Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice

Chihiro Yamazaki, Rie Miyamoto, Katsuaki Hoshino, Yuri Fukuda, Izumi Sasaki, Masuyoshi Saito, Hironori Ishiguchi, Takahiro Yano, Takahiro Sugiyama, Hiroaki Hemmi, Takashi Tanaka, Eri Hamada, Takeshi Hirashima, Ryuichi Amakawa, Shirou Fukuhara, Shosaku Nomura, Tomoki Ito, Tsuneyasu Kaisho

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Understanding dendritic cell (DC) subset functions should lead to the development of novel types of vaccine. Here we characterized expression of XC chemokine receptor 1 (XCR1) and its ligand, XCL1. Murine XCR1 was the only chemokine receptor selectively expressed in CD8α+ conventional DCs. XCL1 was constitutively expressed in NK cells, which contribute to serum XCL1 levels. NK and CD8+ T cells increased XCL1 production upon activation. These expression patterns were conserved in human blood cells, including the BDCA3+ DC subset. Thus, in human and mice, certain DC subsets should be chemotactic towards NK or activated CD8+ T cells through XCR1.

Original languageEnglish
Pages (from-to)756-761
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume397
Issue number4
DOIs
Publication statusPublished - Jul 2010
Externally publishedYes

Fingerprint

Chemokine Receptors
Chemokines
Conservation
Dendritic Cells
Ligands
T-cells
T-Lymphocytes
Set theory
Natural Killer Cells
Blood Cells
Blood
Vaccines
Chemical activation
Cells
Serum

Keywords

  • Chemokine
  • Dendritic cells
  • XCL1
  • XCR1

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

Cite this

Yamazaki, C., Miyamoto, R., Hoshino, K., Fukuda, Y., Sasaki, I., Saito, M., ... Kaisho, T. (2010). Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice. Biochemical and Biophysical Research Communications, 397(4), 756-761. https://doi.org/10.1016/j.bbrc.2010.06.029

Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice. / Yamazaki, Chihiro; Miyamoto, Rie; Hoshino, Katsuaki; Fukuda, Yuri; Sasaki, Izumi; Saito, Masuyoshi; Ishiguchi, Hironori; Yano, Takahiro; Sugiyama, Takahiro; Hemmi, Hiroaki; Tanaka, Takashi; Hamada, Eri; Hirashima, Takeshi; Amakawa, Ryuichi; Fukuhara, Shirou; Nomura, Shosaku; Ito, Tomoki; Kaisho, Tsuneyasu.

In: Biochemical and Biophysical Research Communications, Vol. 397, No. 4, 07.2010, p. 756-761.

Research output: Contribution to journalArticle

Yamazaki, C, Miyamoto, R, Hoshino, K, Fukuda, Y, Sasaki, I, Saito, M, Ishiguchi, H, Yano, T, Sugiyama, T, Hemmi, H, Tanaka, T, Hamada, E, Hirashima, T, Amakawa, R, Fukuhara, S, Nomura, S, Ito, T & Kaisho, T 2010, 'Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice', Biochemical and Biophysical Research Communications, vol. 397, no. 4, pp. 756-761. https://doi.org/10.1016/j.bbrc.2010.06.029
Yamazaki, Chihiro ; Miyamoto, Rie ; Hoshino, Katsuaki ; Fukuda, Yuri ; Sasaki, Izumi ; Saito, Masuyoshi ; Ishiguchi, Hironori ; Yano, Takahiro ; Sugiyama, Takahiro ; Hemmi, Hiroaki ; Tanaka, Takashi ; Hamada, Eri ; Hirashima, Takeshi ; Amakawa, Ryuichi ; Fukuhara, Shirou ; Nomura, Shosaku ; Ito, Tomoki ; Kaisho, Tsuneyasu. / Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice. In: Biochemical and Biophysical Research Communications. 2010 ; Vol. 397, No. 4. pp. 756-761.
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