Connective tissue growth factor as a major angiogenic agent that is induced by hypoxia in a human breast cancer cell line

Tsuyoshi Shimo; Satoshi Kubota; Seiji Kondo; Tohru Nakanishi; Akira Sasaki; Hiroshi Mese; Tomohiro Matsumura; Masaharu Takigawa

doi:10.1016/S0304-3835(01)00683-8

Connective tissue growth factor as a major angiogenic agent that is induced by hypoxia in a human breast cancer cell line

Tsuyoshi Shimo, Satoshi Kubota, Seiji Kondo, Tohru Nakanishi, Akira Sasaki, Hiroshi Mese, Tomohiro Matsumura, Masaharu Takigawa

Research output: Contribution to journal › Article › peer-review

77 Citations (Scopus)

Abstract

Connective tissue growth factor (CTGF) is known to be a potent angiogenic factor. Here, we present the evidence that the hypoxic induction of angiogenesis by human breast cancer cells (MDA-231) can be ascribed at least in part to CTGF. Our results indicate that (i) CTGF is abundantly present in MDA-231 cells in vitro and in vivo, (ii) its secretion is up-regulated by hypoxia, and (iii) its gene expression is enhanced in MDA-231 cells cultured under hypoxic conditions. These data suggest CTGF may stimulate angiogenesis by paracrine mechanisms, thereby contributing to the invasion of breast cancer cells. This is the first evidence that human cancer cells differentially express CTGF protein and mRNA under the control of hypoxic conditions.

Original language	English
Pages (from-to)	57-64
Number of pages	8
Journal	Cancer Letters
Volume	174
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3835(01)00683-8
Publication status	Published - Dec 10 2001

Keywords

Angiogenesis
Breast cancer
Connective tissue growth factor
Hypoxia

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

Access to Document

10.1016/S0304-3835(01)00683-8

Fingerprint Dive into the research topics of 'Connective tissue growth factor as a major angiogenic agent that is induced by hypoxia in a human breast cancer cell line'. Together they form a unique fingerprint.

Cite this

Connective tissue growth factor as a major angiogenic agent that is induced by hypoxia in a human breast cancer cell line. / Shimo, Tsuyoshi; Kubota, Satoshi; Kondo, Seiji; Nakanishi, Tohru; Sasaki, Akira; Mese, Hiroshi; Matsumura, Tomohiro; Takigawa, Masaharu.

In: Cancer Letters, Vol. 174, No. 1, 10.12.2001, p. 57-64.

Research output: Contribution to journal › Article › peer-review

@article{45f24e5848564739a655cec43826fe88,

title = "Connective tissue growth factor as a major angiogenic agent that is induced by hypoxia in a human breast cancer cell line",

abstract = "Connective tissue growth factor (CTGF) is known to be a potent angiogenic factor. Here, we present the evidence that the hypoxic induction of angiogenesis by human breast cancer cells (MDA-231) can be ascribed at least in part to CTGF. Our results indicate that (i) CTGF is abundantly present in MDA-231 cells in vitro and in vivo, (ii) its secretion is up-regulated by hypoxia, and (iii) its gene expression is enhanced in MDA-231 cells cultured under hypoxic conditions. These data suggest CTGF may stimulate angiogenesis by paracrine mechanisms, thereby contributing to the invasion of breast cancer cells. This is the first evidence that human cancer cells differentially express CTGF protein and mRNA under the control of hypoxic conditions.",

keywords = "Angiogenesis, Breast cancer, Connective tissue growth factor, Hypoxia",

author = "Tsuyoshi Shimo and Satoshi Kubota and Seiji Kondo and Tohru Nakanishi and Akira Sasaki and Hiroshi Mese and Tomohiro Matsumura and Masaharu Takigawa",

note = "Funding Information: This work was supported in part by Grants-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture of Japan (S.K., T.N., M.T.) and the Ministry of Health and Welfare's Research Grant for Specific Disease, Japan (M.T.), and grants from the foundation for Growth Science in Japan (M.T.), the Sumitomo Foundation (M.T.) and Research for the Future Programme of The Japan Society for the Promotion of Science (JSPS) (Project: Biological Tissue Engineering, JSPS-RFTF98I00201). The authors wish to thank Drs Takako Hattori, Takashi Nishida, Melinda Yin for helpful suggestions, and Ms Satoko Shimo for secretarial assistance.",

year = "2001",

month = dec,

day = "10",

doi = "10.1016/S0304-3835(01)00683-8",

language = "English",

volume = "174",

pages = "57--64",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - Connective tissue growth factor as a major angiogenic agent that is induced by hypoxia in a human breast cancer cell line

AU - Shimo, Tsuyoshi

AU - Kubota, Satoshi

AU - Kondo, Seiji

AU - Nakanishi, Tohru

AU - Sasaki, Akira

AU - Mese, Hiroshi

AU - Matsumura, Tomohiro

AU - Takigawa, Masaharu

N1 - Funding Information: This work was supported in part by Grants-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture of Japan (S.K., T.N., M.T.) and the Ministry of Health and Welfare's Research Grant for Specific Disease, Japan (M.T.), and grants from the foundation for Growth Science in Japan (M.T.), the Sumitomo Foundation (M.T.) and Research for the Future Programme of The Japan Society for the Promotion of Science (JSPS) (Project: Biological Tissue Engineering, JSPS-RFTF98I00201). The authors wish to thank Drs Takako Hattori, Takashi Nishida, Melinda Yin for helpful suggestions, and Ms Satoko Shimo for secretarial assistance.

PY - 2001/12/10

Y1 - 2001/12/10

N2 - Connective tissue growth factor (CTGF) is known to be a potent angiogenic factor. Here, we present the evidence that the hypoxic induction of angiogenesis by human breast cancer cells (MDA-231) can be ascribed at least in part to CTGF. Our results indicate that (i) CTGF is abundantly present in MDA-231 cells in vitro and in vivo, (ii) its secretion is up-regulated by hypoxia, and (iii) its gene expression is enhanced in MDA-231 cells cultured under hypoxic conditions. These data suggest CTGF may stimulate angiogenesis by paracrine mechanisms, thereby contributing to the invasion of breast cancer cells. This is the first evidence that human cancer cells differentially express CTGF protein and mRNA under the control of hypoxic conditions.

AB - Connective tissue growth factor (CTGF) is known to be a potent angiogenic factor. Here, we present the evidence that the hypoxic induction of angiogenesis by human breast cancer cells (MDA-231) can be ascribed at least in part to CTGF. Our results indicate that (i) CTGF is abundantly present in MDA-231 cells in vitro and in vivo, (ii) its secretion is up-regulated by hypoxia, and (iii) its gene expression is enhanced in MDA-231 cells cultured under hypoxic conditions. These data suggest CTGF may stimulate angiogenesis by paracrine mechanisms, thereby contributing to the invasion of breast cancer cells. This is the first evidence that human cancer cells differentially express CTGF protein and mRNA under the control of hypoxic conditions.

KW - Angiogenesis

KW - Breast cancer

KW - Connective tissue growth factor

KW - Hypoxia

UR - http://www.scopus.com/inward/record.url?scp=0035841946&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035841946&partnerID=8YFLogxK

U2 - 10.1016/S0304-3835(01)00683-8

DO - 10.1016/S0304-3835(01)00683-8

M3 - Article

C2 - 11675152

AN - SCOPUS:0035841946

VL - 174

SP - 57

EP - 64

JO - Cancer Letters

JF - Cancer Letters

SN - 0304-3835

IS - 1

ER -

Connective tissue growth factor as a major angiogenic agent that is induced by hypoxia in a human breast cancer cell line

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Cite this