Abstract
PURPOSE. To evaluate relationships between the macular visual field (VF) mean sensitivity and the ganglion cell and inner plexiform layer (GCA) thicknesses. METHODS. Seventy-one glaucoma patients and 29 healthy subjects were included in this crosssectional study. At each visit, GCA thicknesses were measured by Cirrus HD-OCT and static threshold perimetry was performed using Macular Integrity Assessment (MAIA). The relationship between the VF sensitivity and GCA thickness was examined globally, and in the superior hemiretina, inferior hemiretina, and six VF sectors with both VF and optical coherence tomography (OCT) in retinal view. Regression analysis was used to investigate the relationship between the GCA thickness and macular sensitivity. RESULTS. Macular VF sensitivity (dB) and GCA thickness relationships were statistically significant in each sector (R = 0.365-0.706, all P <0.001). The highest correlation observed was between the inferotemporal average mean sensitivity and the inferotemporal average GCA thickness (R = 0.706) with both VF and OCT in retinal view. Strength of the structure- function relationship for each of the corresponding inferior sectors was higher than those for the corresponding superior sectors. The strength of the structure-function relationship of the temporal sector was higher than that of the nasal sector. CONCLUSIONS. GCA thickness measured by Cirrus HD-OCT showed statistically significant structure-function associations with central VF. Inferotemporal central VF had the strongest association.
| Original language | English |
|---|---|
| Pages (from-to) | 3046-3051 |
| Number of pages | 6 |
| Journal | Investigative Ophthalmology and Visual Science |
| Volume | 54 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 11 2013 |
| Externally published | Yes |
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Keywords
- Microperimetry
- Optical coherence tomography
- Visual field
ASJC Scopus subject areas
- Ophthalmology
- Sensory Systems
- Cellular and Molecular Neuroscience
Cite this
Correlation between the ganglion cell-inner plexiform layer thickness measured with cirrus HD-OCT and macular visual field sensitivity measured with microperimetry. / Sato, Shino; Hirooka, Kazuyuki; Baba, Tetsuya; Tenkumo, Kaori; Nitta, Eri; Shiraga, Fumio.
In: Investigative Ophthalmology and Visual Science, Vol. 54, No. 4, 11.04.2013, p. 3046-3051.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Correlation between the ganglion cell-inner plexiform layer thickness measured with cirrus HD-OCT and macular visual field sensitivity measured with microperimetry
AU - Sato, Shino
AU - Hirooka, Kazuyuki
AU - Baba, Tetsuya
AU - Tenkumo, Kaori
AU - Nitta, Eri
AU - Shiraga, Fumio
PY - 2013/4/11
Y1 - 2013/4/11
N2 - PURPOSE. To evaluate relationships between the macular visual field (VF) mean sensitivity and the ganglion cell and inner plexiform layer (GCA) thicknesses. METHODS. Seventy-one glaucoma patients and 29 healthy subjects were included in this crosssectional study. At each visit, GCA thicknesses were measured by Cirrus HD-OCT and static threshold perimetry was performed using Macular Integrity Assessment (MAIA). The relationship between the VF sensitivity and GCA thickness was examined globally, and in the superior hemiretina, inferior hemiretina, and six VF sectors with both VF and optical coherence tomography (OCT) in retinal view. Regression analysis was used to investigate the relationship between the GCA thickness and macular sensitivity. RESULTS. Macular VF sensitivity (dB) and GCA thickness relationships were statistically significant in each sector (R = 0.365-0.706, all P <0.001). The highest correlation observed was between the inferotemporal average mean sensitivity and the inferotemporal average GCA thickness (R = 0.706) with both VF and OCT in retinal view. Strength of the structure- function relationship for each of the corresponding inferior sectors was higher than those for the corresponding superior sectors. The strength of the structure-function relationship of the temporal sector was higher than that of the nasal sector. CONCLUSIONS. GCA thickness measured by Cirrus HD-OCT showed statistically significant structure-function associations with central VF. Inferotemporal central VF had the strongest association.
AB - PURPOSE. To evaluate relationships between the macular visual field (VF) mean sensitivity and the ganglion cell and inner plexiform layer (GCA) thicknesses. METHODS. Seventy-one glaucoma patients and 29 healthy subjects were included in this crosssectional study. At each visit, GCA thicknesses were measured by Cirrus HD-OCT and static threshold perimetry was performed using Macular Integrity Assessment (MAIA). The relationship between the VF sensitivity and GCA thickness was examined globally, and in the superior hemiretina, inferior hemiretina, and six VF sectors with both VF and optical coherence tomography (OCT) in retinal view. Regression analysis was used to investigate the relationship between the GCA thickness and macular sensitivity. RESULTS. Macular VF sensitivity (dB) and GCA thickness relationships were statistically significant in each sector (R = 0.365-0.706, all P <0.001). The highest correlation observed was between the inferotemporal average mean sensitivity and the inferotemporal average GCA thickness (R = 0.706) with both VF and OCT in retinal view. Strength of the structure- function relationship for each of the corresponding inferior sectors was higher than those for the corresponding superior sectors. The strength of the structure-function relationship of the temporal sector was higher than that of the nasal sector. CONCLUSIONS. GCA thickness measured by Cirrus HD-OCT showed statistically significant structure-function associations with central VF. Inferotemporal central VF had the strongest association.
KW - Microperimetry
KW - Optical coherence tomography
KW - Visual field
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U2 - 10.1167/iovs.12-11173
DO - 10.1167/iovs.12-11173
M3 - Article
VL - 54
SP - 3046
EP - 3051
JO - Investigative Ophthalmology and Visual Science
JF - Investigative Ophthalmology and Visual Science
SN - 0146-0404
IS - 4
ER -