Complications of radiofrequency ablation for hepatocellular carcinoma in a multicenter study: An analysis of 16346 treated nodules in 13283 patients

Masahiko Koda, Yoshikazu Murawaki, Yasuaki Hirooka, Mikiya Kitamoto, Masafumi Ono, Hiroshi Sakaeda, Kouji Joko, Shuichi Sato, Katsuyoshi Tamaki, Takahiro Yamasaki, Hiroshi Shibata, Toshinari Shimoe, Tadakazu Matsuda, Nobuyuki Toshikuni, Shin Ichi Fujioka, Kenji Ohmoto, Shinichiro Nakamura, Kazuya Kariyama, Hiroshi Aikata, Yoshiyuki KobayashiAkemi Tsutsui

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Aim: We surveyed multiple centers to identify types and frequency of complications and mortality rate associated with radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC). Methods: We distributed a questionnaire developed by members of the Chugoku-Shikoku Society for the Local Ablation Therapy of Hepatocellular Carcinoma to 20 centers and analyzed types and frequency of complications and mortality rate. Results: In total, 16346 nodules were treated in 13283 patients between January 1999 and November 2010. Five patients (0.038%) died: two from intraperitoneal hemorrhage, and one each from hemothorax, severe acute pancreatitis and perforation of the colon. In 16346 treated nodules, 579 complications (3.54%) were observed, including 78 hemorrhages (0.477%), 276 hepatic injuries (1.69%), 113 extrahepatic organ injuries (0.691%) and 27 tumor progressions (0.17%). The centers that treated a large number of nodules and performed RFA modifications, such as use of artificial ascites, artificial pleural effusion and bile duct cooling, had low complication rates. Conclusion: This study confirmed that RFA is a low-risk treatment for HCC and that sufficient experience and technical skill can reduce complications.

Original languageEnglish
Pages (from-to)1058-1064
Number of pages7
JournalHepatology Research
Volume42
Issue number11
DOIs
Publication statusPublished - Nov 1 2012

    Fingerprint

Keywords

  • Complication
  • Hepatocellular carcinoma
  • Mortality rate
  • Radiofrequency ablation

ASJC Scopus subject areas

  • Hepatology
  • Infectious Diseases

Cite this

Koda, M., Murawaki, Y., Hirooka, Y., Kitamoto, M., Ono, M., Sakaeda, H., Joko, K., Sato, S., Tamaki, K., Yamasaki, T., Shibata, H., Shimoe, T., Matsuda, T., Toshikuni, N., Fujioka, S. I., Ohmoto, K., Nakamura, S., Kariyama, K., Aikata, H., ... Tsutsui, A. (2012). Complications of radiofrequency ablation for hepatocellular carcinoma in a multicenter study: An analysis of 16346 treated nodules in 13283 patients. Hepatology Research, 42(11), 1058-1064. https://doi.org/10.1111/j.1872-034X.2012.01025.x