Conserved fungal LysM effector Ecp6 prevents chitin-triggered immunity in plants

Ronnie De Jonge, H. Peter Van Esse, Anja Kombrink, Tomonori Shinya, Yoshitake Desaki, Ralph Bours, Sander Van Der Krol, Naoto Shibuya, Matthieu H A J Joosten, Bart P H J Thomma

Research output: Contribution to journalArticle

346 Citations (Scopus)

Abstract

Multicellular organisms activate immunity upon recognition of pathogen-associated molecular patterns (PAMPs). Chitin is the major component of fungal cell walls, and chitin oligosaccharides act as PAMPs in plant and mammalian cells. Microbial pathogens deliver effector proteins to suppress PAMP-triggered host immunity and to establish infection. Here, we show that the LysM domain-containing effector protein Ecp6 of the fungal plant pathogen Cladosporium fulvum mediates virulence through perturbation of chitin-triggered host immunity. During infection, Ecp6 sequesters chitin oligosaccharides that are released from the cell walls of invading hyphae to prevent elicitation of host immunity. This may represent a common strategy of host immune suppression by fungal pathogens, because LysM effectors are widely conserved in the fungal kingdom.

Original languageEnglish
Pages (from-to)953-955
Number of pages3
JournalScience
Volume329
Issue number5994
DOIs
Publication statusPublished - Aug 20 2010
Externally publishedYes

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Plant Immunity
Chitin
Immunity
Oligosaccharides
Cell Wall
Fungal Structures
Cladosporium
Fungal Proteins
Hyphae
Plant Cells
Infection
Virulence
Pathogen-Associated Molecular Pattern Molecules
Proteins

ASJC Scopus subject areas

  • General

Cite this

De Jonge, R., Van Esse, H. P., Kombrink, A., Shinya, T., Desaki, Y., Bours, R., ... Thomma, B. P. H. J. (2010). Conserved fungal LysM effector Ecp6 prevents chitin-triggered immunity in plants. Science, 329(5994), 953-955. https://doi.org/10.1126/science.1190859

Conserved fungal LysM effector Ecp6 prevents chitin-triggered immunity in plants. / De Jonge, Ronnie; Van Esse, H. Peter; Kombrink, Anja; Shinya, Tomonori; Desaki, Yoshitake; Bours, Ralph; Van Der Krol, Sander; Shibuya, Naoto; Joosten, Matthieu H A J; Thomma, Bart P H J.

In: Science, Vol. 329, No. 5994, 20.08.2010, p. 953-955.

Research output: Contribution to journalArticle

De Jonge, R, Van Esse, HP, Kombrink, A, Shinya, T, Desaki, Y, Bours, R, Van Der Krol, S, Shibuya, N, Joosten, MHAJ & Thomma, BPHJ 2010, 'Conserved fungal LysM effector Ecp6 prevents chitin-triggered immunity in plants', Science, vol. 329, no. 5994, pp. 953-955. https://doi.org/10.1126/science.1190859
De Jonge R, Van Esse HP, Kombrink A, Shinya T, Desaki Y, Bours R et al. Conserved fungal LysM effector Ecp6 prevents chitin-triggered immunity in plants. Science. 2010 Aug 20;329(5994):953-955. https://doi.org/10.1126/science.1190859
De Jonge, Ronnie ; Van Esse, H. Peter ; Kombrink, Anja ; Shinya, Tomonori ; Desaki, Yoshitake ; Bours, Ralph ; Van Der Krol, Sander ; Shibuya, Naoto ; Joosten, Matthieu H A J ; Thomma, Bart P H J. / Conserved fungal LysM effector Ecp6 prevents chitin-triggered immunity in plants. In: Science. 2010 ; Vol. 329, No. 5994. pp. 953-955.
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