Abstract
Understanding dendritic cell (DC) subset functions should lead to the development of novel types of vaccine. Here we characterized expression of XC chemokine receptor 1 (XCR1) and its ligand, XCL1. Murine XCR1 was the only chemokine receptor selectively expressed in CD8α+ conventional DCs. XCL1 was constitutively expressed in NK cells, which contribute to serum XCL1 levels. NK and CD8+ T cells increased XCL1 production upon activation. These expression patterns were conserved in human blood cells, including the BDCA3+ DC subset. Thus, in human and mice, certain DC subsets should be chemotactic towards NK or activated CD8+ T cells through XCR1.
| Original language | English |
|---|---|
| Pages (from-to) | 756-761 |
| Number of pages | 6 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 397 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jul 2010 |
| Externally published | Yes |
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Keywords
- Chemokine
- Dendritic cells
- XCL1
- XCR1
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Cell Biology
- Molecular Biology
Cite this
Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice. / Yamazaki, Chihiro; Miyamoto, Rie; Hoshino, Katsuaki; Fukuda, Yuri; Sasaki, Izumi; Saito, Masuyoshi; Ishiguchi, Hironori; Yano, Takahiro; Sugiyama, Takahiro; Hemmi, Hiroaki; Tanaka, Takashi; Hamada, Eri; Hirashima, Takeshi; Amakawa, Ryuichi; Fukuhara, Shirou; Nomura, Shosaku; Ito, Tomoki; Kaisho, Tsuneyasu.
In: Biochemical and Biophysical Research Communications, Vol. 397, No. 4, 07.2010, p. 756-761.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice
AU - Yamazaki, Chihiro
AU - Miyamoto, Rie
AU - Hoshino, Katsuaki
AU - Fukuda, Yuri
AU - Sasaki, Izumi
AU - Saito, Masuyoshi
AU - Ishiguchi, Hironori
AU - Yano, Takahiro
AU - Sugiyama, Takahiro
AU - Hemmi, Hiroaki
AU - Tanaka, Takashi
AU - Hamada, Eri
AU - Hirashima, Takeshi
AU - Amakawa, Ryuichi
AU - Fukuhara, Shirou
AU - Nomura, Shosaku
AU - Ito, Tomoki
AU - Kaisho, Tsuneyasu
PY - 2010/7
Y1 - 2010/7
N2 - Understanding dendritic cell (DC) subset functions should lead to the development of novel types of vaccine. Here we characterized expression of XC chemokine receptor 1 (XCR1) and its ligand, XCL1. Murine XCR1 was the only chemokine receptor selectively expressed in CD8α+ conventional DCs. XCL1 was constitutively expressed in NK cells, which contribute to serum XCL1 levels. NK and CD8+ T cells increased XCL1 production upon activation. These expression patterns were conserved in human blood cells, including the BDCA3+ DC subset. Thus, in human and mice, certain DC subsets should be chemotactic towards NK or activated CD8+ T cells through XCR1.
AB - Understanding dendritic cell (DC) subset functions should lead to the development of novel types of vaccine. Here we characterized expression of XC chemokine receptor 1 (XCR1) and its ligand, XCL1. Murine XCR1 was the only chemokine receptor selectively expressed in CD8α+ conventional DCs. XCL1 was constitutively expressed in NK cells, which contribute to serum XCL1 levels. NK and CD8+ T cells increased XCL1 production upon activation. These expression patterns were conserved in human blood cells, including the BDCA3+ DC subset. Thus, in human and mice, certain DC subsets should be chemotactic towards NK or activated CD8+ T cells through XCR1.
KW - Chemokine
KW - Dendritic cells
KW - XCL1
KW - XCR1
UR - http://www.scopus.com/inward/record.url?scp=77954384422&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77954384422&partnerID=8YFLogxK
U2 - 10.1016/j.bbrc.2010.06.029
DO - 10.1016/j.bbrc.2010.06.029
M3 - Article
C2 - 20541533
AN - SCOPUS:77954384422
VL - 397
SP - 756
EP - 761
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 4
ER -