Complement Proteins and Macrophages: III. The Production of Factor B by Particle‐Ingesting Macrophages

Akio Miyama, Yasuko Kawamoto, Hidetaka Ighikawa, Takeshi Moriyama, Keinosuke Okamoto, Tetsuomi Takahashi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A kinetic study of factor B secretion by particle‐ingesting macrophages showed that the ingestion of zymosan but not latex lead to an early suppression of factor B secretion followed by a significant enhancement. This dual response was proportional to the number of ingested zymosans. After a suppressive period of 24–48 hr, the ingested zymosan stimulated the synthesis of factor B. The response of acid phosphatase synthesis to ingested zymosan was the same as that of factor B, while the synthesis of lactic dehydrogenase proceeded without an early suppression. These results suggest that factor B should be considered an enzyme released into the lysosomes of macrophages.

Original languageEnglish
Pages (from-to)195-203
Number of pages9
JournalMICROBIOLOGY and IMMUNOLOGY
Volume25
Issue number2
DOIs
Publication statusPublished - Feb 1981
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology

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