Correlation between 18F-fuorodeoxyglucose positron emission tomography/computed tomography and clinicopathological features in invasive ductal carcinoma of the breast

Maiko Ito, Tadahiko Shien, Mitsumasa Kaji, Taeko Mizoo, Takayuki Iwamoto, Tomohiro Nogami, Takayuki Motoki, Naruto Taira, Hiroyoshi Doihara, Shinichiro Miyoshi

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


We evaluated the usefulness of preoperative 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) examinations to predict the pathological features in primary breast cancer. In particular, we evaluated the correlation between the maximum standardized uptake values (SUVmax) obtained by 18F-FDG PET/CT and the Ki67 expression in estrogen receptor (Expositive invasive ductal carcinoma (IDC). Primary IDC patients operated between March 2009 and July 2013 at Okayama University Hospital were enrolled. We evaluated the correlations between the SUVmax and age, postoperative pT, histological grade, lymph vascular invasion, status of hormone receptor, human epidermal growth factor receptor 2 (HER2), Ki67 expression and node status. The Ki67 expression was classified as high (> 14%) versus low (≤ 14%). We enrolled 138 patients with IDC. Their median SUVmax was 3.85 (range: 0-52.57). In a univariate analysis, the SUVmax was significantly related to age, pT, histological grade, lymphovascular invasion, hormone receptor status, HER2 status, node status and Ki67. In the 113 patients with ER-positive IDC, there was a significant correlation between Ki67 and SUVmax (p = 0.0030). The preoperative 18F-FDG PET/CT results of IDC patients had significant relationships with pathological status parameters. The determination of the preoperative SUVmax might help classify Luminal A and Luminal B patients among luminal-type breast cancer patients.

Original languageEnglish
Pages (from-to)333-338
Number of pages6
JournalActa medica Okayama
Issue number6
Publication statusPublished - 2015


  • Breast cancer
  • Clinicopathological features
  • F-fluorodeoxyglucose positron emission tomography/computed tomography
  • Invasive ductal carcinoma
  • Maximum standardized uptake values

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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