Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice

Chihiro Yamazaki; Rie Miyamoto; Katsuaki Hoshino; Yuri Fukuda; Izumi Sasaki; Masuyoshi Saito; Hironori Ishiguchi; Takahiro Yano; Takahiro Sugiyama; Hiroaki Hemmi; Takashi Tanaka; Eri Hamada; Takeshi Hirashima; Ryuichi Amakawa; Shirou Fukuhara; Shosaku Nomura; Tomoki Ito; Tsuneyasu Kaisho

doi:10.1016/j.bbrc.2010.06.029

Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice

Chihiro Yamazaki, Rie Miyamoto, Katsuaki Hoshino, Yuri Fukuda, Izumi Sasaki, Masuyoshi Saito, Hironori Ishiguchi, Takahiro Yano, Takahiro Sugiyama, Hiroaki Hemmi, Takashi Tanaka, Eri Hamada, Takeshi Hirashima, Ryuichi Amakawa, Shirou Fukuhara, Shosaku Nomura, Tomoki Ito, Tsuneyasu Kaisho

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Understanding dendritic cell (DC) subset functions should lead to the development of novel types of vaccine. Here we characterized expression of XC chemokine receptor 1 (XCR1) and its ligand, XCL1. Murine XCR1 was the only chemokine receptor selectively expressed in CD8α⁺ conventional DCs. XCL1 was constitutively expressed in NK cells, which contribute to serum XCL1 levels. NK and CD8⁺ T cells increased XCL1 production upon activation. These expression patterns were conserved in human blood cells, including the BDCA3⁺ DC subset. Thus, in human and mice, certain DC subsets should be chemotactic towards NK or activated CD8⁺ T cells through XCR1.

Original language	English
Pages (from-to)	756-761
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	397
Issue number	4
DOIs	https://doi.org/10.1016/j.bbrc.2010.06.029
Publication status	Published - Jul 2010
Externally published	Yes

Keywords

Chemokine
Dendritic cells
XCL1
XCR1

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bbrc.2010.06.029

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Yamazaki, C., Miyamoto, R., Hoshino, K., Fukuda, Y., Sasaki, I., Saito, M., Ishiguchi, H., Yano, T., Sugiyama, T., Hemmi, H., Tanaka, T., Hamada, E., Hirashima, T., Amakawa, R., Fukuhara, S., Nomura, S., Ito, T., & Kaisho, T. (2010). Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice. Biochemical and Biophysical Research Communications, 397(4), 756-761. https://doi.org/10.1016/j.bbrc.2010.06.029

Yamazaki, C, Miyamoto, R, Hoshino, K, Fukuda, Y, Sasaki, I, Saito, M, Ishiguchi, H, Yano, T, Sugiyama, T, Hemmi, H, Tanaka, T, Hamada, E, Hirashima, T, Amakawa, R, Fukuhara, S, Nomura, S, Ito, T & Kaisho, T 2010, 'Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice', Biochemical and Biophysical Research Communications, vol. 397, no. 4, pp. 756-761. https://doi.org/10.1016/j.bbrc.2010.06.029

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title = "Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice",

abstract = "Understanding dendritic cell (DC) subset functions should lead to the development of novel types of vaccine. Here we characterized expression of XC chemokine receptor 1 (XCR1) and its ligand, XCL1. Murine XCR1 was the only chemokine receptor selectively expressed in CD8α+ conventional DCs. XCL1 was constitutively expressed in NK cells, which contribute to serum XCL1 levels. NK and CD8+ T cells increased XCL1 production upon activation. These expression patterns were conserved in human blood cells, including the BDCA3+ DC subset. Thus, in human and mice, certain DC subsets should be chemotactic towards NK or activated CD8+ T cells through XCR1.",

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author = "Chihiro Yamazaki and Rie Miyamoto and Katsuaki Hoshino and Yuri Fukuda and Izumi Sasaki and Masuyoshi Saito and Hironori Ishiguchi and Takahiro Yano and Takahiro Sugiyama and Hiroaki Hemmi and Takashi Tanaka and Eri Hamada and Takeshi Hirashima and Ryuichi Amakawa and Shirou Fukuhara and Shosaku Nomura and Tomoki Ito and Tsuneyasu Kaisho",

note = "Funding Information: We thank N. Iwami and E. Haga for technical assistance and S. Haraguchi for secretarial assistance. This work was supported by grants from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) and Japan Society for the Promotion of Science (JSPS), the Takeda Science Foundation, the Mochida Memorial Foundation for Medical and Pharmaceutical Research, and Japan Intractable Diseases Research Foundation. C.Y. and I.S. are RIKEN Junior Research Associates. ",

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doi = "10.1016/j.bbrc.2010.06.029",

language = "English",

volume = "397",

pages = "756--761",

journal = "Biochemical and Biophysical Research Communications",

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AU - Yamazaki, Chihiro

AU - Miyamoto, Rie

AU - Hoshino, Katsuaki

AU - Fukuda, Yuri

AU - Sasaki, Izumi

AU - Saito, Masuyoshi

AU - Ishiguchi, Hironori

AU - Yano, Takahiro

AU - Sugiyama, Takahiro

AU - Hemmi, Hiroaki

AU - Tanaka, Takashi

AU - Hamada, Eri

AU - Hirashima, Takeshi

AU - Amakawa, Ryuichi

AU - Fukuhara, Shirou

AU - Nomura, Shosaku

AU - Ito, Tomoki

AU - Kaisho, Tsuneyasu

N1 - Funding Information: We thank N. Iwami and E. Haga for technical assistance and S. Haraguchi for secretarial assistance. This work was supported by grants from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) and Japan Society for the Promotion of Science (JSPS), the Takeda Science Foundation, the Mochida Memorial Foundation for Medical and Pharmaceutical Research, and Japan Intractable Diseases Research Foundation. C.Y. and I.S. are RIKEN Junior Research Associates.

PY - 2010/7

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N2 - Understanding dendritic cell (DC) subset functions should lead to the development of novel types of vaccine. Here we characterized expression of XC chemokine receptor 1 (XCR1) and its ligand, XCL1. Murine XCR1 was the only chemokine receptor selectively expressed in CD8α+ conventional DCs. XCL1 was constitutively expressed in NK cells, which contribute to serum XCL1 levels. NK and CD8+ T cells increased XCL1 production upon activation. These expression patterns were conserved in human blood cells, including the BDCA3+ DC subset. Thus, in human and mice, certain DC subsets should be chemotactic towards NK or activated CD8+ T cells through XCR1.

AB - Understanding dendritic cell (DC) subset functions should lead to the development of novel types of vaccine. Here we characterized expression of XC chemokine receptor 1 (XCR1) and its ligand, XCL1. Murine XCR1 was the only chemokine receptor selectively expressed in CD8α+ conventional DCs. XCL1 was constitutively expressed in NK cells, which contribute to serum XCL1 levels. NK and CD8+ T cells increased XCL1 production upon activation. These expression patterns were conserved in human blood cells, including the BDCA3+ DC subset. Thus, in human and mice, certain DC subsets should be chemotactic towards NK or activated CD8+ T cells through XCR1.

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KW - Dendritic cells

KW - XCL1

KW - XCR1

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Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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