TY - JOUR
T1 - Concise synthesis of a highly functionalized cyclopentane segment
T2 - toward the total synthesis of kansuinine A
AU - Shimokawa, Kenichiro
AU - Takamura, Hiroyoshi
AU - Uemura, Daisuke
N1 - Funding Information:
This study was supported in part by Grants-in-Aid for Scientific Research for Creative Scientific Research (16GS0206) and the 21st century COE program (Establishment of COE on Materials Science) from the Ministry of Education, Culture, Sports, Science and Technology, Japan. We are also indebted to Ono Pharmaceutical Co., Ltd for their financial support.
PY - 2007/8/6
Y1 - 2007/8/6
N2 - Kansuinine A, isolated from the plant Euphorbia kansui Liou, is one of a series of jatrophane diterpenes that have novel structural features, which include contiguous stereocenters, a highly oxygenated carbon framework, and a tricyclic ring system. We describe here a short and concise synthesis of the cyclopentane segment of kansuinine A via SmI2-mediated cyclization of δ-iodoester as a key construction method.
AB - Kansuinine A, isolated from the plant Euphorbia kansui Liou, is one of a series of jatrophane diterpenes that have novel structural features, which include contiguous stereocenters, a highly oxygenated carbon framework, and a tricyclic ring system. We describe here a short and concise synthesis of the cyclopentane segment of kansuinine A via SmI2-mediated cyclization of δ-iodoester as a key construction method.
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U2 - 10.1016/j.tetlet.2007.06.046
DO - 10.1016/j.tetlet.2007.06.046
M3 - Article
AN - SCOPUS:34447288681
SN - 0040-4039
VL - 48
SP - 5623
EP - 5625
JO - Tetrahedron Letters
JF - Tetrahedron Letters
IS - 32
ER -