@article{45f24e5848564739a655cec43826fe88,
title = "Connective tissue growth factor as a major angiogenic agent that is induced by hypoxia in a human breast cancer cell line",
abstract = "Connective tissue growth factor (CTGF) is known to be a potent angiogenic factor. Here, we present the evidence that the hypoxic induction of angiogenesis by human breast cancer cells (MDA-231) can be ascribed at least in part to CTGF. Our results indicate that (i) CTGF is abundantly present in MDA-231 cells in vitro and in vivo, (ii) its secretion is up-regulated by hypoxia, and (iii) its gene expression is enhanced in MDA-231 cells cultured under hypoxic conditions. These data suggest CTGF may stimulate angiogenesis by paracrine mechanisms, thereby contributing to the invasion of breast cancer cells. This is the first evidence that human cancer cells differentially express CTGF protein and mRNA under the control of hypoxic conditions.",
keywords = "Angiogenesis, Breast cancer, Connective tissue growth factor, Hypoxia",
author = "Tsuyoshi Shimo and Satoshi Kubota and Seiji Kondo and Tohru Nakanishi and Akira Sasaki and Hiroshi Mese and Tomohiro Matsumura and Masaharu Takigawa",
note = "Funding Information: This work was supported in part by Grants-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture of Japan (S.K., T.N., M.T.) and the Ministry of Health and Welfare's Research Grant for Specific Disease, Japan (M.T.), and grants from the foundation for Growth Science in Japan (M.T.), the Sumitomo Foundation (M.T.) and Research for the Future Programme of The Japan Society for the Promotion of Science (JSPS) (Project: Biological Tissue Engineering, JSPS-RFTF98I00201). The authors wish to thank Drs Takako Hattori, Takashi Nishida, Melinda Yin for helpful suggestions, and Ms Satoko Shimo for secretarial assistance.",
year = "2001",
month = dec,
day = "10",
doi = "10.1016/S0304-3835(01)00683-8",
language = "English",
volume = "174",
pages = "57--64",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "1",
}
