Concise synthesis of cyclic ethers via the palladium-catalyzed coupling of ketene acetal triflates and a zinc homoenolate. Synthesis of the DE and GH ring segments of gambierol

Isao Kadota, Hiroyoshi Takamura, Kumi Sato, Yoshinori Yamamoto

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Concise syntheses of the DE and GH ring segments of gambierol (1) were achieved by the palladium-catalyzed coupling of ketene acetal triflates and a zinc homoenolate, followed by the hydroboration of the resulting cyclic enol ethers and subsequent lactonization.

Original languageEnglish
Pages (from-to)4729-4731
Number of pages3
JournalTetrahedron Letters
Volume42
Issue number28
DOIs
Publication statusPublished - Jul 9 2001
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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