Contrast echocardiographic assessments of myocardial blood flow in acute myocardial infarction

Hiroshi Itoh, T. Tomooka, N. Akehi, N. Sakai, Y. Higashino, K. Fujii, O. Kato, T. Minamino

Research output: Contribution to journalArticle

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Abstract

Clinical information on the regional myocardial blood flow in the post-ischemic myocardium has been limited. In the present study, we assessed the influence of early coronary reperfusion and coronary obstruction that remained after reperfusion on regional myocardial perfusion by myocardial contrast echocardiography. The study population consisted of 17 patients with acute myocardial infarction who underwent either successful PTCR or emergent PTCA within 6 hours after the onset of the symptom. Myocardial blood flow was visualized by selective injections of hand-agitated polygelin colloid solutions into the right and left coronary arteries before and after coronary reperfusion. Before coronary reperfusion, the area at risk for necrosis was defined as the area of contrast defects by the intracoronary injection of contrast medium. The size (severity) of this defect correlated with the anatomic distribution of the obstructed coronary artery. Immediately after emergent PTCA (mean residual stenosis=25%), 2 of 10 patients still showed injected contrast medium, however, in the remaining 8 patients (80%), the contrast washout time in the risk area was 1.5 times (mean value) longer than that in the normal region. This indicated impairment of the microcirculation in the postischemic myocardium. Immediately PTCR (mean residual stenosis =89%, p

Original languageEnglish
Pages (from-to)631-639
Number of pages9
JournalJournal of Cardiology
Volume21
Issue number3
Publication statusPublished - 1991
Externally publishedYes

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Myocardial Reperfusion
Myocardial Infarction
Contrast Media
Coronary Vessels
Myocardium
Pathologic Constriction
Injections
Regional Blood Flow
Colloids
Microcirculation
Reperfusion
Echocardiography
Necrosis
Hand
Perfusion
Population

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Itoh, H., Tomooka, T., Akehi, N., Sakai, N., Higashino, Y., Fujii, K., ... Minamino, T. (1991). Contrast echocardiographic assessments of myocardial blood flow in acute myocardial infarction. Journal of Cardiology, 21(3), 631-639.

Contrast echocardiographic assessments of myocardial blood flow in acute myocardial infarction. / Itoh, Hiroshi; Tomooka, T.; Akehi, N.; Sakai, N.; Higashino, Y.; Fujii, K.; Kato, O.; Minamino, T.

In: Journal of Cardiology, Vol. 21, No. 3, 1991, p. 631-639.

Research output: Contribution to journalArticle

Itoh, H, Tomooka, T, Akehi, N, Sakai, N, Higashino, Y, Fujii, K, Kato, O & Minamino, T 1991, 'Contrast echocardiographic assessments of myocardial blood flow in acute myocardial infarction', Journal of Cardiology, vol. 21, no. 3, pp. 631-639.
Itoh H, Tomooka T, Akehi N, Sakai N, Higashino Y, Fujii K et al. Contrast echocardiographic assessments of myocardial blood flow in acute myocardial infarction. Journal of Cardiology. 1991;21(3):631-639.
Itoh, Hiroshi ; Tomooka, T. ; Akehi, N. ; Sakai, N. ; Higashino, Y. ; Fujii, K. ; Kato, O. ; Minamino, T. / Contrast echocardiographic assessments of myocardial blood flow in acute myocardial infarction. In: Journal of Cardiology. 1991 ; Vol. 21, No. 3. pp. 631-639.
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