Continuous synthesis of glyceryl ferulate using immobilized Candida antarctica lipase

Takemasa Matsuo, Takashi Kobayashi, Yukitaka Kimura, Asao Hosoda, Hisaji Taniguchi, Shuji Adachi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Glyceryl ferulate was synthesized through condensation of ferulic acid and glycerol at 50°C in glycerols with different water contents using an immobilized lipase from Candida antarctica in a batch reactor, and condensation in the glycerol with a 7.5% (w/w) water content was shown to be the favorite. The solubility of ferulic acid was higher at higher temperature in glycerol with a lower water content. The viscosity was lower at higher temperature for the glycerol with a higher water content. The condensation was carried out using a batch reactor at a temperature from 50°C to 90°C. These observations indicated that the condensation at 80°C in the glycerol with a 7.5% (w/w) water content was the most adequate for continuously synthesizing glyceryl ferulate. A reactor system was constructed for the continuous synthesis and was steadily operated to realize a productivity of 430 kg/(m3-reactor(day) without any decrease in the conversion for at least 6 days.

Original languageEnglish
Pages (from-to)375-380
Number of pages6
JournalJournal of Oleo Science
Volume57
Issue number7
Publication statusPublished - 2008
Externally publishedYes

Fingerprint

Candida
Lipases
Lipase
Glycerol
ferulic acid
Water content
Condensation
Batch reactors
Acids
Temperature
glyceryl ferulate
Solubility
Productivity
Viscosity

Keywords

  • CALB
  • Candida antarctica lipase
  • Condensation
  • Ferulic acid
  • Glyceryl ferulate

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Chemistry(all)

Cite this

Matsuo, T., Kobayashi, T., Kimura, Y., Hosoda, A., Taniguchi, H., & Adachi, S. (2008). Continuous synthesis of glyceryl ferulate using immobilized Candida antarctica lipase. Journal of Oleo Science, 57(7), 375-380.

Continuous synthesis of glyceryl ferulate using immobilized Candida antarctica lipase. / Matsuo, Takemasa; Kobayashi, Takashi; Kimura, Yukitaka; Hosoda, Asao; Taniguchi, Hisaji; Adachi, Shuji.

In: Journal of Oleo Science, Vol. 57, No. 7, 2008, p. 375-380.

Research output: Contribution to journalArticle

Matsuo, T, Kobayashi, T, Kimura, Y, Hosoda, A, Taniguchi, H & Adachi, S 2008, 'Continuous synthesis of glyceryl ferulate using immobilized Candida antarctica lipase', Journal of Oleo Science, vol. 57, no. 7, pp. 375-380.
Matsuo T, Kobayashi T, Kimura Y, Hosoda A, Taniguchi H, Adachi S. Continuous synthesis of glyceryl ferulate using immobilized Candida antarctica lipase. Journal of Oleo Science. 2008;57(7):375-380.
Matsuo, Takemasa ; Kobayashi, Takashi ; Kimura, Yukitaka ; Hosoda, Asao ; Taniguchi, Hisaji ; Adachi, Shuji. / Continuous synthesis of glyceryl ferulate using immobilized Candida antarctica lipase. In: Journal of Oleo Science. 2008 ; Vol. 57, No. 7. pp. 375-380.
@article{59164b3911cf4e30b62e4bb1f9f346b5,
title = "Continuous synthesis of glyceryl ferulate using immobilized Candida antarctica lipase",
abstract = "Glyceryl ferulate was synthesized through condensation of ferulic acid and glycerol at 50°C in glycerols with different water contents using an immobilized lipase from Candida antarctica in a batch reactor, and condensation in the glycerol with a 7.5{\%} (w/w) water content was shown to be the favorite. The solubility of ferulic acid was higher at higher temperature in glycerol with a lower water content. The viscosity was lower at higher temperature for the glycerol with a higher water content. The condensation was carried out using a batch reactor at a temperature from 50°C to 90°C. These observations indicated that the condensation at 80°C in the glycerol with a 7.5{\%} (w/w) water content was the most adequate for continuously synthesizing glyceryl ferulate. A reactor system was constructed for the continuous synthesis and was steadily operated to realize a productivity of 430 kg/(m3-reactor(day) without any decrease in the conversion for at least 6 days.",
keywords = "CALB, Candida antarctica lipase, Condensation, Ferulic acid, Glyceryl ferulate",
author = "Takemasa Matsuo and Takashi Kobayashi and Yukitaka Kimura and Asao Hosoda and Hisaji Taniguchi and Shuji Adachi",
year = "2008",
language = "English",
volume = "57",
pages = "375--380",
journal = "Journal of Oleo Science",
issn = "1345-8957",
publisher = "Japan Oil Chemists Society",
number = "7",

}

TY - JOUR

T1 - Continuous synthesis of glyceryl ferulate using immobilized Candida antarctica lipase

AU - Matsuo, Takemasa

AU - Kobayashi, Takashi

AU - Kimura, Yukitaka

AU - Hosoda, Asao

AU - Taniguchi, Hisaji

AU - Adachi, Shuji

PY - 2008

Y1 - 2008

N2 - Glyceryl ferulate was synthesized through condensation of ferulic acid and glycerol at 50°C in glycerols with different water contents using an immobilized lipase from Candida antarctica in a batch reactor, and condensation in the glycerol with a 7.5% (w/w) water content was shown to be the favorite. The solubility of ferulic acid was higher at higher temperature in glycerol with a lower water content. The viscosity was lower at higher temperature for the glycerol with a higher water content. The condensation was carried out using a batch reactor at a temperature from 50°C to 90°C. These observations indicated that the condensation at 80°C in the glycerol with a 7.5% (w/w) water content was the most adequate for continuously synthesizing glyceryl ferulate. A reactor system was constructed for the continuous synthesis and was steadily operated to realize a productivity of 430 kg/(m3-reactor(day) without any decrease in the conversion for at least 6 days.

AB - Glyceryl ferulate was synthesized through condensation of ferulic acid and glycerol at 50°C in glycerols with different water contents using an immobilized lipase from Candida antarctica in a batch reactor, and condensation in the glycerol with a 7.5% (w/w) water content was shown to be the favorite. The solubility of ferulic acid was higher at higher temperature in glycerol with a lower water content. The viscosity was lower at higher temperature for the glycerol with a higher water content. The condensation was carried out using a batch reactor at a temperature from 50°C to 90°C. These observations indicated that the condensation at 80°C in the glycerol with a 7.5% (w/w) water content was the most adequate for continuously synthesizing glyceryl ferulate. A reactor system was constructed for the continuous synthesis and was steadily operated to realize a productivity of 430 kg/(m3-reactor(day) without any decrease in the conversion for at least 6 days.

KW - CALB

KW - Candida antarctica lipase

KW - Condensation

KW - Ferulic acid

KW - Glyceryl ferulate

UR - http://www.scopus.com/inward/record.url?scp=45749115459&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=45749115459&partnerID=8YFLogxK

M3 - Article

C2 - 18536506

AN - SCOPUS:45749115459

VL - 57

SP - 375

EP - 380

JO - Journal of Oleo Science

JF - Journal of Oleo Science

SN - 1345-8957

IS - 7

ER -