volume index (LAVI)
  • Left ventricular mass index (LVMI)
  • Left ventricular volume index (LVVI)

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Correlation of Arterial Stiffness With Left Atrial Volume Index and Left Ventricular Mass Index in Young Adults : Evaluation by Coronary Computed Tomography Angiography. / Osawa, Kazuhiro; Nakanishi, Rine; Miyoshi, Toru; Rahmani, Sina; Ceponiene, Indre; Nezarat, Negin; Kanisawa, Mitsuru; Qi, Hong; Jayawardena, Eranthi; Kim, Nicholas; Itoh, Hiroshi; Budoff, Matthew J.

In: Heart Lung and Circulation, 01.01.2018.

Research output: Contribution to journalArticle

Osawa, Kazuhiro ; Nakanishi, Rine ; Miyoshi, Toru ; Rahmani, Sina ; Ceponiene, Indre ; Nezarat, Negin ; Kanisawa, Mitsuru ; Qi, Hong ; Jayawardena, Eranthi ; Kim, Nicholas ; Itoh, Hiroshi ; Budoff, Matthew J. / Correlation of Arterial Stiffness With Left Atrial Volume Index and Left Ventricular Mass Index in Young Adults : Evaluation by Coronary Computed Tomography Angiography. In: Heart Lung and Circulation. 2018.
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abstract = "Background: Increased arterial stiffness is reportedly associated with cardiac remodelling, including the left atrium and left ventricle, in middle-aged and older adults. However, little is known about this association in young adults. Methods: In total, 73 patients (44 (60{\%}) men) aged 25 to 45 years with suspected coronary artery disease were included in the analysis. The left atrial volume index (LAVI), left ventricular volume index (LVVI), and left ventricular mass index (LVMI) were measured using coronary computed tomography angiography (CCTA). Arterial stiffness was assessed with the cardio-ankle vascular index (CAVI). An abnormally high CAVI was defined as that above the age- and sex-specific cut-off points of the CAVI. Results: Compared with patients with a normal CAVI, those with an abnormally high CAVI were older and had a greater prevalence of diabetes mellitus, higher diastolic blood pressure, greater coronary artery calcification score, and a greater LAVI (33.5 ± 10.3 vs. 43.0 ± 10.3 mL/m2, p < 0.01). In contrast, there were no significant differences in the LVVI or LVMI between the subgroups with a normal CAVI and an abnormally high CAVI. Multivariate linear regression analysis showed that the LAVI was significantly associated with an abnormally high CAVI (standardised regression coefficient = 0.283, p = 0.03). Conclusions: The present study demonstrated that increased arterial stiffness is associated with the LAVI, which reflects the early stages of cardiac remodelling, independent of various comorbidity factors in young adults with suspected coronary artery disease.",
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T1 - Correlation of Arterial Stiffness With Left Atrial Volume Index and Left Ventricular Mass Index in Young Adults

T2 - Evaluation by Coronary Computed Tomography Angiography

AU - Osawa, Kazuhiro

AU - Nakanishi, Rine

AU - Miyoshi, Toru

AU - Rahmani, Sina

AU - Ceponiene, Indre

AU - Nezarat, Negin

AU - Kanisawa, Mitsuru

AU - Qi, Hong

AU - Jayawardena, Eranthi

AU - Kim, Nicholas

AU - Itoh, Hiroshi

AU - Budoff, Matthew J.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: Increased arterial stiffness is reportedly associated with cardiac remodelling, including the left atrium and left ventricle, in middle-aged and older adults. However, little is known about this association in young adults. Methods: In total, 73 patients (44 (60%) men) aged 25 to 45 years with suspected coronary artery disease were included in the analysis. The left atrial volume index (LAVI), left ventricular volume index (LVVI), and left ventricular mass index (LVMI) were measured using coronary computed tomography angiography (CCTA). Arterial stiffness was assessed with the cardio-ankle vascular index (CAVI). An abnormally high CAVI was defined as that above the age- and sex-specific cut-off points of the CAVI. Results: Compared with patients with a normal CAVI, those with an abnormally high CAVI were older and had a greater prevalence of diabetes mellitus, higher diastolic blood pressure, greater coronary artery calcification score, and a greater LAVI (33.5 ± 10.3 vs. 43.0 ± 10.3 mL/m2, p < 0.01). In contrast, there were no significant differences in the LVVI or LVMI between the subgroups with a normal CAVI and an abnormally high CAVI. Multivariate linear regression analysis showed that the LAVI was significantly associated with an abnormally high CAVI (standardised regression coefficient = 0.283, p = 0.03). Conclusions: The present study demonstrated that increased arterial stiffness is associated with the LAVI, which reflects the early stages of cardiac remodelling, independent of various comorbidity factors in young adults with suspected coronary artery disease.

AB - Background: Increased arterial stiffness is reportedly associated with cardiac remodelling, including the left atrium and left ventricle, in middle-aged and older adults. However, little is known about this association in young adults. Methods: In total, 73 patients (44 (60%) men) aged 25 to 45 years with suspected coronary artery disease were included in the analysis. The left atrial volume index (LAVI), left ventricular volume index (LVVI), and left ventricular mass index (LVMI) were measured using coronary computed tomography angiography (CCTA). Arterial stiffness was assessed with the cardio-ankle vascular index (CAVI). An abnormally high CAVI was defined as that above the age- and sex-specific cut-off points of the CAVI. Results: Compared with patients with a normal CAVI, those with an abnormally high CAVI were older and had a greater prevalence of diabetes mellitus, higher diastolic blood pressure, greater coronary artery calcification score, and a greater LAVI (33.5 ± 10.3 vs. 43.0 ± 10.3 mL/m2, p < 0.01). In contrast, there were no significant differences in the LVVI or LVMI between the subgroups with a normal CAVI and an abnormally high CAVI. Multivariate linear regression analysis showed that the LAVI was significantly associated with an abnormally high CAVI (standardised regression coefficient = 0.283, p = 0.03). Conclusions: The present study demonstrated that increased arterial stiffness is associated with the LAVI, which reflects the early stages of cardiac remodelling, independent of various comorbidity factors in young adults with suspected coronary artery disease.

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KW - Coronary computed tomography angiography (CCTA)

KW - Left atrial volume index (LAVI)

KW - Left ventricular mass index (LVMI)

KW - Left ventricular volume index (LVVI)

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