Construction of cephem framework via sequential reductive 1,2-elimination-hydride addition in a tributyltin hydride-copper(I) chloride-NMP system: Synthesis of 3-norcephalosporin

Hideo Tanaka; Yoshihiko Yamaguchi; Shin Ichi Sumida; Sigeru Torii

doi:10.1039/CC9960002705

Construction of cephem framework via sequential reductive 1,2-elimination-hydride addition in a tributyltin hydride-copper(I) chloride-NMP system: Synthesis of 3-norcephalosporin

Hideo Tanaka, Yoshihiko Yamaguchi, Shin Ichi Sumida, Sigeru Torii

Faculty of Engineering

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

A sequential reductive 1,2-elimination and hydride addition process for 3,4-disubstituted butenoates derived from penicillin is successfully performed with the aid of a combination of tributyltin hydride and copper(I) chloride in N-methyl-2-pyrrolidinone (NMP) to afford 3-norcephalosporin.

Original language	English
Pages (from-to)	2705-2706
Number of pages	2
Journal	Chemical Communications
Issue number	24
DOIs	https://doi.org/10.1039/CC9960002705
Publication status	Published - Jan 1 1996

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/CC9960002705

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Construction of cephem framework via sequential reductive 1,2-elimination-hydride addition in a tributyltin hydride-copper(I) chloride-NMP system : Synthesis of 3-norcephalosporin. / Tanaka, Hideo; Yamaguchi, Yoshihiko; Sumida, Shin Ichi; Torii, Sigeru.

In: Chemical Communications, No. 24, 01.01.1996, p. 2705-2706.

Research output: Contribution to journal › Article › peer-review

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AB - A sequential reductive 1,2-elimination and hydride addition process for 3,4-disubstituted butenoates derived from penicillin is successfully performed with the aid of a combination of tributyltin hydride and copper(I) chloride in N-methyl-2-pyrrolidinone (NMP) to afford 3-norcephalosporin.

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Construction of cephem framework via sequential reductive 1,2-elimination-hydride addition in a tributyltin hydride-copper(I) chloride-NMP system: Synthesis of 3-norcephalosporin

Abstract

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