TY - GEN
T1 - Comprehensive physiological cardiovascular model enables automatic correction of hemodynamics in patients with acute life-threatening heart failure
AU - Uemura, Kazunori
AU - Kamiya, Atsunori
AU - Shimizu, Shuji
AU - Shishido, Toshiaki
AU - Sugimachi, Masaru
AU - Sunagawa, Kenji
PY - 2006/12/1
Y1 - 2006/12/1
N2 - Saving life of patients with acute life-threatening heart failure is a major challenge. One has to correct several fatal hemodynamic abnormalities at the same time within a limited time frame. The formulation of such complicated treatments enables the development of a system that can be used to save automatically lives of patients with acute heart failure, an autopilot system. To accomplish this, we established a comprehensive physiological cardiovascular model, on which we based the design of the autopilot system. By translating hemodynamics into cardiovascular parameters (pumping ability, vascular resistance, blood volume), and by controlling each of these with individual drugs, we were able to correct blood pressure, cardiac output, and left atrial pressure to the target values rapidly (5.2 ± 6.6, 6.8 ± 4.6, and 11.7 ± 9.8 minutes), stably, and simultaneously.
AB - Saving life of patients with acute life-threatening heart failure is a major challenge. One has to correct several fatal hemodynamic abnormalities at the same time within a limited time frame. The formulation of such complicated treatments enables the development of a system that can be used to save automatically lives of patients with acute heart failure, an autopilot system. To accomplish this, we established a comprehensive physiological cardiovascular model, on which we based the design of the autopilot system. By translating hemodynamics into cardiovascular parameters (pumping ability, vascular resistance, blood volume), and by controlling each of these with individual drugs, we were able to correct blood pressure, cardiac output, and left atrial pressure to the target values rapidly (5.2 ± 6.6, 6.8 ± 4.6, and 11.7 ± 9.8 minutes), stably, and simultaneously.
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U2 - 10.1109/IEMBS.2006.259935
DO - 10.1109/IEMBS.2006.259935
M3 - Conference contribution
C2 - 17945972
AN - SCOPUS:34047093984
SN - 1424400325
SN - 9781424400324
T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
SP - 198
EP - 201
BT - 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
T2 - 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
Y2 - 30 August 2006 through 3 September 2006
ER -