Continuous fabrication of monodisperse polylactide microspheres by droplet-to-particle technology using microfluidic emulsification and emulsion-solvent diffusion

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Abstract

Monodisperse polylactide (PLA) microspheres were continuously fabricated by microfluidic emulsification and subsequent dilution in water. The diameter was precisely tuned from 6 to 50 μm by changing the flow rate of the fluids in microfluidics or the PLA concentration in the dispersed phase. The use of amphiphilic oil-soluble poly(ethylene glycol)-b-polylactide (o-PEG-PLA) as a matrix resulted in a highly porous microsphere morphology, and the porosity was controlled by blending PLA. Therefore, monodisperse PLA microspheres with the predetermined surface porosity were continuously produced by just enough reagents and energy.

Original languageEnglish
Pages (from-to)9894-9897
Number of pages4
JournalSoft Matter
Volume7
Issue number21
DOIs
Publication statusPublished - Nov 7 2011

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Emulsification
Emulsions
Microspheres
Microfluidics
emulsions
porosity
Fabrication
fabrication
reagents
dilution
glycols
ethylene
flow velocity
oils
Porosity
fluids
matrices
water
Polyethylene glycols
Dilution

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics

Cite this

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AB - Monodisperse polylactide (PLA) microspheres were continuously fabricated by microfluidic emulsification and subsequent dilution in water. The diameter was precisely tuned from 6 to 50 μm by changing the flow rate of the fluids in microfluidics or the PLA concentration in the dispersed phase. The use of amphiphilic oil-soluble poly(ethylene glycol)-b-polylactide (o-PEG-PLA) as a matrix resulted in a highly porous microsphere morphology, and the porosity was controlled by blending PLA. Therefore, monodisperse PLA microspheres with the predetermined surface porosity were continuously produced by just enough reagents and energy.

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