Correlation between hydrophobic attraction and the free energy of hydrophobic hydration

Kenichiro Koga, P. Bhimalapuram, B. Widom

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We correlate the strength of the solvent-mediated attraction of a pair of hydrophobic solute molecules with the free energy of hydration of a single such molecule. This is done in the framework of a particular model but the results may be more general. When the model parameters are chosen to represent methane as the solute in water it is found that over the relevant temperature range the strength of the attraction, expressed as a multiple of the thermal energy kT, increases nearly linearly with increasing hydration free energy expressed in the same units. In the middle of the temperature range studied the strength of the attraction is roughly one-third of the hydration free energy.

Original languageEnglish
Pages (from-to)3795-3801
Number of pages7
JournalMolecular Physics
Volume100
Issue number24
DOIs
Publication statusPublished - Dec 20 2002
Externally publishedYes

Fingerprint

Hydration
Free energy
attraction
hydration
free energy
Temperature
Methane
solutes
Molecules
Hot Temperature
Thermal energy
thermal energy
Water
molecules
methane
temperature
water

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

Correlation between hydrophobic attraction and the free energy of hydrophobic hydration. / Koga, Kenichiro; Bhimalapuram, P.; Widom, B.

In: Molecular Physics, Vol. 100, No. 24, 20.12.2002, p. 3795-3801.

Research output: Contribution to journalArticle

Koga, Kenichiro ; Bhimalapuram, P. ; Widom, B. / Correlation between hydrophobic attraction and the free energy of hydrophobic hydration. In: Molecular Physics. 2002 ; Vol. 100, No. 24. pp. 3795-3801.
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