Concise synthesis of pyrrolophenanthridine alkaloids using a Pd-catalyzed biaryl coupling reaction with regioselective C-H activation

Takashi Harayama, Akihiro Hori, Hitoshi Abe, Yasuo Takeuchi

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The concise synthesis of the pyrrolophenanthridine alkaloids such as anhydrolycorine, assoanine, anhydrolycorin-7-one, and oxoassoanine, was achieved using the Pd-catalyzed biaryl coupling reaction of 1-(2-halobenzyl)-2,3-dihydroindole by applying the regioselective C-H activation method with intramolecular coordination of the benzylamino group to Pd.

Original languageEnglish
Pages (from-to)2429-2434
Number of pages6
JournalHeterocycles
Volume60
Issue number11
DOIs
Publication statusPublished - Nov 1 2003

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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