Concanamycin B inhibits the expression of newly-synthesized MHC class II molecules on the cell surface

K. Ito, T. Kobayashi, Y. Moriyama, K. Toshima, K. Tatsuta, T. Kakiuchi, M. Futai, H. L. Ploegh, K. Miwa

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We screened natural chemical compounds which inhibit the expression of newly-synthesized MHC class II molecules on the cell surface. IFN-y stimulates Colo 205 adenocarcinoma cells to induce the expression of MHC class II MHC class II, and ICAM-1 molecules on the cell surface. We show here that concanamycin B inhibits the expression of MHC class II molecules on Colo 205 cells, whereas it does not affect the expression of MHC class I and ICAM-1 molecules. Concanamycin B also abrogates the enhancement of the MHC class II expression by IL-4 on mouse lymphocytes. Furthermore, concanamycin B suppresses the antigen presentation by MHC class II molecules.

Original languageEnglish
Pages (from-to)488-494
Number of pages7
JournalJournal of Antibiotics
Volume48
Issue number6
Publication statusPublished - 1995
Externally publishedYes

Fingerprint

Intercellular Adhesion Molecule-1
Antigen Presentation
Interleukin-4
Adenocarcinoma
Lymphocytes
concanamycin B

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

Ito, K., Kobayashi, T., Moriyama, Y., Toshima, K., Tatsuta, K., Kakiuchi, T., ... Miwa, K. (1995). Concanamycin B inhibits the expression of newly-synthesized MHC class II molecules on the cell surface. Journal of Antibiotics, 48(6), 488-494.

Concanamycin B inhibits the expression of newly-synthesized MHC class II molecules on the cell surface. / Ito, K.; Kobayashi, T.; Moriyama, Y.; Toshima, K.; Tatsuta, K.; Kakiuchi, T.; Futai, M.; Ploegh, H. L.; Miwa, K.

In: Journal of Antibiotics, Vol. 48, No. 6, 1995, p. 488-494.

Research output: Contribution to journalArticle

Ito, K, Kobayashi, T, Moriyama, Y, Toshima, K, Tatsuta, K, Kakiuchi, T, Futai, M, Ploegh, HL & Miwa, K 1995, 'Concanamycin B inhibits the expression of newly-synthesized MHC class II molecules on the cell surface', Journal of Antibiotics, vol. 48, no. 6, pp. 488-494.
Ito K, Kobayashi T, Moriyama Y, Toshima K, Tatsuta K, Kakiuchi T et al. Concanamycin B inhibits the expression of newly-synthesized MHC class II molecules on the cell surface. Journal of Antibiotics. 1995;48(6):488-494.
Ito, K. ; Kobayashi, T. ; Moriyama, Y. ; Toshima, K. ; Tatsuta, K. ; Kakiuchi, T. ; Futai, M. ; Ploegh, H. L. ; Miwa, K. / Concanamycin B inhibits the expression of newly-synthesized MHC class II molecules on the cell surface. In: Journal of Antibiotics. 1995 ; Vol. 48, No. 6. pp. 488-494.
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