Concise and efficient asymmetric synthesis of (S)-2-ethylphenylpropanoic acid derivatives: Dual agonists for human peroxisome proliferator-activated receptor α and δ

Jun Ichi Kasuga, Yuichi Hashimoto, Hiroyuki Miyachi

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Optically active (S)-2-ethylphenylpropanoic acid derivatives, dual agonists for human peroxisome proliferator-activated receptor (PPAR) α and δ, were efficiently prepared by using Evan's chiral oxazolidinone technique and reductive amide N-alkylation as key steps.

Original languageEnglish
Pages (from-to)771-774
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume16
Issue number4
DOIs
Publication statusPublished - Feb 15 2006
Externally publishedYes

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Keywords

  • Metabolic syndrome
  • PPARα
  • PPARδ
  • Reductive amide alkylation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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