Correlation between serum cholesterols and trace element uptake in liver, kidney, and blood of hypercholesterolemic mice

Rajiv G. Weginwar, Shuichi Enomoto, Rieko Hirunuma, Shizuko Ambe

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The radioactive multitracer technique was applied to the simultaneous determination of the uptake of 17 trace elements (Be, Na, Sc, V, Cr, Mn, Fe, Co, Zn, As, Se, Rb, Sr, Y, Zr, Nb, and Ru) in the liver, kidney, and blood of hypercholesterolemic model mice. The uptakes of Be, Sc, V, Cr, Fe, As, Rb, Y, Zr, Nb, and Ru in liver increased with an increasing feeding period of a cholesterol-rich diet, whereas the uptakes of Zn and Se decreased. Feeding of the diet resulted in a marked increase in serum total cholesterol, triglycerides, and low-density lipoprotein cholesterol. The metabolism of trace elements between cholesterolemic and normal mice was compared with respect to their serum cholesterol levels. A significant positive correlation was found between the concentration of serum triglycerides and liver uptakes of Cr, Fe, and As and a negative correlation for the uptake of Zn. A significant positive correlation was found between the concentrations of serum high- and low-density lipoprotein cholesterols and kidney uptakes of Cr and Rb. A negative correlation was found between the uptake of Be in the blood and the concentration of serum triglycerides. These results suggest that cholesterolemia have some specific effects on the metabolism of some elements.

Original languageEnglish
Pages (from-to)249-268
Number of pages20
JournalBiological Trace Element Research
Volume86
Issue number3
DOIs
Publication statusPublished - Jan 1 2002

Keywords

  • Cholesterols
  • Correlation
  • Hypercholesterolemic mice
  • Multitracer
  • Trace element
  • Uptake

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical
  • Inorganic Chemistry

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