Components of foods inhibit a drug exporter, human multidrug and toxin extrusion transporter 1

Tatsuya Kawasaki; Hideyuki Ito; Hiroshi Omote

doi:10.1248/bpb.b13-00815

Components of foods inhibit a drug exporter, human multidrug and toxin extrusion transporter 1

Tatsuya Kawasaki, Hideyuki Ito, Hiroshi Omote

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Human multidrug and toxic compounds extrusion transporter 1 (hMATE1/SLC47A1 ) is a H⁺ -coupled organic cation exporter responsible for the final step of excretion of various xenobiotics at the kidney and liver. In this study, effects of dietary constituents on hMATE1 mediated drug transport were examined to evaluate possible food-drug interactions. Bergamottin inhibited hMATE1 mediated tetraethyl ammonium transport activity, with a K_i of 98.7 μM . Coumarins, flavonols, and catechin inhibited hMATE1 activity. Among 23 compounds tested, isorhamnetin was the strongest inhibitor of hMATE1 with the K_i of 0.32 μM in a competitive manner. Since isorhamnetin is abundant in Ginkgo biloba that is widely used for herbal supplements, the findings suggest the potential hMATE1 related food-drug interactions.

Original language	English
Pages (from-to)	292-297
Number of pages	6
Journal	Biological and Pharmaceutical Bulletin
Volume	37
Issue number	2
DOIs	https://doi.org/10.1248/bpb.b13-00815
Publication status	Published - Feb 2014
Externally published	Yes

Keywords

Food-drug interaction
Ginkgo biloba
Isorhamnetin
Multidrug and toxic compounds extrusion
Multidrug and toxin extrusion (mate)

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

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title = "Components of foods inhibit a drug exporter, human multidrug and toxin extrusion transporter 1",

abstract = "Human multidrug and toxic compounds extrusion transporter 1 (hMATE1/SLC47A1 ) is a H+ -coupled organic cation exporter responsible for the final step of excretion of various xenobiotics at the kidney and liver. In this study, effects of dietary constituents on hMATE1 mediated drug transport were examined to evaluate possible food-drug interactions. Bergamottin inhibited hMATE1 mediated tetraethyl ammonium transport activity, with a Ki of 98.7 μM . Coumarins, flavonols, and catechin inhibited hMATE1 activity. Among 23 compounds tested, isorhamnetin was the strongest inhibitor of hMATE1 with the Ki of 0.32 μM in a competitive manner. Since isorhamnetin is abundant in Ginkgo biloba that is widely used for herbal supplements, the findings suggest the potential hMATE1 related food-drug interactions.",

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author = "Tatsuya Kawasaki and Hideyuki Ito and Hiroshi Omote",

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AU - Kawasaki, Tatsuya

AU - Ito, Hideyuki

AU - Omote, Hiroshi

PY - 2014/2

Y1 - 2014/2

N2 - Human multidrug and toxic compounds extrusion transporter 1 (hMATE1/SLC47A1 ) is a H+ -coupled organic cation exporter responsible for the final step of excretion of various xenobiotics at the kidney and liver. In this study, effects of dietary constituents on hMATE1 mediated drug transport were examined to evaluate possible food-drug interactions. Bergamottin inhibited hMATE1 mediated tetraethyl ammonium transport activity, with a Ki of 98.7 μM . Coumarins, flavonols, and catechin inhibited hMATE1 activity. Among 23 compounds tested, isorhamnetin was the strongest inhibitor of hMATE1 with the Ki of 0.32 μM in a competitive manner. Since isorhamnetin is abundant in Ginkgo biloba that is widely used for herbal supplements, the findings suggest the potential hMATE1 related food-drug interactions.

AB - Human multidrug and toxic compounds extrusion transporter 1 (hMATE1/SLC47A1 ) is a H+ -coupled organic cation exporter responsible for the final step of excretion of various xenobiotics at the kidney and liver. In this study, effects of dietary constituents on hMATE1 mediated drug transport were examined to evaluate possible food-drug interactions. Bergamottin inhibited hMATE1 mediated tetraethyl ammonium transport activity, with a Ki of 98.7 μM . Coumarins, flavonols, and catechin inhibited hMATE1 activity. Among 23 compounds tested, isorhamnetin was the strongest inhibitor of hMATE1 with the Ki of 0.32 μM in a competitive manner. Since isorhamnetin is abundant in Ginkgo biloba that is widely used for herbal supplements, the findings suggest the potential hMATE1 related food-drug interactions.

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KW - Ginkgo biloba

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KW - Multidrug and toxic compounds extrusion

KW - Multidrug and toxin extrusion (mate)

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ER -

Components of foods inhibit a drug exporter, human multidrug and toxin extrusion transporter 1

Abstract

Keywords

ASJC Scopus subject areas

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