Abstract
Reaction of salicylaldehydes (1) with carbethoxymethylenetriphenylphosphorane in diethylaniline under reflux gave coumarins (3) in moderate to high yield except 3-methoxycarbonylsalicylaldehyde (le) as summarized in Table I. The substituent effects are discussed. A substituent at C6 on 1 usually facilitated the formation of the coumarin ring regardless of its electronic character.
Original language | English |
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Pages (from-to) | 2170-2173 |
Number of pages | 4 |
Journal | Chemical and Pharmaceutical Bulletin |
Volume | 42 |
Issue number | 10 |
DOIs | |
Publication status | Published - 1994 |
Keywords
- Keywords salicylaldehyde
- Wittig reaction
- bromocoumarin
- coumarin synthesis
- methoxycarbonyl-coumarin
- substituent effect
ASJC Scopus subject areas
- Chemistry(all)
- Drug Discovery