Complementary roles of pro-gastrin-releasing peptide (ProGRP) and neuron specific enolase (NSE) in diagnosis and prognosis of small-cell lung cancer (SCLC)

Takuo Shibayama, Hiroshi Ueoka, Kenji Nishii, Katsuyuki Kiura, Masahiro Tabata, Kazuyo Miyatake, Takuji Kitajima, Mine Harada

Research output: Contribution to journalArticle

127 Citations (Scopus)

Abstract

In this study, we evaluated the clinical usefulness of ProGRP and NSE for diagnosis and prognosis of small-cell lung cancer (SCLC). Serum levels of ProGRP and NSE were determined in 108 healthy subjects, 103 patients with benign pulmonary diseases, 142 with non-small cell lung cancer (NSCLC), and 114 with SCLC. Sensitivity of ProGRP in diagnosis of SCLC was significantly higher than that of NSE (64.9 vs. 43.0%, P

Original languageEnglish
Pages (from-to)61-69
Number of pages9
JournalLung Cancer
Volume32
Issue number1
DOIs
Publication statusPublished - 2001

Fingerprint

Gastrin-Releasing Peptide
Phosphopyruvate Hydratase
Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
Lung Diseases
Healthy Volunteers
Serum
big gastrin

Keywords

  • Diagnosis
  • Neuron specific enolase (NSE)
  • Pro-gastrin-releasing peptide (ProGRP)
  • Prognostic factor
  • Small-cell lung cancer

ASJC Scopus subject areas

  • Oncology

Cite this

Complementary roles of pro-gastrin-releasing peptide (ProGRP) and neuron specific enolase (NSE) in diagnosis and prognosis of small-cell lung cancer (SCLC). / Shibayama, Takuo; Ueoka, Hiroshi; Nishii, Kenji; Kiura, Katsuyuki; Tabata, Masahiro; Miyatake, Kazuyo; Kitajima, Takuji; Harada, Mine.

In: Lung Cancer, Vol. 32, No. 1, 2001, p. 61-69.

Research output: Contribution to journalArticle

Shibayama, Takuo ; Ueoka, Hiroshi ; Nishii, Kenji ; Kiura, Katsuyuki ; Tabata, Masahiro ; Miyatake, Kazuyo ; Kitajima, Takuji ; Harada, Mine. / Complementary roles of pro-gastrin-releasing peptide (ProGRP) and neuron specific enolase (NSE) in diagnosis and prognosis of small-cell lung cancer (SCLC). In: Lung Cancer. 2001 ; Vol. 32, No. 1. pp. 61-69.
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