Comprehensive analysis of systemically disseminated ST8/non-USA300 type community-acquired methicillin-resistant Staphylococcus aureus infection

Hideharu Hagiya; Junzo Hisatsune; Taro Kojima; Sumiko Shiota; Hiromichi Naito; Shingo Hagioka; Naoki Morimoto; Fumio Otsuka; Motoyuki Sugai

doi:10.2169/internalmedicine.53.1746

Comprehensive analysis of systemically disseminated ST8/non-USA300 type community-acquired methicillin-resistant Staphylococcus aureus infection

Hideharu Hagiya, Junzo Hisatsune, Taro Kojima, Sumiko Shiota, Hiromichi Naito, Shingo Hagioka, Naoki Morimoto, Fumio Otsuka, Motoyuki Sugai

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is genetically heterogeneous and various genotypes are spreading worldwide. We herein report a case of systematically disseminated Japan-intrinsic CA-MRSA infection that was successfully treated. A genetically identical single strain was isolated from a total of 11 different parts of the patient's body, and the pathogen was found to be multilocus sequence type 8, staphylococcal cassette chromosome mec IV, coagulase type III and negative for both Panton-Valentine leukocidin and arginine catabolic mobile element. The epidemiology and pathogenicity of the Japan-intrinsic CA-MRSA strain remain unknown, and further investigation of this life-threatening organism is warranted.

Original language	English
Pages (from-to)	907-912
Number of pages	6
Journal	Internal Medicine
Volume	53
Issue number	8
DOIs	https://doi.org/10.2169/internalmedicine.53.1746
Publication status	Published - 2014

Keywords

Community-acquired methicillin-resistant staphylococcus aureus
Multilocus sequence type 8
Sepsis
Toxic shock syndrome
USA300

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.53.1746

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title = "Comprehensive analysis of systemically disseminated ST8/non-USA300 type community-acquired methicillin-resistant Staphylococcus aureus infection",

abstract = "Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is genetically heterogeneous and various genotypes are spreading worldwide. We herein report a case of systematically disseminated Japan-intrinsic CA-MRSA infection that was successfully treated. A genetically identical single strain was isolated from a total of 11 different parts of the patient's body, and the pathogen was found to be multilocus sequence type 8, staphylococcal cassette chromosome mec IV, coagulase type III and negative for both Panton-Valentine leukocidin and arginine catabolic mobile element. The epidemiology and pathogenicity of the Japan-intrinsic CA-MRSA strain remain unknown, and further investigation of this life-threatening organism is warranted.",

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AU - Hagiya, Hideharu

AU - Hisatsune, Junzo

AU - Kojima, Taro

AU - Shiota, Sumiko

AU - Naito, Hiromichi

AU - Hagioka, Shingo

AU - Morimoto, Naoki

AU - Otsuka, Fumio

AU - Sugai, Motoyuki

PY - 2014

Y1 - 2014

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AB - Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is genetically heterogeneous and various genotypes are spreading worldwide. We herein report a case of systematically disseminated Japan-intrinsic CA-MRSA infection that was successfully treated. A genetically identical single strain was isolated from a total of 11 different parts of the patient's body, and the pathogen was found to be multilocus sequence type 8, staphylococcal cassette chromosome mec IV, coagulase type III and negative for both Panton-Valentine leukocidin and arginine catabolic mobile element. The epidemiology and pathogenicity of the Japan-intrinsic CA-MRSA strain remain unknown, and further investigation of this life-threatening organism is warranted.

KW - Community-acquired methicillin-resistant staphylococcus aureus

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KW - Sepsis

KW - Toxic shock syndrome

KW - USA300

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Comprehensive analysis of systemically disseminated ST8/non-USA300 type community-acquired methicillin-resistant Staphylococcus aureus infection

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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