A sequential reductive ring-opening/recyclization reaction of 3-substituted Δ3-cephems into 2-exco-methylenepenams and/or 2-methylpenems was successfully performed by treatment with Al/BiCl3/AlCl3 in NMP (N-methyl-2-pyrrolidinone). When the reaction was carried out in methanol, 3-norcephalosporin was formed as a major product.
|Number of pages||2|
|Publication status||Published - 1997|
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