Abstract
Optically active (S)-2-ethylphenylpropanoic acid derivatives, dual agonists for human peroxisome proliferator-activated receptor (PPAR) α and δ, were efficiently prepared by using Evan's chiral oxazolidinone technique and reductive amide N-alkylation as key steps.
Original language | English |
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Pages (from-to) | 771-774 |
Number of pages | 4 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 16 |
Issue number | 4 |
DOIs | |
Publication status | Published - Feb 15 2006 |
Keywords
- Metabolic syndrome
- PPARα
- PPARδ
- Reductive amide alkylation
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry