Convergence of gastric and hepatic information in brain stem neurons of the rat

Guillermo Chambert, Motoi Kobashi, Akira Adachi

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Convergence of gastric and hepatic information in the nucleus of the solitary tract (NTS) was investigated by single-pulse electrical stimulation of the hepatic and the gastric branches of the vagus. Facilitation induced by both stimuli occurred most often in responses of neurons in the NTS, indicating convergence of information there. In a second experiment using gastric distension and portal infusion of glucose to analyze such convergence, activation by gastric distension and suppression by portal glucose was the most prominent combination of responses to both stimuli. This confirmed the results of electrical stimulation, because distension increases the firing rate of gastric afferents and glucose infusion decreases the firing rate of hepatic afferents. Analysis of the responses to varying degrees of gastric distension revealed that some NTS neurons are activated by weak distension, but inhibited by strong distensions.

Original languageEnglish
Pages (from-to)525-529
Number of pages5
JournalBrain Research Bulletin
Volume32
Issue number5
DOIs
Publication statusPublished - 1993

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Brain Stem
Stomach
Neurons
Liver
Glucose
Electric Stimulation
Solitary Nucleus

Keywords

  • Dorsal motor nucleus of the vagus
  • Gastric distension
  • Gastric mechanoreceptors
  • Gastric vagus
  • Hepatic glucoreceptors
  • Hepatic vagus
  • Nucleus of the solitary tract

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Convergence of gastric and hepatic information in brain stem neurons of the rat. / Chambert, Guillermo; Kobashi, Motoi; Adachi, Akira.

In: Brain Research Bulletin, Vol. 32, No. 5, 1993, p. 525-529.

Research output: Contribution to journalArticle

Chambert, Guillermo ; Kobashi, Motoi ; Adachi, Akira. / Convergence of gastric and hepatic information in brain stem neurons of the rat. In: Brain Research Bulletin. 1993 ; Vol. 32, No. 5. pp. 525-529.
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