Complementary roles of pro-gastrin-releasing peptide (ProGRP) and neuron specific enolase (NSE) in diagnosis and prognosis of small-cell lung cancer (SCLC)

Takuo Shibayama, Hiroshi Ueoka, Kenji Nishii, Katsuyuki Kiura, Masahiro Tabata, Kazuyo Miyatake, Takuji Kitajima, Mine Harada

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129 Citations (Scopus)


In this study, we evaluated the clinical usefulness of ProGRP and NSE for diagnosis and prognosis of small-cell lung cancer (SCLC). Serum levels of ProGRP and NSE were determined in 108 healthy subjects, 103 patients with benign pulmonary diseases, 142 with non-small cell lung cancer (NSCLC), and 114 with SCLC. Sensitivity of ProGRP in diagnosis of SCLC was significantly higher than that of NSE (64.9 vs. 43.0%, P

Original languageEnglish
Pages (from-to)61-69
Number of pages9
JournalLung Cancer
Issue number1
Publication statusPublished - 2001



  • Diagnosis
  • Neuron specific enolase (NSE)
  • Pro-gastrin-releasing peptide (ProGRP)
  • Prognostic factor
  • Small-cell lung cancer

ASJC Scopus subject areas

  • Oncology

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