Abstract
Optically active (S)-2-ethylphenylpropanoic acid derivatives, dual agonists for human peroxisome proliferator-activated receptor (PPAR) α and δ, were efficiently prepared by using Evan's chiral oxazolidinone technique and reductive amide N-alkylation as key steps.
| Original language | English |
|---|---|
| Pages (from-to) | 771-774 |
| Number of pages | 4 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 16 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Feb 15 2006 |
Keywords
- Metabolic syndrome
- PPARα
- PPARδ
- Reductive amide alkylation
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry
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Kasuga, J. I., Hashimoto, Y., & Miyachi, H. (2006). Concise and efficient asymmetric synthesis of (S)-2-ethylphenylpropanoic acid derivatives: Dual agonists for human peroxisome proliferator-activated receptor α and δ. Bioorganic and Medicinal Chemistry Letters, 16(4), 771-774. https://doi.org/10.1016/j.bmcl.2005.11.029