Concise synthesis of dl-febrifugine

Yasuo Takeuchi; Miyo Oshige; Kumiko Azuma; Hitoshi Abe; Takashi Harayama

doi:10.1248/cpb.53.868

Concise synthesis of dl-febrifugine

Yasuo Takeuchi, Miyo Oshige, Kumiko Azuma, Hitoshi Abe, Takashi Harayama

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Racemic compound (1) of the antimalarial agents febrifugine (d-1) was synthesized using an stereoselective Michael reaction of an ω-amidoenone (5) which was prepared by the Wittig reaction of piperidinediol (7).

Original language	English
Pages (from-to)	868-869
Number of pages	2
Journal	Chemical and Pharmaceutical Bulletin
Volume	53
Issue number	7
DOIs	https://doi.org/10.1248/cpb.53.868
Publication status	Published - Jul 2005

Keywords

Antimalarial activity
Febrifugine
Stereoselective Michael reaction
Total synthesis
Wittig reaction

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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title = "Concise synthesis of dl-febrifugine",

abstract = "Racemic compound (1) of the antimalarial agents febrifugine (d-1) was synthesized using an stereoselective Michael reaction of an ω-amidoenone (5) which was prepared by the Wittig reaction of piperidinediol (7).",

keywords = "Antimalarial activity, Febrifugine, Stereoselective Michael reaction, Total synthesis, Wittig reaction",

author = "Yasuo Takeuchi and Miyo Oshige and Kumiko Azuma and Hitoshi Abe and Takashi Harayama",

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AU - Oshige, Miyo

AU - Azuma, Kumiko

AU - Abe, Hitoshi

AU - Harayama, Takashi

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KW - Febrifugine

KW - Stereoselective Michael reaction

KW - Total synthesis

KW - Wittig reaction

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