Concise synthesis of tetrahydrophenanthridone by palladium reagent

Takashi Harayama, Hiroko Toko, Hiromi Nishioka, Hitoshi Abe, Yasuo Takeuchi

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Heck reaction of N-(2-halophenyl)-N-methyl-1-cyclohexene-1carboxamide (1) and 2-bromo-N-methyl-N-phenyl-1-cyclohexene-1-carboxamide (4) using a palladium reagent under several reaction conditions was examined. Reaction of 4 using Pd(OAc)2, DPPP, and Bu3P afforded tetrahydrophenanthridone (5) in excellent yield.

Original languageEnglish
Pages (from-to)541-546
Number of pages6
JournalHeterocycles
Volume59
Issue number2
DOIs
Publication statusPublished - Mar 1 2003

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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