Component analysis of HPLC profiles of unique lipoprotein subclass cholesterols for detection of coronary artery disease

Mitsuyo Okazaki, Shinichi Usui, Akio Fukui, Isao Kubota, Hitonobu Tomoike

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Background: Patients with coronary artery disease (CAD) are known to have several lipoprotein abnormalities. We examined plasma cholesterol concentrations of major lipoproteins and their subclasses, using a gel permeation HPLC, to establish an association between a lipoprotein subclass pattern and the presence of CAD. Methods: We performed a simple and fully automated HPLC, followed by mathematical treatment on chromatograms, for measuring cholesterol concentrations of major lipoproteins and their subclasses in 62 male patients (45 with CAD and 17 controls without CAD) who underwent cardiac catheterization. Results: For major lipoprotein classes, the patient group had a significantly (P

Original languageEnglish
Pages (from-to)2049-2053
Number of pages5
JournalClinical Chemistry
Volume52
Issue number11
DOIs
Publication statusPublished - Nov 2006

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Lipoproteins
Coronary Artery Disease
High Pressure Liquid Chromatography
Cholesterol
Cardiac Catheterization
Permeation
Gels
lipoprotein cholesterol
Association reactions
Plasmas
Therapeutics

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Component analysis of HPLC profiles of unique lipoprotein subclass cholesterols for detection of coronary artery disease. / Okazaki, Mitsuyo; Usui, Shinichi; Fukui, Akio; Kubota, Isao; Tomoike, Hitonobu.

In: Clinical Chemistry, Vol. 52, No. 11, 11.2006, p. 2049-2053.

Research output: Contribution to journalArticle

Okazaki, Mitsuyo ; Usui, Shinichi ; Fukui, Akio ; Kubota, Isao ; Tomoike, Hitonobu. / Component analysis of HPLC profiles of unique lipoprotein subclass cholesterols for detection of coronary artery disease. In: Clinical Chemistry. 2006 ; Vol. 52, No. 11. pp. 2049-2053.
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