Contribution of pharmaceuticals and personal care products (PPCPs) to whole toxicity of water samples collected in effluent-dominated urban streams

Ikumi Tamura, Yusuke Yasuda, Kei ichiro Kagota, Saori Yoneda, Norihide Nakada, Vimal Kumar, Yutaka Kameda, Kumiko Kimura, Norihisa Tatarazako, Hiroshi Yamamoto

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Water samples were collected from effluent-dominated urban streams in Tokushima, Kyoto, and Saitama in Japan to roughly determine the contribution of pharmaceuticals and personal care products (PPCPs) and surfactants to whole toxicity of the water. Approximately 100 PPCPs including anionic surfactants such as linear alkylbenzene sulfonate (LAS), were chemically analyzed. Using 14 water samples, chronic or sub-chronic toxicity tests were conducted on three aquatic species, the green alga Raphidocelis subcapitata, the cladoceran Ceriodaphnia dubia, and the zebrafish Danio rerio. Bioassays for the selected individual PPCPs were conducted using the three species. Assuming the concentration addition (CA) model, the contribution of each PPCP to the whole toxicity of the riverwater was estimated based on toxicity unit (TU). The contribution of PPCPs, which primarily consists of a few antibiotic agents such as triclosan and clarithromycin, ranged from 0.9% to 69% of the whole toxicity of the water samples for algae, whereas the selected LAS congeners accounted for at most 5.3%. In contrast, the contribution of LAS ranged from 0.067% to 86% and from 0.021% to 27% of the whole toxicity for cladoceran and zebrafish, respectively, whereas that of PPCPs for these species was at most 2.1% at all sampling points. Our results suggest a limited contribution of PPCPs except for antimicrobial agents and the possible substantial contribution of LAS to toxicity in cladocerans and zebrafish.

Original languageEnglish
Pages (from-to)338-350
Number of pages13
JournalEcotoxicology and Environmental Safety
Volume144
DOIs
Publication statusPublished - Oct 1 2017

Fingerprint

Pharmaceutical Services
Drug products
Toxicity
Effluents
Zebrafish
Water
Algae
Surface-Active Agents
Chronic Toxicity Tests
Triclosan
Antimicrobial agents
Chlorophyta
Clarithromycin
Anionic surfactants
Bioassay
Antibiotics
Anti-Infective Agents
Biological Assay
Japan
Surface active agents

Keywords

  • Anionic surfactant
  • Bioassay
  • PPCPs
  • Whole toxicity

ASJC Scopus subject areas

  • Pollution
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Contribution of pharmaceuticals and personal care products (PPCPs) to whole toxicity of water samples collected in effluent-dominated urban streams. / Tamura, Ikumi; Yasuda, Yusuke; Kagota, Kei ichiro; Yoneda, Saori; Nakada, Norihide; Kumar, Vimal; Kameda, Yutaka; Kimura, Kumiko; Tatarazako, Norihisa; Yamamoto, Hiroshi.

In: Ecotoxicology and Environmental Safety, Vol. 144, 01.10.2017, p. 338-350.

Research output: Contribution to journalArticle

Tamura, Ikumi ; Yasuda, Yusuke ; Kagota, Kei ichiro ; Yoneda, Saori ; Nakada, Norihide ; Kumar, Vimal ; Kameda, Yutaka ; Kimura, Kumiko ; Tatarazako, Norihisa ; Yamamoto, Hiroshi. / Contribution of pharmaceuticals and personal care products (PPCPs) to whole toxicity of water samples collected in effluent-dominated urban streams. In: Ecotoxicology and Environmental Safety. 2017 ; Vol. 144. pp. 338-350.
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AU - Nakada, Norihide

AU - Kumar, Vimal

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AB - Water samples were collected from effluent-dominated urban streams in Tokushima, Kyoto, and Saitama in Japan to roughly determine the contribution of pharmaceuticals and personal care products (PPCPs) and surfactants to whole toxicity of the water. Approximately 100 PPCPs including anionic surfactants such as linear alkylbenzene sulfonate (LAS), were chemically analyzed. Using 14 water samples, chronic or sub-chronic toxicity tests were conducted on three aquatic species, the green alga Raphidocelis subcapitata, the cladoceran Ceriodaphnia dubia, and the zebrafish Danio rerio. Bioassays for the selected individual PPCPs were conducted using the three species. Assuming the concentration addition (CA) model, the contribution of each PPCP to the whole toxicity of the riverwater was estimated based on toxicity unit (TU). The contribution of PPCPs, which primarily consists of a few antibiotic agents such as triclosan and clarithromycin, ranged from 0.9% to 69% of the whole toxicity of the water samples for algae, whereas the selected LAS congeners accounted for at most 5.3%. In contrast, the contribution of LAS ranged from 0.067% to 86% and from 0.021% to 27% of the whole toxicity for cladoceran and zebrafish, respectively, whereas that of PPCPs for these species was at most 2.1% at all sampling points. Our results suggest a limited contribution of PPCPs except for antimicrobial agents and the possible substantial contribution of LAS to toxicity in cladocerans and zebrafish.

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