Conversion of cephem into penam/penem through sequential ring-opening/recyclization in an Al/BiCl3/AlCl3 system

Hideo Tanaka, Yoshihisa Tokumaru, Yutaka Kameyama, Sigeru Torii

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A sequential reductive ring-opening/recyclization reaction of 3-substituted Δ3-cephems into 2-exco-methylenepenams and/or 2-methylpenems was successfully performed by treatment with Al/BiCl3/AlCl3 in NMP (N-methyl-2-pyrrolidinone). When the reaction was carried out in methanol, 3-norcephalosporin was formed as a major product.

Original languageEnglish
Pages (from-to)1221-1222
Number of pages2
JournalChemistry Letters
Issue number12
Publication statusPublished - 1997


ASJC Scopus subject areas

  • Chemistry(all)

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