Concise synthesis of fagaridine and decarine, phenolic benzo[c]phenanthridine alkaloids, using the palladium-assisted biaryl coupling reaction

Takashi Harayama, Tomonori Sato, Yuichiro Nakano, Hitoshi Abe, Yasuo Takeuchi

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Total synthesis of fagaridine (5) and decarine (6), phenolic benzo[c]phenanthridine alkaloids, was accomplished via the aryl-aryl coupling reaction of bromo amides protected by an isopropyl group with palladium, followed by reduction with LiAlH4 and treatment with conc. HCl.

Original languageEnglish
Pages (from-to)293-301
Number of pages9
JournalHeterocycles
Volume59
Issue number1
DOIs
Publication statusPublished - Jan 1 2003

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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