Concurrent hodgkin's disease (mixed cellularity type) and T-cell chronic lymphocytic leukemia/prolymphocytic leukemia

Akira Miyata, Kensuke Kojima, Tadashi Yoshino, Soichirou Fujii, Katsuji Shinagawa, Koichi Ichimura

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We describe a patient with leukopenic T-cell chronic lymphocytic leukemia/prolymphocytic leukemia (T-CLL/PLL), according to the Revised European-American Classification of Lymphoid Neoplasms. This patient simultaneously developed classic Hodgkin's disease (HD), a combination previously unreported.The leukemic cells were small and mature, did not have cytoplasmic granulation, and appeared similar to B-cell chronic lymphocytic leukemia. Immunophenotyping of the bone marrow-infiltrating cells revealed a postthymic suppressor/cytotoxic phenotype of CD2+, CD3+, CD4-, CD5+, CD8+, CD25-, TCR-α β. A lymph node biopsy showed the histological features of HD (mixed cellularity) with infiltrating CD8+ lymphocytes, and immunohistochemical examination revealed the following phenotype of Reed-Sternberg cells: LeuM1/CD15+, Berm/CD30+, L26/PanB-, UCHL-1/CD45RO-, cyCD3-, CD4-, CD8-, CD20-, CD79a-, EMA-, EBER-1+, LMP-1+. Southern blot analysis of the bone marrow and lymph node revealed the same rearrangement of bands of T-cell-receptor genes. Although the HD was treated with chemotherapy that resulted in complete remission, the T-PLL/CLL took an indolent course. This case may suggest the existence of a subtype of T-CLL/PLL with leukopenia and an indolent clinical course. Both diseases were believed to be independent and not a transformation of one to the other.

Original languageEnglish
Pages (from-to)230-235
Number of pages6
JournalInternational Journal of Hematology
Volume73
Issue number2
DOIs
Publication statusPublished - 2001

Fingerprint

Prolymphocytic Leukemia
T-Cell Prolymphocytic Leukemia
Hodgkin Disease
Lymph Nodes
Reed-Sternberg Cells
Phenotype
T-Cell Receptor Genes
Immunophenotyping
Leukopenia
B-Cell Chronic Lymphocytic Leukemia
Southern Blotting
Bone Marrow Cells
Bone Marrow
Lymphocytes
Biopsy
Drug Therapy
Neoplasms

Keywords

  • Hodgkin's disease
  • Indolent course
  • Leukopenia
  • T-cell chronic lymphocytic leukemia/prolymphocytic leukemia

ASJC Scopus subject areas

  • Hematology

Cite this

Concurrent hodgkin's disease (mixed cellularity type) and T-cell chronic lymphocytic leukemia/prolymphocytic leukemia. / Miyata, Akira; Kojima, Kensuke; Yoshino, Tadashi; Fujii, Soichirou; Shinagawa, Katsuji; Ichimura, Koichi.

In: International Journal of Hematology, Vol. 73, No. 2, 2001, p. 230-235.

Research output: Contribution to journalArticle

Miyata, Akira ; Kojima, Kensuke ; Yoshino, Tadashi ; Fujii, Soichirou ; Shinagawa, Katsuji ; Ichimura, Koichi. / Concurrent hodgkin's disease (mixed cellularity type) and T-cell chronic lymphocytic leukemia/prolymphocytic leukemia. In: International Journal of Hematology. 2001 ; Vol. 73, No. 2. pp. 230-235.
@article{a0dace800a7f4d81badf142e401c6471,
title = "Concurrent hodgkin's disease (mixed cellularity type) and T-cell chronic lymphocytic leukemia/prolymphocytic leukemia",
abstract = "We describe a patient with leukopenic T-cell chronic lymphocytic leukemia/prolymphocytic leukemia (T-CLL/PLL), according to the Revised European-American Classification of Lymphoid Neoplasms. This patient simultaneously developed classic Hodgkin's disease (HD), a combination previously unreported.The leukemic cells were small and mature, did not have cytoplasmic granulation, and appeared similar to B-cell chronic lymphocytic leukemia. Immunophenotyping of the bone marrow-infiltrating cells revealed a postthymic suppressor/cytotoxic phenotype of CD2+, CD3+, CD4-, CD5+, CD8+, CD25-, TCR-α β. A lymph node biopsy showed the histological features of HD (mixed cellularity) with infiltrating CD8+ lymphocytes, and immunohistochemical examination revealed the following phenotype of Reed-Sternberg cells: LeuM1/CD15+, Berm/CD30+, L26/PanB-, UCHL-1/CD45RO-, cyCD3-, CD4-, CD8-, CD20-, CD79a-, EMA-, EBER-1+, LMP-1+. Southern blot analysis of the bone marrow and lymph node revealed the same rearrangement of bands of T-cell-receptor genes. Although the HD was treated with chemotherapy that resulted in complete remission, the T-PLL/CLL took an indolent course. This case may suggest the existence of a subtype of T-CLL/PLL with leukopenia and an indolent clinical course. Both diseases were believed to be independent and not a transformation of one to the other.",
keywords = "Hodgkin's disease, Indolent course, Leukopenia, T-cell chronic lymphocytic leukemia/prolymphocytic leukemia",
author = "Akira Miyata and Kensuke Kojima and Tadashi Yoshino and Soichirou Fujii and Katsuji Shinagawa and Koichi Ichimura",
year = "2001",
doi = "10.1007/BF02981943",
language = "English",
volume = "73",
pages = "230--235",
journal = "International Journal of Hematology",
issn = "0925-5710",
publisher = "Springer Japan",
number = "2",

}

TY - JOUR

T1 - Concurrent hodgkin's disease (mixed cellularity type) and T-cell chronic lymphocytic leukemia/prolymphocytic leukemia

AU - Miyata, Akira

AU - Kojima, Kensuke

AU - Yoshino, Tadashi

AU - Fujii, Soichirou

AU - Shinagawa, Katsuji

AU - Ichimura, Koichi

PY - 2001

Y1 - 2001

N2 - We describe a patient with leukopenic T-cell chronic lymphocytic leukemia/prolymphocytic leukemia (T-CLL/PLL), according to the Revised European-American Classification of Lymphoid Neoplasms. This patient simultaneously developed classic Hodgkin's disease (HD), a combination previously unreported.The leukemic cells were small and mature, did not have cytoplasmic granulation, and appeared similar to B-cell chronic lymphocytic leukemia. Immunophenotyping of the bone marrow-infiltrating cells revealed a postthymic suppressor/cytotoxic phenotype of CD2+, CD3+, CD4-, CD5+, CD8+, CD25-, TCR-α β. A lymph node biopsy showed the histological features of HD (mixed cellularity) with infiltrating CD8+ lymphocytes, and immunohistochemical examination revealed the following phenotype of Reed-Sternberg cells: LeuM1/CD15+, Berm/CD30+, L26/PanB-, UCHL-1/CD45RO-, cyCD3-, CD4-, CD8-, CD20-, CD79a-, EMA-, EBER-1+, LMP-1+. Southern blot analysis of the bone marrow and lymph node revealed the same rearrangement of bands of T-cell-receptor genes. Although the HD was treated with chemotherapy that resulted in complete remission, the T-PLL/CLL took an indolent course. This case may suggest the existence of a subtype of T-CLL/PLL with leukopenia and an indolent clinical course. Both diseases were believed to be independent and not a transformation of one to the other.

AB - We describe a patient with leukopenic T-cell chronic lymphocytic leukemia/prolymphocytic leukemia (T-CLL/PLL), according to the Revised European-American Classification of Lymphoid Neoplasms. This patient simultaneously developed classic Hodgkin's disease (HD), a combination previously unreported.The leukemic cells were small and mature, did not have cytoplasmic granulation, and appeared similar to B-cell chronic lymphocytic leukemia. Immunophenotyping of the bone marrow-infiltrating cells revealed a postthymic suppressor/cytotoxic phenotype of CD2+, CD3+, CD4-, CD5+, CD8+, CD25-, TCR-α β. A lymph node biopsy showed the histological features of HD (mixed cellularity) with infiltrating CD8+ lymphocytes, and immunohistochemical examination revealed the following phenotype of Reed-Sternberg cells: LeuM1/CD15+, Berm/CD30+, L26/PanB-, UCHL-1/CD45RO-, cyCD3-, CD4-, CD8-, CD20-, CD79a-, EMA-, EBER-1+, LMP-1+. Southern blot analysis of the bone marrow and lymph node revealed the same rearrangement of bands of T-cell-receptor genes. Although the HD was treated with chemotherapy that resulted in complete remission, the T-PLL/CLL took an indolent course. This case may suggest the existence of a subtype of T-CLL/PLL with leukopenia and an indolent clinical course. Both diseases were believed to be independent and not a transformation of one to the other.

KW - Hodgkin's disease

KW - Indolent course

KW - Leukopenia

KW - T-cell chronic lymphocytic leukemia/prolymphocytic leukemia

UR - http://www.scopus.com/inward/record.url?scp=0035258115&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035258115&partnerID=8YFLogxK

U2 - 10.1007/BF02981943

DO - 10.1007/BF02981943

M3 - Article

VL - 73

SP - 230

EP - 235

JO - International Journal of Hematology

JF - International Journal of Hematology

SN - 0925-5710

IS - 2

ER -