Abstract
Monodisperse polylactide (PLA) microspheres were continuously fabricated by microfluidic emulsification and subsequent dilution in water. The diameter was precisely tuned from 6 to 50 μm by changing the flow rate of the fluids in microfluidics or the PLA concentration in the dispersed phase. The use of amphiphilic oil-soluble poly(ethylene glycol)-b-polylactide (o-PEG-PLA) as a matrix resulted in a highly porous microsphere morphology, and the porosity was controlled by blending PLA. Therefore, monodisperse PLA microspheres with the predetermined surface porosity were continuously produced by just enough reagents and energy.
| Original language | English |
|---|---|
| Pages (from-to) | 9894-9897 |
| Number of pages | 4 |
| Journal | Soft Matter |
| Volume | 7 |
| Issue number | 21 |
| DOIs | |
| Publication status | Published - Nov 7 2011 |
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ASJC Scopus subject areas
- Chemistry(all)
- Condensed Matter Physics
Cite this
Continuous fabrication of monodisperse polylactide microspheres by droplet-to-particle technology using microfluidic emulsification and emulsion-solvent diffusion. / Watanabe, Takaichi; Ono, Tsutomu; Kimura, Yukitaka.
In: Soft Matter, Vol. 7, No. 21, 07.11.2011, p. 9894-9897.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Continuous fabrication of monodisperse polylactide microspheres by droplet-to-particle technology using microfluidic emulsification and emulsion-solvent diffusion
AU - Watanabe, Takaichi
AU - Ono, Tsutomu
AU - Kimura, Yukitaka
PY - 2011/11/7
Y1 - 2011/11/7
N2 - Monodisperse polylactide (PLA) microspheres were continuously fabricated by microfluidic emulsification and subsequent dilution in water. The diameter was precisely tuned from 6 to 50 μm by changing the flow rate of the fluids in microfluidics or the PLA concentration in the dispersed phase. The use of amphiphilic oil-soluble poly(ethylene glycol)-b-polylactide (o-PEG-PLA) as a matrix resulted in a highly porous microsphere morphology, and the porosity was controlled by blending PLA. Therefore, monodisperse PLA microspheres with the predetermined surface porosity were continuously produced by just enough reagents and energy.
AB - Monodisperse polylactide (PLA) microspheres were continuously fabricated by microfluidic emulsification and subsequent dilution in water. The diameter was precisely tuned from 6 to 50 μm by changing the flow rate of the fluids in microfluidics or the PLA concentration in the dispersed phase. The use of amphiphilic oil-soluble poly(ethylene glycol)-b-polylactide (o-PEG-PLA) as a matrix resulted in a highly porous microsphere morphology, and the porosity was controlled by blending PLA. Therefore, monodisperse PLA microspheres with the predetermined surface porosity were continuously produced by just enough reagents and energy.
UR - http://www.scopus.com/inward/record.url?scp=80054986767&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80054986767&partnerID=8YFLogxK
U2 - 10.1039/c1sm05910f
DO - 10.1039/c1sm05910f
M3 - Article
AN - SCOPUS:80054986767
VL - 7
SP - 9894
EP - 9897
JO - Soft Matter
JF - Soft Matter
SN - 1744-683X
IS - 21
ER -