Convergent synthesis of the HIJKLM ring system of ciguatoxin CTX3C

Hiroyoshi Takamura, Naoki Nishiuma, Takashi Abe, Isao Kadota

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The HIJKLM ring system of ciguatoxin CTX3C was synthesized in a convergent manner. The key steps were a conjugate addition/alkylation sequence, spiroacetalization, intramolecular allylation, ring-closing metathesis, and hydrogenation to form the 36-α-methyl substituent.

Original languageEnglish
Pages (from-to)4704-4707
Number of pages4
JournalOrganic Letters
Volume13
Issue number17
DOIs
Publication statusPublished - Sep 2 2011

Fingerprint

Allylation
Hydrogenation
Alkylation
metathesis
rings
alkylation
closing
synthesis
hydrogenation
ciguatoxin 3C

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

Cite this

Convergent synthesis of the HIJKLM ring system of ciguatoxin CTX3C. / Takamura, Hiroyoshi; Nishiuma, Naoki; Abe, Takashi; Kadota, Isao.

In: Organic Letters, Vol. 13, No. 17, 02.09.2011, p. 4704-4707.

Research output: Contribution to journalArticle

Takamura, Hiroyoshi ; Nishiuma, Naoki ; Abe, Takashi ; Kadota, Isao. / Convergent synthesis of the HIJKLM ring system of ciguatoxin CTX3C. In: Organic Letters. 2011 ; Vol. 13, No. 17. pp. 4704-4707.
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