Computed tomography analysis of the association between the SH2B1 rs7498665 single-nucleotide polymorphism and visceral fat area

Kikuko Hotta, Takuya Kitamoto, Aya Kitamoto, Seiho Mizusawa, Tomoaki Matsuo, Yoshio Nakata, Hideyuki Hyogo, Hidenori Ochi, Seika Kamohara, Nobuyuki Miyatake, Kazuaki Kotani, Ryoya Komatsu, Naoto Itoh, Ikuo Mineo, Jun Wada, Masato Yoneda, Atsushi Nakajima, Tohru Funahashi, Shigeru Miyazaki, Katsuto TokunagaHiroaki Masuzaki, Takato Ueno, Kazuaki Chayama, Kazuyuki Hamaguchi, Kentaro Yamada, Toshiaki Hanafusa, Shinichi Oikawa, Hironobu Yoshimatsu, Toshiie Sakata, Kiyoji Tanaka, Yuji Matsuzawa, Kazuwa Nakao, Akihiro Sekine

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Visceral fat accumulation has an important role in increasing morbidity and mortality rate by increasing the risk of developing several metabolic disorders, such as type 2 diabetes, dyslipidemia and hypertension. New genetic loci that contribute to the development of obesity have been identified by genome-wide association studies in Caucasian populations. We genotyped 1279 Japanese subjects (556 men and 723 women), who underwent computed tomography (CT) for measuring visceral fat area (VFA) and subcutaneous fat area (SFA), for the following single-nucleotide polymorphisms (SNPs): NEGR1 rs2815752, SEC16B rs10913469, TMEM18 rs6548238, ETV5 rs7647305, GNPDA2 rs10938397, BDNF rs6265 and rs925946, MTCH2 rs10838738, SH2B1 rs7498665, MAF rs1424233, and KCTD15 rs29941 and rs11084753. In the additive model, none of the SNPs were significantly associated with body mass index (BMI). The SH2B1 rs7498665 risk allele was found to be significantly associated with VFA (P=0.00047) but not with BMI or SFA. When the analysis was performed in men and women separately, no significant associations with VFA were observed (P=0.0099 in men and P=0.022 in women). None of the other SNPs were significantly associated with SFA. Our results suggest that there is a VFA-specific genetic factor and that a polymorphism in the SH2B1 gene influences the risk of visceral fat accumulation.

Original languageEnglish
Pages (from-to)716-719
Number of pages4
JournalJournal of Human Genetics
Volume56
Issue number10
DOIs
Publication statusPublished - Oct 2011

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Intra-Abdominal Fat
Single Nucleotide Polymorphism
Tomography
Subcutaneous Fat
Body Mass Index
Genetic Loci
Genome-Wide Association Study
Brain-Derived Neurotrophic Factor
Dyslipidemias
Type 2 Diabetes Mellitus
Obesity
Alleles
Hypertension
Morbidity
Mortality
Population
Genes

Keywords

  • computed tomography
  • Japanese subjects
  • obesity
  • SH2B1
  • visceral fat area

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Computed tomography analysis of the association between the SH2B1 rs7498665 single-nucleotide polymorphism and visceral fat area. / Hotta, Kikuko; Kitamoto, Takuya; Kitamoto, Aya; Mizusawa, Seiho; Matsuo, Tomoaki; Nakata, Yoshio; Hyogo, Hideyuki; Ochi, Hidenori; Kamohara, Seika; Miyatake, Nobuyuki; Kotani, Kazuaki; Komatsu, Ryoya; Itoh, Naoto; Mineo, Ikuo; Wada, Jun; Yoneda, Masato; Nakajima, Atsushi; Funahashi, Tohru; Miyazaki, Shigeru; Tokunaga, Katsuto; Masuzaki, Hiroaki; Ueno, Takato; Chayama, Kazuaki; Hamaguchi, Kazuyuki; Yamada, Kentaro; Hanafusa, Toshiaki; Oikawa, Shinichi; Yoshimatsu, Hironobu; Sakata, Toshiie; Tanaka, Kiyoji; Matsuzawa, Yuji; Nakao, Kazuwa; Sekine, Akihiro.

In: Journal of Human Genetics, Vol. 56, No. 10, 10.2011, p. 716-719.

Research output: Contribution to journalArticle

Hotta, K, Kitamoto, T, Kitamoto, A, Mizusawa, S, Matsuo, T, Nakata, Y, Hyogo, H, Ochi, H, Kamohara, S, Miyatake, N, Kotani, K, Komatsu, R, Itoh, N, Mineo, I, Wada, J, Yoneda, M, Nakajima, A, Funahashi, T, Miyazaki, S, Tokunaga, K, Masuzaki, H, Ueno, T, Chayama, K, Hamaguchi, K, Yamada, K, Hanafusa, T, Oikawa, S, Yoshimatsu, H, Sakata, T, Tanaka, K, Matsuzawa, Y, Nakao, K & Sekine, A 2011, 'Computed tomography analysis of the association between the SH2B1 rs7498665 single-nucleotide polymorphism and visceral fat area', Journal of Human Genetics, vol. 56, no. 10, pp. 716-719. https://doi.org/10.1038/jhg.2011.86
Hotta, Kikuko ; Kitamoto, Takuya ; Kitamoto, Aya ; Mizusawa, Seiho ; Matsuo, Tomoaki ; Nakata, Yoshio ; Hyogo, Hideyuki ; Ochi, Hidenori ; Kamohara, Seika ; Miyatake, Nobuyuki ; Kotani, Kazuaki ; Komatsu, Ryoya ; Itoh, Naoto ; Mineo, Ikuo ; Wada, Jun ; Yoneda, Masato ; Nakajima, Atsushi ; Funahashi, Tohru ; Miyazaki, Shigeru ; Tokunaga, Katsuto ; Masuzaki, Hiroaki ; Ueno, Takato ; Chayama, Kazuaki ; Hamaguchi, Kazuyuki ; Yamada, Kentaro ; Hanafusa, Toshiaki ; Oikawa, Shinichi ; Yoshimatsu, Hironobu ; Sakata, Toshiie ; Tanaka, Kiyoji ; Matsuzawa, Yuji ; Nakao, Kazuwa ; Sekine, Akihiro. / Computed tomography analysis of the association between the SH2B1 rs7498665 single-nucleotide polymorphism and visceral fat area. In: Journal of Human Genetics. 2011 ; Vol. 56, No. 10. pp. 716-719.
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AU - Mizusawa, Seiho

AU - Matsuo, Tomoaki

AU - Nakata, Yoshio

AU - Hyogo, Hideyuki

AU - Ochi, Hidenori

AU - Kamohara, Seika

AU - Miyatake, Nobuyuki

AU - Kotani, Kazuaki

AU - Komatsu, Ryoya

AU - Itoh, Naoto

AU - Mineo, Ikuo

AU - Wada, Jun

AU - Yoneda, Masato

AU - Nakajima, Atsushi

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AU - Masuzaki, Hiroaki

AU - Ueno, Takato

AU - Chayama, Kazuaki

AU - Hamaguchi, Kazuyuki

AU - Yamada, Kentaro

AU - Hanafusa, Toshiaki

AU - Oikawa, Shinichi

AU - Yoshimatsu, Hironobu

AU - Sakata, Toshiie

AU - Tanaka, Kiyoji

AU - Matsuzawa, Yuji

AU - Nakao, Kazuwa

AU - Sekine, Akihiro

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N2 - Visceral fat accumulation has an important role in increasing morbidity and mortality rate by increasing the risk of developing several metabolic disorders, such as type 2 diabetes, dyslipidemia and hypertension. New genetic loci that contribute to the development of obesity have been identified by genome-wide association studies in Caucasian populations. We genotyped 1279 Japanese subjects (556 men and 723 women), who underwent computed tomography (CT) for measuring visceral fat area (VFA) and subcutaneous fat area (SFA), for the following single-nucleotide polymorphisms (SNPs): NEGR1 rs2815752, SEC16B rs10913469, TMEM18 rs6548238, ETV5 rs7647305, GNPDA2 rs10938397, BDNF rs6265 and rs925946, MTCH2 rs10838738, SH2B1 rs7498665, MAF rs1424233, and KCTD15 rs29941 and rs11084753. In the additive model, none of the SNPs were significantly associated with body mass index (BMI). The SH2B1 rs7498665 risk allele was found to be significantly associated with VFA (P=0.00047) but not with BMI or SFA. When the analysis was performed in men and women separately, no significant associations with VFA were observed (P=0.0099 in men and P=0.022 in women). None of the other SNPs were significantly associated with SFA. Our results suggest that there is a VFA-specific genetic factor and that a polymorphism in the SH2B1 gene influences the risk of visceral fat accumulation.

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