Abstract
Understanding dendritic cell (DC) subset functions should lead to the development of novel types of vaccine. Here we characterized expression of XC chemokine receptor 1 (XCR1) and its ligand, XCL1. Murine XCR1 was the only chemokine receptor selectively expressed in CD8α+ conventional DCs. XCL1 was constitutively expressed in NK cells, which contribute to serum XCL1 levels. NK and CD8+ T cells increased XCL1 production upon activation. These expression patterns were conserved in human blood cells, including the BDCA3+ DC subset. Thus, in human and mice, certain DC subsets should be chemotactic towards NK or activated CD8+ T cells through XCR1.
Original language | English |
---|---|
Pages (from-to) | 756-761 |
Number of pages | 6 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 397 |
Issue number | 4 |
DOIs | |
Publication status | Published - Jul 2010 |
Externally published | Yes |
Keywords
- Chemokine
- Dendritic cells
- XCL1
- XCR1
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology