Computed direct magnification radiography of bone tumors

Axel Hillmann, Thomas Mark Link, Toshifumi Ozaki, Thomas Vestring, Winfried Winkelmann

Research output: Contribution to journalArticlepeer-review


The purpose of this study was to assess the diagnostic performance of computed direct magnification radiography in diagnosing bone tumors as compared with conventional radiography. Ninety-one patients with primary bone tumors and tumor-like lesions were radiographed with conventional and magnification techniques. All radiographs were analyzed by one orthopedic surgeon and two radiologists and the findings were correlated with histopathotogy. Two microfocal X-ray units were used for computed direct magnification radiography with a focal spot size of 20-130 μm. Using magnification versus conventional radiography, the diagnosis of benign and malignant lesions as well as the individual tumor diagnosis was obtained with higher accuracy (85% versus 71% and 69% versus 51%, respectively, P < 0.01). Margins of destruction, periosteal reactions, and matrix patterns were evaluated with higher accuracy by all observers (P < 0.01). We conclude that computed direct magnification radiography may improve evaluation and diagnosis of bone tumors.

Original languageEnglish
Pages (from-to)116-122
Number of pages7
JournalJournal of cancer research and clinical oncology
Issue number2
Publication statusPublished - Feb 19 2001
Externally publishedYes


  • Bone neoplasm
  • Bones radiography
  • Computed direct magnification radiography
  • Radiography comparative studies
  • Radiography technology

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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