Abstract
Recently, attempts have made to use radiotherapy in combination with chemotherapy in various solid tumors including cervical cancer. Twenty-four patients with locally advanced cervical cancer were treated with concurrent Carboplatin (16-24 mg/m2/day) or Nedaplatin (20 mg/m2/week) and conventional radiotherapy. Of 13 evaluable patients, there were nine complete responders and four partial responders. There was no renal damage or grade 4 hematological toxicity. Gastrointestinal adverse reactions were mild. One patient had grade 3 dermatologic toxicity after delayed radiation therapy. This pilot study suggests that daily Carboplatin or weekly Nedaplatin administered with standard radiation therapy is safe, well-tolerated, and thus may be useful as a radiation sensitizer in the treatment of locally advanced cervical cancer.
Original language | English |
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Pages (from-to) | 351-355 |
Number of pages | 5 |
Journal | Gan to kagaku ryoho. Cancer & chemotherapy |
Volume | 28 |
Issue number | 3 |
Publication status | Published - Mar 2001 |
ASJC Scopus subject areas
- Oncology
- Cancer Research