Concanamycin B inhibits the expression of newly-synthesized MHC class II molecules on the cell surface

K. Ito, T. Kobayashi, Y. Moriyama, K. Toshima, K. Tatsuta, T. Kakiuchi, M. Futai, H. L. Ploegh, K. Miwa

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We screened natural chemical compounds which inhibit the expression of newly-synthesized MHC class II molecules on the cell surface. IFN-y stimulates Colo 205 adenocarcinoma cells to induce the expression of MHC class II MHC class II, and ICAM-1 molecules on the cell surface. We show here that concanamycin B inhibits the expression of MHC class II molecules on Colo 205 cells, whereas it does not affect the expression of MHC class I and ICAM-1 molecules. Concanamycin B also abrogates the enhancement of the MHC class II expression by IL-4 on mouse lymphocytes. Furthermore, concanamycin B suppresses the antigen presentation by MHC class II molecules.

Original languageEnglish
Pages (from-to)488-494
Number of pages7
JournalJournal of Antibiotics
Volume48
Issue number6
Publication statusPublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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