Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice

Chihiro Yamazaki; Rie Miyamoto; Katsuaki Hoshino; Yuri Fukuda; Izumi Sasaki; Masuyoshi Saito; Hironori Ishiguchi; Takahiro Yano; Takahiro Sugiyama; Hiroaki Hemmi; Takashi Tanaka; Eri Hamada; Takeshi Hirashima; Ryuichi Amakawa; Shirou Fukuhara; Shosaku Nomura; Tomoki Ito; Tsuneyasu Kaisho

doi:10.1016/j.bbrc.2010.06.029

Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice

Chihiro Yamazaki, Rie Miyamoto, Katsuaki Hoshino, Yuri Fukuda, Izumi Sasaki, Masuyoshi Saito, Hironori Ishiguchi, Takahiro Yano, Takahiro Sugiyama, Hiroaki Hemmi, Takashi Tanaka, Eri Hamada, Takeshi Hirashima, Ryuichi Amakawa, Shirou Fukuhara, Shosaku Nomura, Tomoki Ito, Tsuneyasu Kaisho

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Understanding dendritic cell (DC) subset functions should lead to the development of novel types of vaccine. Here we characterized expression of XC chemokine receptor 1 (XCR1) and its ligand, XCL1. Murine XCR1 was the only chemokine receptor selectively expressed in CD8α⁺ conventional DCs. XCL1 was constitutively expressed in NK cells, which contribute to serum XCL1 levels. NK and CD8⁺ T cells increased XCL1 production upon activation. These expression patterns were conserved in human blood cells, including the BDCA3⁺ DC subset. Thus, in human and mice, certain DC subsets should be chemotactic towards NK or activated CD8⁺ T cells through XCR1.

Original language	English
Pages (from-to)	756-761
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	397
Issue number	4
DOIs	https://doi.org/10.1016/j.bbrc.2010.06.029
Publication status	Published - Jul 2010

Keywords

Chemokine
Dendritic cells
XCL1
XCR1

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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Yamazaki, C., Miyamoto, R., Hoshino, K., Fukuda, Y., Sasaki, I., Saito, M., Ishiguchi, H., Yano, T., Sugiyama, T., Hemmi, H., Tanaka, T., Hamada, E., Hirashima, T., Amakawa, R., Fukuhara, S., Nomura, S., Ito, T., & Kaisho, T. (2010). Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice. Biochemical and Biophysical Research Communications, 397(4), 756-761. https://doi.org/10.1016/j.bbrc.2010.06.029

Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice. / Yamazaki, Chihiro; Miyamoto, Rie; Hoshino, Katsuaki; Fukuda, Yuri; Sasaki, Izumi; Saito, Masuyoshi; Ishiguchi, Hironori; Yano, Takahiro; Sugiyama, Takahiro; Hemmi, Hiroaki; Tanaka, Takashi; Hamada, Eri; Hirashima, Takeshi; Amakawa, Ryuichi; Fukuhara, Shirou; Nomura, Shosaku; Ito, Tomoki; Kaisho, Tsuneyasu.

In: Biochemical and Biophysical Research Communications, Vol. 397, No. 4, 07.2010, p. 756-761.

Research output: Contribution to journal › Article › peer-review

Yamazaki, C, Miyamoto, R, Hoshino, K, Fukuda, Y, Sasaki, I, Saito, M, Ishiguchi, H, Yano, T, Sugiyama, T, Hemmi, H, Tanaka, T, Hamada, E, Hirashima, T, Amakawa, R, Fukuhara, S, Nomura, S, Ito, T & Kaisho, T 2010, 'Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice', Biochemical and Biophysical Research Communications, vol. 397, no. 4, pp. 756-761. https://doi.org/10.1016/j.bbrc.2010.06.029

Yamazaki, Chihiro ; Miyamoto, Rie ; Hoshino, Katsuaki ; Fukuda, Yuri ; Sasaki, Izumi ; Saito, Masuyoshi ; Ishiguchi, Hironori ; Yano, Takahiro ; Sugiyama, Takahiro ; Hemmi, Hiroaki ; Tanaka, Takashi ; Hamada, Eri ; Hirashima, Takeshi ; Amakawa, Ryuichi ; Fukuhara, Shirou ; Nomura, Shosaku ; Ito, Tomoki ; Kaisho, Tsuneyasu. / Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice. In: Biochemical and Biophysical Research Communications. 2010 ; Vol. 397, No. 4. pp. 756-761.

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abstract = "Understanding dendritic cell (DC) subset functions should lead to the development of novel types of vaccine. Here we characterized expression of XC chemokine receptor 1 (XCR1) and its ligand, XCL1. Murine XCR1 was the only chemokine receptor selectively expressed in CD8α+ conventional DCs. XCL1 was constitutively expressed in NK cells, which contribute to serum XCL1 levels. NK and CD8+ T cells increased XCL1 production upon activation. These expression patterns were conserved in human blood cells, including the BDCA3+ DC subset. Thus, in human and mice, certain DC subsets should be chemotactic towards NK or activated CD8+ T cells through XCR1.",

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AU - Sasaki, Izumi

AU - Saito, Masuyoshi

AU - Ishiguchi, Hironori

AU - Yano, Takahiro

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AU - Tanaka, Takashi

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AU - Hirashima, Takeshi

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AU - Nomura, Shosaku

AU - Ito, Tomoki

AU - Kaisho, Tsuneyasu

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Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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