Concise synthesis of a highly functionalized cyclopentane segment: toward the total synthesis of kansuinine A

Kenichiro Shimokawa, Hiroyoshi Takamura, Daisuke Uemura

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Kansuinine A, isolated from the plant Euphorbia kansui Liou, is one of a series of jatrophane diterpenes that have novel structural features, which include contiguous stereocenters, a highly oxygenated carbon framework, and a tricyclic ring system. We describe here a short and concise synthesis of the cyclopentane segment of kansuinine A via SmI2-mediated cyclization of δ-iodoester as a key construction method.

Original languageEnglish
Pages (from-to)5623-5625
Number of pages3
JournalTetrahedron Letters
Volume48
Issue number32
DOIs
Publication statusPublished - Aug 6 2007
Externally publishedYes

Fingerprint

Euphorbia
Cyclopentanes
Diterpenes
Cyclization
Carbon
jatrophane

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Concise synthesis of a highly functionalized cyclopentane segment : toward the total synthesis of kansuinine A. / Shimokawa, Kenichiro; Takamura, Hiroyoshi; Uemura, Daisuke.

In: Tetrahedron Letters, Vol. 48, No. 32, 06.08.2007, p. 5623-5625.

Research output: Contribution to journalArticle

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