Conjugate reduction of α,β-unsaturated ketones with hydrosilane mediated by copper(I) salt

Atsunori Mori, Akinori Fujita, Hiroshi Kajiro, Yasushi Nishihara, Tamejiro Hiyama

Research output: Contribution to journalArticlepeer-review

57 Citations (Scopus)

Abstract

Reduction of several α,β-unsaturated ketones with dimethylphenylsilane and 10-100 mol% of CuF(PPh3)3 · 2EtOH or CuCl/PPh3/Bu4NF proceeds in a 1,4-selective manner to give the corresponding saturated ketones in up to >99% yield.

Original languageEnglish
Pages (from-to)4573-4582
Number of pages10
JournalTetrahedron
Volume55
Issue number15
DOIs
Publication statusPublished - Apr 9 1999

Keywords

  • Copper and compounds
  • Ketones
  • Reduction
  • Silicon and compounds

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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