Concise synthesis of a highly functionalized cyclopentane segment: toward the total synthesis of kansuinine A

Kenichiro Shimokawa, Hiroyoshi Takamura, Daisuke Uemura

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Kansuinine A, isolated from the plant Euphorbia kansui Liou, is one of a series of jatrophane diterpenes that have novel structural features, which include contiguous stereocenters, a highly oxygenated carbon framework, and a tricyclic ring system. We describe here a short and concise synthesis of the cyclopentane segment of kansuinine A via SmI2-mediated cyclization of δ-iodoester as a key construction method.

Original languageEnglish
Pages (from-to)5623-5625
Number of pages3
JournalTetrahedron Letters
Volume48
Issue number32
DOIs
Publication statusPublished - Aug 6 2007
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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