Contrast-enhanced computed tomography screening is efective for detecting venous thromboembolism not prevented by prophylaxis after total knee arthroplasty

Yukimasa Okada, Takayai Furumatsu, Shaichi Miyazawa, Takaaki Tanaka, Masataka Fujii, Toshifumi Ozaki, Nobuhiro Abe

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Venous thromboembolism (VTE) is a potential complication occurring after total knee arthroplasty (TKA). We investigated the incidence of VTE after TKA using contrast-enhanced computed tomography (CT), and assessed the efficacy of VTE prophylaxis (fondaparinux and enoxaparin). At our hospital, 189 patients (225 knees) underwent TKA between April 2007 and October 2011. The 225 knees were divided into a control group with no VTE prophylaxis (31 cases), a fondaparinux group (107 cases), and an enoxaparin group (87 cases). Contrast-enhanced CT screening for VTE was performed in all cases on day 5 or 6 after TKA. D-dimer levels were measured on day 5 after TKA, and were significantly lower in the fondaparinux (9.8 ± 3.8) and enoxaparin groups (9.4 ± 4.9) than in the control group (15.6 ± 9.8) (p < 0.001). However, no statistically significant difference in the incidence of VTE was observed among the groups (control, 61.3%; fondaparinux, 49.5%; enoxaparin, 50.6%). Prophylaxis was not effective for the prevention of VTE as detected by contrast-enhanced CT after TKA. CT should be performed after TKA, even when VTE prophylaxis is used.

Original languageEnglish
Pages (from-to)355-360
Number of pages6
JournalActa medica Okayama
Volume69
Issue number6
Publication statusPublished - 2015

Keywords

  • Contrast-enhanced computed tomography
  • Enoxaparin
  • Fondaparinux
  • Total knee arthroplasty
  • Venous thromboembolism

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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