Contrast-enhanced CT evaluation of clinically and mammographically occult multiple breast tumors in women with unilateral early breast cancer

Naruto Taira, Shozo Ohsumi, Daisuke Takabatake, Fumikata Hara, Seiki Takashima, Kenjiro Aogi, Shigemitsu Takashima, Takeshi Inoue, Shigenori Sugata, Rieko Nishimura

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Magnetic resonance imaging mammography is performed to determine the extent of lesions and to detect occult lesions, but preoperative diagnosis by breast computed tomography (CT) is less common. Methods: We performed a retrospective study of detection of mammographically occult multiple lesions using breast CT. The subjects were 407 female patients (median age: 56 years old; median tumor size: 1.9 cm) with breast cancer who underwent preoperative, contrast-enhanced breast CT. Results: CT detected 73 incidental-enhanced breast nodules (median size: 0.8 cm) in 73 patients that were undetectable by conventional methods. Age, size of the main lesion or laterality of lesions did not differ between patients with and without incidental nodules, but the frequency of mastectomy was significantly higher in those with incidental nodules. Of the 73 incidental nodules, 22 (30%;) were in the same quadrant as the main lesion, 26 (36%) were in other quadrants and 25 (34%) were in the opposite breast. On qualitative diagnosis by CT, 48 were suspected to be malignant (66%), 17 benign (23%) and eight non-specific (11%). In histological evaluation of 44 of the 48 nodules suspected to be malignant, 24 were malignant (invasive carcinoma: 22, non-invasive carcinoma: 2); of seven of the 17 nodules suspected to be benign, all were benign; and of three of the eight non-specific nodules, one was non-invasive carcinoma. The discovery rate of clinically and mammographically occult multiple lesions by preoperative breast CT was 6%. Conclusion: We conclude that breast CT is useful for the detection of occult lesions and choice of surgical procedure.

Original languageEnglish
Pages (from-to)419-425
Number of pages7
JournalJapanese Journal of Clinical Oncology
Volume38
Issue number6
DOIs
Publication statusPublished - Jun 2008

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Breast
Tomography
Breast Neoplasms
Carcinoma
Mastectomy
Mammography
Unilateral Breast Neoplasms
Retrospective Studies
Magnetic Resonance Imaging
Neoplasms

Keywords

  • Breast CT
  • IEBN
  • Malignancy
  • MRI
  • Occult lesion
  • Preoperative

ASJC Scopus subject areas

  • Oncology

Cite this

Contrast-enhanced CT evaluation of clinically and mammographically occult multiple breast tumors in women with unilateral early breast cancer. / Taira, Naruto; Ohsumi, Shozo; Takabatake, Daisuke; Hara, Fumikata; Takashima, Seiki; Aogi, Kenjiro; Takashima, Shigemitsu; Inoue, Takeshi; Sugata, Shigenori; Nishimura, Rieko.

In: Japanese Journal of Clinical Oncology, Vol. 38, No. 6, 06.2008, p. 419-425.

Research output: Contribution to journalArticle

Taira, N, Ohsumi, S, Takabatake, D, Hara, F, Takashima, S, Aogi, K, Takashima, S, Inoue, T, Sugata, S & Nishimura, R 2008, 'Contrast-enhanced CT evaluation of clinically and mammographically occult multiple breast tumors in women with unilateral early breast cancer', Japanese Journal of Clinical Oncology, vol. 38, no. 6, pp. 419-425. https://doi.org/10.1093/jjco/hyn040
Taira, Naruto ; Ohsumi, Shozo ; Takabatake, Daisuke ; Hara, Fumikata ; Takashima, Seiki ; Aogi, Kenjiro ; Takashima, Shigemitsu ; Inoue, Takeshi ; Sugata, Shigenori ; Nishimura, Rieko. / Contrast-enhanced CT evaluation of clinically and mammographically occult multiple breast tumors in women with unilateral early breast cancer. In: Japanese Journal of Clinical Oncology. 2008 ; Vol. 38, No. 6. pp. 419-425.
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abstract = "Background: Magnetic resonance imaging mammography is performed to determine the extent of lesions and to detect occult lesions, but preoperative diagnosis by breast computed tomography (CT) is less common. Methods: We performed a retrospective study of detection of mammographically occult multiple lesions using breast CT. The subjects were 407 female patients (median age: 56 years old; median tumor size: 1.9 cm) with breast cancer who underwent preoperative, contrast-enhanced breast CT. Results: CT detected 73 incidental-enhanced breast nodules (median size: 0.8 cm) in 73 patients that were undetectable by conventional methods. Age, size of the main lesion or laterality of lesions did not differ between patients with and without incidental nodules, but the frequency of mastectomy was significantly higher in those with incidental nodules. Of the 73 incidental nodules, 22 (30{\%};) were in the same quadrant as the main lesion, 26 (36{\%}) were in other quadrants and 25 (34{\%}) were in the opposite breast. On qualitative diagnosis by CT, 48 were suspected to be malignant (66{\%}), 17 benign (23{\%}) and eight non-specific (11{\%}). In histological evaluation of 44 of the 48 nodules suspected to be malignant, 24 were malignant (invasive carcinoma: 22, non-invasive carcinoma: 2); of seven of the 17 nodules suspected to be benign, all were benign; and of three of the eight non-specific nodules, one was non-invasive carcinoma. The discovery rate of clinically and mammographically occult multiple lesions by preoperative breast CT was 6{\%}. Conclusion: We conclude that breast CT is useful for the detection of occult lesions and choice of surgical procedure.",
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AU - Takashima, Seiki

AU - Aogi, Kenjiro

AU - Takashima, Shigemitsu

AU - Inoue, Takeshi

AU - Sugata, Shigenori

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AB - Background: Magnetic resonance imaging mammography is performed to determine the extent of lesions and to detect occult lesions, but preoperative diagnosis by breast computed tomography (CT) is less common. Methods: We performed a retrospective study of detection of mammographically occult multiple lesions using breast CT. The subjects were 407 female patients (median age: 56 years old; median tumor size: 1.9 cm) with breast cancer who underwent preoperative, contrast-enhanced breast CT. Results: CT detected 73 incidental-enhanced breast nodules (median size: 0.8 cm) in 73 patients that were undetectable by conventional methods. Age, size of the main lesion or laterality of lesions did not differ between patients with and without incidental nodules, but the frequency of mastectomy was significantly higher in those with incidental nodules. Of the 73 incidental nodules, 22 (30%;) were in the same quadrant as the main lesion, 26 (36%) were in other quadrants and 25 (34%) were in the opposite breast. On qualitative diagnosis by CT, 48 were suspected to be malignant (66%), 17 benign (23%) and eight non-specific (11%). In histological evaluation of 44 of the 48 nodules suspected to be malignant, 24 were malignant (invasive carcinoma: 22, non-invasive carcinoma: 2); of seven of the 17 nodules suspected to be benign, all were benign; and of three of the eight non-specific nodules, one was non-invasive carcinoma. The discovery rate of clinically and mammographically occult multiple lesions by preoperative breast CT was 6%. Conclusion: We conclude that breast CT is useful for the detection of occult lesions and choice of surgical procedure.

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