Contrast-enhanced ultrasonography depicts small tumor vessels for the evaluation of pancreatic tumors

Yuko Okamoto, Hirofumi Kawamoto, Akinobu Takaki, Etsuji Ishida, Tsuneyoshi Ogawa, Kenji Kuwaki, Yoshiyuki Kobayashi, Kohsaku Sakaguchi, Yasushi Shiratori

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14 Citations (Scopus)

Abstract

Objective: The aim of this study is to evaluate the efficacy of contrast-enhanced ultrasonography for the diagnosis of pancreatic tumors. Materials and methods: Contrast-enhanced ultrasonography with Levovist was performed on 62 consecutive patients (53 with pancreatic cancer, 4 with islet cell tumor, 3 with inflammatory pancreatic tumor, and 2 with metastatic tumor). The vascular and perfusion image phases of the tumors were evaluated and compared with the findings of contrast-enhanced computed tomography. Results: Contrast-enhanced ultrasonography showed tumor vessels around and/or in the tumor at the vascular image phase in 79% of pancreatic cancer patients (42/53). At the perfusion image phase, 96% of pancreatic cancers (51/53) were classified as hypo-enhancement type. However, tiny spotty or irregular heterogeneous enhanced lesions were found in 84% of hypo-enhanced pancreatic cancer patients (43/51). The presence of small vessels at the vascular image phase was closely correlated with the presence of these intratumor regional enhanced lesions at the perfusion image phase (κ coefficient = 0.42). The sensitivity of contrast-enhanced ultrasonography (100%) for pancreatic cancer was superior to that of contrast-enhanced computed tomography (91%), but no significant difference was observed between the two (McNemar test: p = 0.063). Conclusion: Contrast-enhanced ultrasonography with Levovist successfully visualizes fine vessels and enhancement in pancreatic tumors, and is useful for evaluating pancreatic tumors.

Original languageEnglish
Pages (from-to)163-169
Number of pages7
JournalEuropean Journal of Radiology
Volume61
Issue number1
DOIs
Publication statusPublished - Jan 2007

Keywords

  • Contrast-enhanced ultrasonography
  • Levovist
  • Pancreatic tumors

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Okamoto, Y., Kawamoto, H., Takaki, A., Ishida, E., Ogawa, T., Kuwaki, K., Kobayashi, Y., Sakaguchi, K., & Shiratori, Y. (2007). Contrast-enhanced ultrasonography depicts small tumor vessels for the evaluation of pancreatic tumors. European Journal of Radiology, 61(1), 163-169. https://doi.org/10.1016/j.ejrad.2006.08.014