Controlled release of a protein using a ceramic carrier and zinc ions as a novel approach to the treatment of osteoporosis

H. Watanabe, T. Ikoma, M. Tanaka, T. Yoshioka, J. Tanaka

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Injectable formulations with systemically or locally controlled release of protein drugs have been required to ameliorate their efficacy and reduce adverse effects. In this paper, the release properties of osteoprotegerin (OPG) from hydroxyapatite / chondroitin sulfate (HAp/ChS) microparticles were described. The formulation was produced by subsequent addition of zinc chloride solution into a mixture of HAp/ChS microparticles and OPG solution. The release of OPG from the formulation in PBS was positively correlated with soaking time without any initial burst release. The release rate decreased with an increased amount of zinc cations, which did not depend on ChS wt% in the microparticles. The controlled release of OPG could provide an improvement of drug delivery and a reduction of adverse effects associated with the use of antiresortive agents.

Original languageEnglish
Title of host publicationBioceramics 26
EditorsMaria-Pau Ginebra, Cristina Canal, Montserrat Espanol, Edgar B. Montufar, Roman A. Perez
PublisherTrans Tech Publications Ltd
Pages332-337
Number of pages6
ISBN (Electronic)9783038352822
DOIs
Publication statusPublished - Jan 1 2015
Externally publishedYes
Event26th Symposium and Annual Meeting of the International Society for Ceramics in Medicine, ISCM 2014 - Barcelona, Spain
Duration: Nov 6 2014Nov 8 2014

Publication series

NameKey Engineering Materials
Volume631
ISSN (Print)1013-9826
ISSN (Electronic)1662-9795

Other

Other26th Symposium and Annual Meeting of the International Society for Ceramics in Medicine, ISCM 2014
CountrySpain
CityBarcelona
Period11/6/1411/8/14

Keywords

  • Chondroitin sulfate
  • Controlled release
  • Hydroxyapatite
  • Osteoporosis
  • Osteoprotegerin
  • Zinc

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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