Convergent synthesis of the HIJKLM ring system of ciguatoxin CTX3C

Hiroyoshi Takamura; Naoki Nishiuma; Takashi Abe; Isao Kadota

doi:10.1021/ol2019136

Convergent synthesis of the HIJKLM ring system of ciguatoxin CTX3C

Hiroyoshi Takamura, Naoki Nishiuma, Takashi Abe, Isao Kadota

Research output: Contribution to journal › Article

10 Citations (Scopus)

Abstract

The HIJKLM ring system of ciguatoxin CTX3C was synthesized in a convergent manner. The key steps were a conjugate addition/alkylation sequence, spiroacetalization, intramolecular allylation, ring-closing metathesis, and hydrogenation to form the 36-α-methyl substituent.

Original language	English
Pages (from-to)	4704-4707
Number of pages	4
Journal	Organic Letters
Volume	13
Issue number	17
DOIs	https://doi.org/10.1021/ol2019136
Publication status	Published - Sep 2 2011

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ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

Cite this

Takamura, H., Nishiuma, N., Abe, T., & Kadota, I. (2011). Convergent synthesis of the HIJKLM ring system of ciguatoxin CTX3C. Organic Letters, 13(17), 4704-4707. https://doi.org/10.1021/ol2019136

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Access to Document

10.1021/ol2019136