Continuous fabrication of monodisperse polylactide microspheres by droplet-to-particle technology using microfluidic emulsification and emulsion-solvent diffusion

Takaichi Watanabe; Tsutomu Ono; Yukitaka Kimura

doi:10.1039/c1sm05910f

Continuous fabrication of monodisperse polylactide microspheres by droplet-to-particle technology using microfluidic emulsification and emulsion-solvent diffusion

Takaichi Watanabe, Tsutomu Ono, Yukitaka Kimura

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

Monodisperse polylactide (PLA) microspheres were continuously fabricated by microfluidic emulsification and subsequent dilution in water. The diameter was precisely tuned from 6 to 50 μm by changing the flow rate of the fluids in microfluidics or the PLA concentration in the dispersed phase. The use of amphiphilic oil-soluble poly(ethylene glycol)-b-polylactide (o-PEG-PLA) as a matrix resulted in a highly porous microsphere morphology, and the porosity was controlled by blending PLA. Therefore, monodisperse PLA microspheres with the predetermined surface porosity were continuously produced by just enough reagents and energy.

Original language	English
Pages (from-to)	9894-9897
Number of pages	4
Journal	Soft Matter
Volume	7
Issue number	21
DOIs	https://doi.org/10.1039/c1sm05910f
Publication status	Published - Nov 7 2011

ASJC Scopus subject areas

Chemistry(all)
Condensed Matter Physics

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Continuous fabrication of monodisperse polylactide microspheres by droplet-to-particle technology using microfluidic emulsification and emulsion-solvent diffusion

Abstract

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