Computed tomography findings of congenital generalized lipodystrophy: Multiple nodular fatty liver and diffuse sclerosis of bones

Takayoshi Shinya, Shuhei Sato, Shiro Akaki, Takeshi Ogata, Katsuya Kato, Atsuhito Tone, Susumu Kanazawa

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Congenital generalized lipodystrophy (CGL) is a rare autosomal recessive disease that is also referred to as Berardinelli-Seip syndrome. It is characterized by a lack of adipose tissue throughout the body from birth, muscular hypertrophy, advanced bone age, fatty liver, and insulin resistance. We describe computed tomography (CT) and magnetic resonance findings for a 35-year-old woman with CGL. Multiple nodular, well-defined regions of fatty infiltration of the liver are rare and have never been previously reported in a patient with lipodystrophy. To our knowledge, this is the first report describing CT findings of bone sclerotic changes associated with CGL.

Original languageEnglish
Pages (from-to)484-487
Number of pages4
JournalRadiation Medicine - Medical Imaging and Radiation Oncology
Volume25
Issue number9
DOIs
Publication statusPublished - Nov 1 2007

Keywords

  • Computed tomography (CT)
  • Congenital generalized lipodystrophy (CGL)
  • Fatty liver
  • Multiple nodular fatty infiltration
  • Sclerosis of bones

ASJC Scopus subject areas

  • Radiation
  • Radiology Nuclear Medicine and imaging
  • Oncology

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