Concise and efficient asymmetric synthesis of (S)-2-ethylphenylpropanoic acid derivatives: Dual agonists for human peroxisome proliferator-activated receptor α and δ

Jun Ichi Kasuga; Yuichi Hashimoto; Hiroyuki Miyachi

doi:10.1016/j.bmcl.2005.11.029

Concise and efficient asymmetric synthesis of (S)-2-ethylphenylpropanoic acid derivatives: Dual agonists for human peroxisome proliferator-activated receptor α and δ

Jun Ichi Kasuga, Yuichi Hashimoto, Hiroyuki Miyachi

Faculty of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Optically active (S)-2-ethylphenylpropanoic acid derivatives, dual agonists for human peroxisome proliferator-activated receptor (PPAR) α and δ, were efficiently prepared by using Evan's chiral oxazolidinone technique and reductive amide N-alkylation as key steps.

Original language	English
Pages (from-to)	771-774
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	16
Issue number	4
DOIs	https://doi.org/10.1016/j.bmcl.2005.11.029
Publication status	Published - Feb 15 2006

Keywords

Metabolic syndrome
PPARα
PPARδ
Reductive amide alkylation

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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Concise and efficient asymmetric synthesis of (S)-2-ethylphenylpropanoic acid derivatives : Dual agonists for human peroxisome proliferator-activated receptor α and δ. / Kasuga, Jun Ichi; Hashimoto, Yuichi; Miyachi, Hiroyuki.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 16, No. 4, 15.02.2006, p. 771-774.

Research output: Contribution to journal › Article › peer-review

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abstract = "Optically active (S)-2-ethylphenylpropanoic acid derivatives, dual agonists for human peroxisome proliferator-activated receptor (PPAR) α and δ, were efficiently prepared by using Evan's chiral oxazolidinone technique and reductive amide N-alkylation as key steps.",

keywords = "Metabolic syndrome, PPARα, PPARδ, Reductive amide alkylation",

author = "Kasuga, {Jun Ichi} and Yuichi Hashimoto and Hiroyuki Miyachi",

note = "Funding Information: The work described in this paper was partially supported by Grants-in-Aid for Scientific Research from The Ministry of Education, Culture, Sports, Science and Technology, Japan, and the Japan Society for the Promotion of Science. ",

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AU - Kasuga, Jun Ichi

AU - Hashimoto, Yuichi

AU - Miyachi, Hiroyuki

N1 - Funding Information: The work described in this paper was partially supported by Grants-in-Aid for Scientific Research from The Ministry of Education, Culture, Sports, Science and Technology, Japan, and the Japan Society for the Promotion of Science.

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Concise and efficient asymmetric synthesis of (S)-2-ethylphenylpropanoic acid derivatives: Dual agonists for human peroxisome proliferator-activated receptor α and δ

Abstract

Keywords

ASJC Scopus subject areas

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