Concise and efficient asymmetric synthesis of (S)-2-ethylphenylpropanoic acid derivatives

Dual agonists for human peroxisome proliferator-activated receptor α and δ

Jun Ichi Kasuga, Yuichi Hashimoto, Hiroyuki Miyachi

Research output: Contribution to journal › Article

20 Citations (Scopus)

Abstract

Optically active (S)-2-ethylphenylpropanoic acid derivatives, dual agonists for human peroxisome proliferator-activated receptor (PPAR) α and δ, were efficiently prepared by using Evan's chiral oxazolidinone technique and reductive amide N-alkylation as key steps.

Original languageEnglish
Pages (from-to)771-774
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume16
Issue number4
DOIs
Publication statusPublished - Feb 15 2006
Externally publishedYes

Fingerprint

Oxazolidinones
Peroxisome Proliferator-Activated Receptors
Alkylation
Amides
Derivatives
Acids

Keywords

  • Metabolic syndrome
  • PPARα
  • PPARδ
  • Reductive amide alkylation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Concise and efficient asymmetric synthesis of (S)-2-ethylphenylpropanoic acid derivatives : Dual agonists for human peroxisome proliferator-activated receptor α and δ. / Kasuga, Jun Ichi; Hashimoto, Yuichi; Miyachi, Hiroyuki.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 16, No. 4, 15.02.2006, p. 771-774.

Research output: Contribution to journal › Article

Kasuga, JI, Hashimoto, Y & Miyachi, H 2006, 'Concise and efficient asymmetric synthesis of (S)-2-ethylphenylpropanoic acid derivatives: Dual agonists for human peroxisome proliferator-activated receptor α and δ', Bioorganic and Medicinal Chemistry Letters, vol. 16, no. 4, pp. 771-774. https://doi.org/10.1016/j.bmcl.2005.11.029
Kasuga JI, Hashimoto Y, Miyachi H. Concise and efficient asymmetric synthesis of (S)-2-ethylphenylpropanoic acid derivatives: Dual agonists for human peroxisome proliferator-activated receptor α and δ. Bioorganic and Medicinal Chemistry Letters. 2006 Feb 15;16(4):771-774. https://doi.org/10.1016/j.bmcl.2005.11.029
Kasuga, Jun Ichi ; Hashimoto, Yuichi ; Miyachi, Hiroyuki. / Concise and efficient asymmetric synthesis of (S)-2-ethylphenylpropanoic acid derivatives : Dual agonists for human peroxisome proliferator-activated receptor α and δ. In: Bioorganic and Medicinal Chemistry Letters. 2006 ; Vol. 16, No. 4. pp. 771-774.
@article{c52f60a901874882ab709f5237c8d2dd,
title = "Concise and efficient asymmetric synthesis of (S)-2-ethylphenylpropanoic acid derivatives: Dual agonists for human peroxisome proliferator-activated receptor α and δ",
abstract = "Optically active (S)-2-ethylphenylpropanoic acid derivatives, dual agonists for human peroxisome proliferator-activated receptor (PPAR) α and δ, were efficiently prepared by using Evan's chiral oxazolidinone technique and reductive amide N-alkylation as key steps.",
keywords = "Metabolic syndrome, PPARα, PPARδ, Reductive amide alkylation",
author = "Kasuga, {Jun Ichi} and Yuichi Hashimoto and Hiroyuki Miyachi",
year = "2006",
month = "2",
day = "15",
doi = "10.1016/j.bmcl.2005.11.029",
language = "English",
volume = "16",
pages = "771--774",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "4",

}

TY - JOUR

T1 - Concise and efficient asymmetric synthesis of (S)-2-ethylphenylpropanoic acid derivatives

T2 - Dual agonists for human peroxisome proliferator-activated receptor α and δ

AU - Kasuga, Jun Ichi

AU - Hashimoto, Yuichi

AU - Miyachi, Hiroyuki

PY - 2006/2/15

Y1 - 2006/2/15

N2 - Optically active (S)-2-ethylphenylpropanoic acid derivatives, dual agonists for human peroxisome proliferator-activated receptor (PPAR) α and δ, were efficiently prepared by using Evan's chiral oxazolidinone technique and reductive amide N-alkylation as key steps.

AB - Optically active (S)-2-ethylphenylpropanoic acid derivatives, dual agonists for human peroxisome proliferator-activated receptor (PPAR) α and δ, were efficiently prepared by using Evan's chiral oxazolidinone technique and reductive amide N-alkylation as key steps.

KW - Metabolic syndrome

KW - PPARα

KW - PPARδ

KW - Reductive amide alkylation

UR - http://www.scopus.com/inward/record.url?scp=30344435617&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=30344435617&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2005.11.029

DO - 10.1016/j.bmcl.2005.11.029

M3 - Article

VL - 16

SP - 771

EP - 774

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 4

ER -

Access to Document