Convergence of hepatoportal glucose-sensitive afferent signals to glucose-sensitive units within the nucleus of the solitary tract

A. Adachi, N. Shimizu, Y. Oomura, Motoi Kobashi

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Abstract

Units which are activated by ascending impulses from the liver within the nucleus of the solitary tract (NTS) were identified by electrical stimulation delivered to the hepatic branch of the vagus. Responses of descending units were eliminated by a collision test. The units which showed decreased firing rates during portal infusion of isotonic glucose solution were also glucose-sensitive so that they showed decreased firing rates during topical application of glucose by means of micro-electro-osmotic techniques. It is concluded that glucose-sensitive neurons exist within the NTS and also that they are functionally linked with hepatoportal glucose-sensitive afferent units.

Original languageEnglish
Pages (from-to)215-218
Number of pages4
JournalNeuroscience Letters
Volume46
Issue number2
DOIs
Publication statusPublished - May 4 1984

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Keywords

  • chemoresponsive neuron
  • hepatic afferent
  • NTS
  • vagus nerve

ASJC Scopus subject areas

  • Neuroscience(all)

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