Concise synthesis of dl-febrifugine

Yasuo Takeuchi, Miyo Oshige, Kumiko Azuma, Hitoshi Abe, Takashi Harayama

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Racemic compound (1) of the antimalarial agents febrifugine (d-1) was synthesized using an stereoselective Michael reaction of an ω-amidoenone (5) which was prepared by the Wittig reaction of piperidinediol (7).

Original languageEnglish
Pages (from-to)868-869
Number of pages2
JournalChemical and Pharmaceutical Bulletin
Volume53
Issue number7
DOIs
Publication statusPublished - Jul 2005

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Imino Pyranoses
Antimalarials
febrifugine

Keywords

  • Antimalarial activity
  • Febrifugine
  • Stereoselective Michael reaction
  • Total synthesis
  • Wittig reaction

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

Cite this

Concise synthesis of dl-febrifugine. / Takeuchi, Yasuo; Oshige, Miyo; Azuma, Kumiko; Abe, Hitoshi; Harayama, Takashi.

In: Chemical and Pharmaceutical Bulletin, Vol. 53, No. 7, 07.2005, p. 868-869.

Research output: Contribution to journalArticle

Takeuchi, Y, Oshige, M, Azuma, K, Abe, H & Harayama, T 2005, 'Concise synthesis of dl-febrifugine', Chemical and Pharmaceutical Bulletin, vol. 53, no. 7, pp. 868-869. https://doi.org/10.1248/cpb.53.868
Takeuchi, Yasuo ; Oshige, Miyo ; Azuma, Kumiko ; Abe, Hitoshi ; Harayama, Takashi. / Concise synthesis of dl-febrifugine. In: Chemical and Pharmaceutical Bulletin. 2005 ; Vol. 53, No. 7. pp. 868-869.
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