Abstract
Human multidrug and toxic compounds extrusion transporter 1 (hMATE1/SLC47A1 ) is a H+ -coupled organic cation exporter responsible for the final step of excretion of various xenobiotics at the kidney and liver. In this study, effects of dietary constituents on hMATE1 mediated drug transport were examined to evaluate possible food-drug interactions. Bergamottin inhibited hMATE1 mediated tetraethyl ammonium transport activity, with a Ki of 98.7 μM . Coumarins, flavonols, and catechin inhibited hMATE1 activity. Among 23 compounds tested, isorhamnetin was the strongest inhibitor of hMATE1 with the Ki of 0.32 μM in a competitive manner. Since isorhamnetin is abundant in Ginkgo biloba that is widely used for herbal supplements, the findings suggest the potential hMATE1 related food-drug interactions.
| Original language | English |
|---|---|
| Pages (from-to) | 292-297 |
| Number of pages | 6 |
| Journal | Biological and Pharmaceutical Bulletin |
| Volume | 37 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2014 |
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Keywords
- Food-drug interaction
- Ginkgo biloba
- Isorhamnetin
- Multidrug and toxic compounds extrusion
- Multidrug and toxin extrusion (mate)
ASJC Scopus subject areas
- Pharmaceutical Science
- Pharmacology
Cite this
Components of foods inhibit a drug exporter, human multidrug and toxin extrusion transporter 1. / Kawasaki, Tatsuya; Ito, Hideyuki; Omote, Hiroshi.
In: Biological and Pharmaceutical Bulletin, Vol. 37, No. 2, 02.2014, p. 292-297.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Components of foods inhibit a drug exporter, human multidrug and toxin extrusion transporter 1
AU - Kawasaki, Tatsuya
AU - Ito, Hideyuki
AU - Omote, Hiroshi
PY - 2014/2
Y1 - 2014/2
N2 - Human multidrug and toxic compounds extrusion transporter 1 (hMATE1/SLC47A1 ) is a H+ -coupled organic cation exporter responsible for the final step of excretion of various xenobiotics at the kidney and liver. In this study, effects of dietary constituents on hMATE1 mediated drug transport were examined to evaluate possible food-drug interactions. Bergamottin inhibited hMATE1 mediated tetraethyl ammonium transport activity, with a Ki of 98.7 μM . Coumarins, flavonols, and catechin inhibited hMATE1 activity. Among 23 compounds tested, isorhamnetin was the strongest inhibitor of hMATE1 with the Ki of 0.32 μM in a competitive manner. Since isorhamnetin is abundant in Ginkgo biloba that is widely used for herbal supplements, the findings suggest the potential hMATE1 related food-drug interactions.
AB - Human multidrug and toxic compounds extrusion transporter 1 (hMATE1/SLC47A1 ) is a H+ -coupled organic cation exporter responsible for the final step of excretion of various xenobiotics at the kidney and liver. In this study, effects of dietary constituents on hMATE1 mediated drug transport were examined to evaluate possible food-drug interactions. Bergamottin inhibited hMATE1 mediated tetraethyl ammonium transport activity, with a Ki of 98.7 μM . Coumarins, flavonols, and catechin inhibited hMATE1 activity. Among 23 compounds tested, isorhamnetin was the strongest inhibitor of hMATE1 with the Ki of 0.32 μM in a competitive manner. Since isorhamnetin is abundant in Ginkgo biloba that is widely used for herbal supplements, the findings suggest the potential hMATE1 related food-drug interactions.
KW - Food-drug interaction
KW - Ginkgo biloba
KW - Isorhamnetin
KW - Multidrug and toxic compounds extrusion
KW - Multidrug and toxin extrusion (mate)
UR - http://www.scopus.com/inward/record.url?scp=84893230537&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84893230537&partnerID=8YFLogxK
U2 - 10.1248/bpb.b13-00815
DO - 10.1248/bpb.b13-00815
M3 - Article
C2 - 24492725
AN - SCOPUS:84893230537
VL - 37
SP - 292
EP - 297
JO - Biological and Pharmaceutical Bulletin
JF - Biological and Pharmaceutical Bulletin
SN - 0918-6158
IS - 2
ER -