Corneal perforation in two cases of connective tissue disease during treatment with peroral nonsteroidal anti-inflammatory drug

Ikuya Masuda, Toshihiko Matsuo, Kyoko Matsushita, Kazuo Okamoto, Hiroshi Ohtsuki

Research output: Contribution to journalArticle

Abstract

Purpose : To report 2 cases of collagen disease who developed corneal melting and perforation during peroral treatment with nonsteroidal anti-inflammatory drug (NSAID). Cases : Both were females aged 62 and 79 years respectively. One case had been diagnosed with mixed connective tissue disease with systemic lupus erythematosus, scleroderma, polymyositis, and Sjöegren syndrome 30 years before. She had been receiving peroral prednisolone since 20 years before. She had been diagnosed with herpes zoster and herpetic keratoiritis 2 weeks before followed by peral tiaprofenic acid. The other case had been diagnosed with rheumatic arthritis 40 years before and had been receiving acetylsalicylic acid for 5 months. Findings : Both cases developed unilateral corneal perforation. The perforation became epithelialized with formation of anterior chamber 14 and 10 days respectively after discontinuation of NSAID. Conclusion : There is a possibility that peroral NSAID may result in corneal melting and perforation.

Original languageEnglish
Pages (from-to)1931-1934
Number of pages4
JournalJapanese Journal of Clinical Ophthalmology
Volume61
Issue number10
Publication statusPublished - 2007

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Corneal Perforation
Connective Tissue Diseases
Anti-Inflammatory Agents
Freezing
Pharmaceutical Preparations
Mixed Connective Tissue Disease
Polymyositis
Collagen Diseases
Rheumatic Fever
Herpes Zoster
Anterior Chamber
Prednisolone
Systemic Lupus Erythematosus
Aspirin
Therapeutics

ASJC Scopus subject areas

  • Ophthalmology

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Corneal perforation in two cases of connective tissue disease during treatment with peroral nonsteroidal anti-inflammatory drug. / Masuda, Ikuya; Matsuo, Toshihiko; Matsushita, Kyoko; Okamoto, Kazuo; Ohtsuki, Hiroshi.

In: Japanese Journal of Clinical Ophthalmology, Vol. 61, No. 10, 2007, p. 1931-1934.

Research output: Contribution to journalArticle

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