Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice

Chihiro Yamazaki, Rie Miyamoto, Katsuaki Hoshino, Yuri Fukuda, Izumi Sasaki, Masuyoshi Saito, Hironori Ishiguchi, Takahiro Yano, Takahiro Sugiyama, Hiroaki Hemmi, Takashi Tanaka, Eri Hamada, Takeshi Hirashima, Ryuichi Amakawa, Shirou Fukuhara, Shosaku Nomura, Tomoki Ito, Tsuneyasu Kaisho

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)


Understanding dendritic cell (DC) subset functions should lead to the development of novel types of vaccine. Here we characterized expression of XC chemokine receptor 1 (XCR1) and its ligand, XCL1. Murine XCR1 was the only chemokine receptor selectively expressed in CD8α+ conventional DCs. XCL1 was constitutively expressed in NK cells, which contribute to serum XCL1 levels. NK and CD8+ T cells increased XCL1 production upon activation. These expression patterns were conserved in human blood cells, including the BDCA3+ DC subset. Thus, in human and mice, certain DC subsets should be chemotactic towards NK or activated CD8+ T cells through XCR1.

Original languageEnglish
Pages (from-to)756-761
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number4
Publication statusPublished - Jul 2010
Externally publishedYes


  • Chemokine
  • Dendritic cells
  • XCL1
  • XCR1

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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