Copper-catalyzed regioselective chloroamination of alkenes with chlorotrimethylsilane and n-fluorobenzenesulfonimide under microwave-assisted conditions

Masayuki Iwasaki, Jie Xu, Yukari Tani, Liyan Fu, Yuichi Ikemoto, Yasuyuki Ura, Yasushi Nishihara

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A copper-catalyzed chloroamination of alkenes with chlorotrimethylsilane and N-fluorobenzenesulfonimide has been developed. The reactions were complete within 1 h at 120 °C by means of microwave heating. The present chloroamination proceeds with a perfect regioselectivity and is compatible with various functional groups. The preliminary mechanistic investigation revealed that the reaction involves a radical process. The utility of the present method was demonstrated by scalable, operationally simple and safe system.

Original languageEnglish
Pages (from-to)281-284
Number of pages4
JournalChemistry Letters
Volume48
Issue number3
DOIs
Publication statusPublished - 2019

Keywords

  • Alkenes
  • Chloroamination
  • Copper catalyst

ASJC Scopus subject areas

  • Chemistry(all)

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