Components of foods inhibit a drug exporter, human multidrug and toxin extrusion transporter 1

Tatsuya Kawasaki, Hideyuki Ito, Hiroshi Omote

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Human multidrug and toxic compounds extrusion transporter 1 (hMATE1/SLC47A1 ) is a H+ -coupled organic cation exporter responsible for the final step of excretion of various xenobiotics at the kidney and liver. In this study, effects of dietary constituents on hMATE1 mediated drug transport were examined to evaluate possible food-drug interactions. Bergamottin inhibited hMATE1 mediated tetraethyl ammonium transport activity, with a Ki of 98.7 μM . Coumarins, flavonols, and catechin inhibited hMATE1 activity. Among 23 compounds tested, isorhamnetin was the strongest inhibitor of hMATE1 with the Ki of 0.32 μM in a competitive manner. Since isorhamnetin is abundant in Ginkgo biloba that is widely used for herbal supplements, the findings suggest the potential hMATE1 related food-drug interactions.

Original languageEnglish
Pages (from-to)292-297
Number of pages6
JournalBiological and Pharmaceutical Bulletin
Volume37
Issue number2
DOIs
Publication statusPublished - Feb 2014

Keywords

  • Food-drug interaction
  • Ginkgo biloba
  • Isorhamnetin
  • Multidrug and toxic compounds extrusion
  • Multidrug and toxin extrusion (mate)

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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