Understanding dendritic cell (DC) subset functions should lead to the development of novel types of vaccine. Here we characterized expression of XC chemokine receptor 1 (XCR1) and its ligand, XCL1. Murine XCR1 was the only chemokine receptor selectively expressed in CD8α+ conventional DCs. XCL1 was constitutively expressed in NK cells, which contribute to serum XCL1 levels. NK and CD8+ T cells increased XCL1 production upon activation. These expression patterns were conserved in human blood cells, including the BDCA3+ DC subset. Thus, in human and mice, certain DC subsets should be chemotactic towards NK or activated CD8+ T cells through XCR1.
|Number of pages||6|
|Journal||Biochemical and Biophysical Research Communications|
|Publication status||Published - Jul 1 2010|
- Dendritic cells
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology