Coronary angioscopic findings eight months after sirolimus-eluting stent implantation: A comparison between ST-elevation myocardial infarction and stable angina pectoris

Kazuoki Dai, Masaharu Ishihara, Ichiro Inoue, Takuji Kawagoe, Yuji Shimatani, Satoshi Kurisu, Yasuharu Nakama, Tatsuya Maruhashi, Eisuke Kagawa, Toshiyuki Aokage, Junichi Matsushita, Ikenaga Hiroki

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Aims: Conflicting data exist about the safety of the sirolimus-eluting stent (SES) for patients with ST-elevation myocardial infarction (STEMI). Previous studies have reported delayed neointimal proliferation over SES with high incidence of adhering thrombus. This study was undertaken to assess the neointimal coverage and thrombus formation after SES implantation between patients with STEMI and those with stable angina pectoris (SAP). Methods and results: We studied 23 patients with STEMI who underwent primary percutaneous coronary intervention (PCI) with SES and 18 patients with SAP who were treated with SES. Coronary angioscopic examination was performed 8.1±2.4 months after PCI. Neointimal coverage of the stent was classified into four grades (grade 0 to 3). Uncovered stent strut was defined as grade 0 or 1. All the patients with STEMI and 94% of patients with SAP had uncovered stent struts. There was no significant difference in minimum, maximum, and dominant neointimal coverage grade between STEMI and SAP. 96% of patients with STEMI and all the patients with SAP showed heterogeneous neointimal coverage. Thrombus adhering to uncovered stent struts was observed in eight patients after STEMI and in four patients after SAP (35% vs. 22%, p=0.38). There was no significant difference in the maximum colour grade of the plaques between STEMI and SAP (2.1±0.8 vs. 1.8±0.9, p=0.33). Most thrombus was observed at the site of yellow plaques (83%). Conclusions: There was no significant difference in the neointimal coverage and thrombus formation between STEMI and SAP.

Original languageEnglish
Pages (from-to)251-256
Number of pages6
JournalEuroIntervention
Volume6
Issue number2
DOIs
Publication statusPublished - Jun 1 2010
Externally publishedYes

Fingerprint

Stable Angina
Sirolimus
Stents
Thrombosis
Percutaneous Coronary Intervention
ST Elevation Myocardial Infarction
Color
Safety

Keywords

  • Acute myocardial infarction
  • Coronary angioscopy
  • Stable angina pectoris

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Coronary angioscopic findings eight months after sirolimus-eluting stent implantation : A comparison between ST-elevation myocardial infarction and stable angina pectoris. / Dai, Kazuoki; Ishihara, Masaharu; Inoue, Ichiro; Kawagoe, Takuji; Shimatani, Yuji; Kurisu, Satoshi; Nakama, Yasuharu; Maruhashi, Tatsuya; Kagawa, Eisuke; Aokage, Toshiyuki; Matsushita, Junichi; Hiroki, Ikenaga.

In: EuroIntervention, Vol. 6, No. 2, 01.06.2010, p. 251-256.

Research output: Contribution to journalArticle

Dai, K, Ishihara, M, Inoue, I, Kawagoe, T, Shimatani, Y, Kurisu, S, Nakama, Y, Maruhashi, T, Kagawa, E, Aokage, T, Matsushita, J & Hiroki, I 2010, 'Coronary angioscopic findings eight months after sirolimus-eluting stent implantation: A comparison between ST-elevation myocardial infarction and stable angina pectoris', EuroIntervention, vol. 6, no. 2, pp. 251-256. https://doi.org/10.4244/EIJV6I2A40
Dai, Kazuoki ; Ishihara, Masaharu ; Inoue, Ichiro ; Kawagoe, Takuji ; Shimatani, Yuji ; Kurisu, Satoshi ; Nakama, Yasuharu ; Maruhashi, Tatsuya ; Kagawa, Eisuke ; Aokage, Toshiyuki ; Matsushita, Junichi ; Hiroki, Ikenaga. / Coronary angioscopic findings eight months after sirolimus-eluting stent implantation : A comparison between ST-elevation myocardial infarction and stable angina pectoris. In: EuroIntervention. 2010 ; Vol. 6, No. 2. pp. 251-256.
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abstract = "Aims: Conflicting data exist about the safety of the sirolimus-eluting stent (SES) for patients with ST-elevation myocardial infarction (STEMI). Previous studies have reported delayed neointimal proliferation over SES with high incidence of adhering thrombus. This study was undertaken to assess the neointimal coverage and thrombus formation after SES implantation between patients with STEMI and those with stable angina pectoris (SAP). Methods and results: We studied 23 patients with STEMI who underwent primary percutaneous coronary intervention (PCI) with SES and 18 patients with SAP who were treated with SES. Coronary angioscopic examination was performed 8.1±2.4 months after PCI. Neointimal coverage of the stent was classified into four grades (grade 0 to 3). Uncovered stent strut was defined as grade 0 or 1. All the patients with STEMI and 94{\%} of patients with SAP had uncovered stent struts. There was no significant difference in minimum, maximum, and dominant neointimal coverage grade between STEMI and SAP. 96{\%} of patients with STEMI and all the patients with SAP showed heterogeneous neointimal coverage. Thrombus adhering to uncovered stent struts was observed in eight patients after STEMI and in four patients after SAP (35{\%} vs. 22{\%}, p=0.38). There was no significant difference in the maximum colour grade of the plaques between STEMI and SAP (2.1±0.8 vs. 1.8±0.9, p=0.33). Most thrombus was observed at the site of yellow plaques (83{\%}). Conclusions: There was no significant difference in the neointimal coverage and thrombus formation between STEMI and SAP.",
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AU - Ishihara, Masaharu

AU - Inoue, Ichiro

AU - Kawagoe, Takuji

AU - Shimatani, Yuji

AU - Kurisu, Satoshi

AU - Nakama, Yasuharu

AU - Maruhashi, Tatsuya

AU - Kagawa, Eisuke

AU - Aokage, Toshiyuki

AU - Matsushita, Junichi

AU - Hiroki, Ikenaga

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N2 - Aims: Conflicting data exist about the safety of the sirolimus-eluting stent (SES) for patients with ST-elevation myocardial infarction (STEMI). Previous studies have reported delayed neointimal proliferation over SES with high incidence of adhering thrombus. This study was undertaken to assess the neointimal coverage and thrombus formation after SES implantation between patients with STEMI and those with stable angina pectoris (SAP). Methods and results: We studied 23 patients with STEMI who underwent primary percutaneous coronary intervention (PCI) with SES and 18 patients with SAP who were treated with SES. Coronary angioscopic examination was performed 8.1±2.4 months after PCI. Neointimal coverage of the stent was classified into four grades (grade 0 to 3). Uncovered stent strut was defined as grade 0 or 1. All the patients with STEMI and 94% of patients with SAP had uncovered stent struts. There was no significant difference in minimum, maximum, and dominant neointimal coverage grade between STEMI and SAP. 96% of patients with STEMI and all the patients with SAP showed heterogeneous neointimal coverage. Thrombus adhering to uncovered stent struts was observed in eight patients after STEMI and in four patients after SAP (35% vs. 22%, p=0.38). There was no significant difference in the maximum colour grade of the plaques between STEMI and SAP (2.1±0.8 vs. 1.8±0.9, p=0.33). Most thrombus was observed at the site of yellow plaques (83%). Conclusions: There was no significant difference in the neointimal coverage and thrombus formation between STEMI and SAP.

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KW - Stable angina pectoris

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