Concise synthesis of dl-febrifugine

Yasuo Takeuchi; Miyo Oshige; Kumiko Azuma; Hitoshi Abe; Takashi Harayama

doi:10.1248/cpb.53.868

Concise synthesis of dl-febrifugine

Yasuo Takeuchi, Miyo Oshige, Kumiko Azuma, Hitoshi Abe, Takashi Harayama

Research output: Contribution to journal › Article

19 Citations (Scopus)

Abstract

Racemic compound (1) of the antimalarial agents febrifugine (d-1) was synthesized using an stereoselective Michael reaction of an ω-amidoenone (5) which was prepared by the Wittig reaction of piperidinediol (7).

Original language	English
Pages (from-to)	868-869
Number of pages	2
Journal	Chemical and Pharmaceutical Bulletin
Volume	53
Issue number	7
DOIs	https://doi.org/10.1248/cpb.53.868
Publication status	Published - Jul 1 2005

Keywords

Antimalarial activity
Febrifugine
Stereoselective Michael reaction
Total synthesis
Wittig reaction

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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Takeuchi, Y., Oshige, M., Azuma, K., Abe, H., & Harayama, T. (2005). Concise synthesis of dl-febrifugine. Chemical and Pharmaceutical Bulletin, 53(7), 868-869. https://doi.org/10.1248/cpb.53.868

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