Concise synthesis of dl-febrifugine

Yasuo Takeuchi, Miyo Oshige, Kumiko Azuma, Hitoshi Abe, Takashi Harayama

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Racemic compound (1) of the antimalarial agents febrifugine (d-1) was synthesized using an stereoselective Michael reaction of an ω-amidoenone (5) which was prepared by the Wittig reaction of piperidinediol (7).

Original languageEnglish
Pages (from-to)868-869
Number of pages2
JournalChemical and Pharmaceutical Bulletin
Volume53
Issue number7
DOIs
Publication statusPublished - Jul 1 2005

Keywords

  • Antimalarial activity
  • Febrifugine
  • Stereoselective Michael reaction
  • Total synthesis
  • Wittig reaction

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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