Concise and efficient asymmetric synthesis of (S)-2-ethylphenylpropanoic acid derivatives: Dual agonists for human peroxisome proliferator-activated receptor α and δ

Jun Ichi Kasuga; Yuichi Hashimoto; Hiroyuki Miyachi

doi:10.1016/j.bmcl.2005.11.029

Concise and efficient asymmetric synthesis of (S)-2-ethylphenylpropanoic acid derivatives: Dual agonists for human peroxisome proliferator-activated receptor α and δ

Jun Ichi Kasuga, Yuichi Hashimoto, Hiroyuki Miyachi

Research output: Contribution to journal › Article

20 Citations (Scopus)

Abstract

Optically active (S)-2-ethylphenylpropanoic acid derivatives, dual agonists for human peroxisome proliferator-activated receptor (PPAR) α and δ, were efficiently prepared by using Evan's chiral oxazolidinone technique and reductive amide N-alkylation as key steps.

Original language	English
Pages (from-to)	771-774
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	16
Issue number	4
DOIs	https://doi.org/10.1016/j.bmcl.2005.11.029
Publication status	Published - Feb 15 2006
Externally published	Yes

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Keywords

Metabolic syndrome
PPARα
PPARδ
Reductive amide alkylation

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Organic Chemistry
Drug Discovery
Pharmaceutical Science

Cite this

Kasuga, J. I., Hashimoto, Y., & Miyachi, H. (2006). Concise and efficient asymmetric synthesis of (S)-2-ethylphenylpropanoic acid derivatives: Dual agonists for human peroxisome proliferator-activated receptor α and δ. Bioorganic and Medicinal Chemistry Letters, 16(4), 771-774. https://doi.org/10.1016/j.bmcl.2005.11.029

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10.1016/j.bmcl.2005.11.029