Continuous fabrication of monodisperse polylactide microspheres by droplet-to-particle technology using microfluidic emulsification and emulsion-solvent diffusion

Takaichi Watanabe; Tsutomu Ono; Yukitaka Kimura

doi:10.1039/c1sm05910f

Continuous fabrication of monodisperse polylactide microspheres by droplet-to-particle technology using microfluidic emulsification and emulsion-solvent diffusion

Takaichi Watanabe, Tsutomu Ono, Yukitaka Kimura

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

Monodisperse polylactide (PLA) microspheres were continuously fabricated by microfluidic emulsification and subsequent dilution in water. The diameter was precisely tuned from 6 to 50 μm by changing the flow rate of the fluids in microfluidics or the PLA concentration in the dispersed phase. The use of amphiphilic oil-soluble poly(ethylene glycol)-b-polylactide (o-PEG-PLA) as a matrix resulted in a highly porous microsphere morphology, and the porosity was controlled by blending PLA. Therefore, monodisperse PLA microspheres with the predetermined surface porosity were continuously produced by just enough reagents and energy.

Original language	English
Pages (from-to)	9894-9897
Number of pages	4
Journal	Soft Matter
Volume	7
Issue number	21
DOIs	https://doi.org/10.1039/c1sm05910f
Publication status	Published - Nov 7 2011

ASJC Scopus subject areas

Chemistry(all)
Condensed Matter Physics

Access to Document

10.1039/c1sm05910f

Cite this

@article{85ad066d42ed44d6ad5e2bf0483075c8,

title = "Continuous fabrication of monodisperse polylactide microspheres by droplet-to-particle technology using microfluidic emulsification and emulsion-solvent diffusion",

abstract = "Monodisperse polylactide (PLA) microspheres were continuously fabricated by microfluidic emulsification and subsequent dilution in water. The diameter was precisely tuned from 6 to 50 μm by changing the flow rate of the fluids in microfluidics or the PLA concentration in the dispersed phase. The use of amphiphilic oil-soluble poly(ethylene glycol)-b-polylactide (o-PEG-PLA) as a matrix resulted in a highly porous microsphere morphology, and the porosity was controlled by blending PLA. Therefore, monodisperse PLA microspheres with the predetermined surface porosity were continuously produced by just enough reagents and energy.",

author = "Takaichi Watanabe and Tsutomu Ono and Yukitaka Kimura",

year = "2011",

month = nov,

day = "7",

doi = "10.1039/c1sm05910f",

language = "English",

volume = "7",

pages = "9894--9897",

journal = "Soft Matter",

issn = "1744-683X",

publisher = "Royal Society of Chemistry",

number = "21",

}

TY - JOUR

T1 - Continuous fabrication of monodisperse polylactide microspheres by droplet-to-particle technology using microfluidic emulsification and emulsion-solvent diffusion

AU - Watanabe, Takaichi

AU - Ono, Tsutomu

AU - Kimura, Yukitaka

PY - 2011/11/7

Y1 - 2011/11/7

N2 - Monodisperse polylactide (PLA) microspheres were continuously fabricated by microfluidic emulsification and subsequent dilution in water. The diameter was precisely tuned from 6 to 50 μm by changing the flow rate of the fluids in microfluidics or the PLA concentration in the dispersed phase. The use of amphiphilic oil-soluble poly(ethylene glycol)-b-polylactide (o-PEG-PLA) as a matrix resulted in a highly porous microsphere morphology, and the porosity was controlled by blending PLA. Therefore, monodisperse PLA microspheres with the predetermined surface porosity were continuously produced by just enough reagents and energy.

AB - Monodisperse polylactide (PLA) microspheres were continuously fabricated by microfluidic emulsification and subsequent dilution in water. The diameter was precisely tuned from 6 to 50 μm by changing the flow rate of the fluids in microfluidics or the PLA concentration in the dispersed phase. The use of amphiphilic oil-soluble poly(ethylene glycol)-b-polylactide (o-PEG-PLA) as a matrix resulted in a highly porous microsphere morphology, and the porosity was controlled by blending PLA. Therefore, monodisperse PLA microspheres with the predetermined surface porosity were continuously produced by just enough reagents and energy.

UR - http://www.scopus.com/inward/record.url?scp=80054986767&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80054986767&partnerID=8YFLogxK

U2 - 10.1039/c1sm05910f

DO - 10.1039/c1sm05910f

M3 - Article

AN - SCOPUS:80054986767

VL - 7

SP - 9894

EP - 9897

JO - Soft Matter

JF - Soft Matter

SN - 1744-683X

IS - 21

ER -

Continuous fabrication of monodisperse polylactide microspheres by droplet-to-particle technology using microfluidic emulsification and emulsion-solvent diffusion

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this