Composite paraganglioma-ganglioneuroma in the retroperitoneum

Shoji Hirasaki, Hiromitsu Kanzaki, Masato Okuda, Seiyuu Suzuki, Tetsuji Fukuhara, Toshihito Hanaoka

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Paragangliomas occur most commonly in head and neck region and much less frequently, they are found in the retroperitoneum. Composite paraganglioma-ganglioneuroma of the retroperitoneum is very rare. Case presentation: We present an unusual case of retroperitoneal composite paraganglioma-ganglioneuroma discovered on computed tomography in a 63-year-old female patient. Routine hematological examination and biochemical tests were within normal limits. Plasma adrenaline was 0.042 ng/ml, plasma noradrenaline 0.341 ng/ml, and plasma dopamine 131I-Metaiodobenzylguanidine (131I-MIBG) 48 hours after radioisotope injection. Under the diagnosis of paraganglioma in the retroperitoneum, the patient underwent surgery. The resected tumor (6.5 × 5 × 3 cm) was solid and easily removed en bloc. The cut surface of the tumor and histology revealed two different components in the tumor: paraganglioma centrally and ganglioneuroma on the periphery. She remains disease-free 18 months after surgery. Conclusion: This case reminds us that neuroendocrine tumor should be included in the differential diagnosis of a retroperitoneal mass although composite paraganglioma-ganglioneuroma in the retroperitoneum is very rare.

Original languageEnglish
Article number1477
Pages (from-to)81
Number of pages1
JournalWorld Journal of Surgical Oncology
Volume7
DOIs
Publication statusPublished - Nov 5 2009
Externally publishedYes

Fingerprint

Ganglioneuroma
Paraganglioma
Neoplasms
Neuroendocrine Tumors
Radioisotopes
Epinephrine
Dopamine
Histology
Norepinephrine
Differential Diagnosis
Neck
Head
Tomography
Injections

ASJC Scopus subject areas

  • Oncology
  • Surgery

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Composite paraganglioma-ganglioneuroma in the retroperitoneum. / Hirasaki, Shoji; Kanzaki, Hiromitsu; Okuda, Masato; Suzuki, Seiyuu; Fukuhara, Tetsuji; Hanaoka, Toshihito.

In: World Journal of Surgical Oncology, Vol. 7, 1477, 05.11.2009, p. 81.

Research output: Contribution to journalArticle

Hirasaki, Shoji ; Kanzaki, Hiromitsu ; Okuda, Masato ; Suzuki, Seiyuu ; Fukuhara, Tetsuji ; Hanaoka, Toshihito. / Composite paraganglioma-ganglioneuroma in the retroperitoneum. In: World Journal of Surgical Oncology. 2009 ; Vol. 7. pp. 81.
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