Competitive Trapping of Nitric Oxide (NO) Between Fe(III)-dithiocarbamate Complex and Liposome-encapsulated Trimethylammonio-PTIO

Effects of Ligand Structure, Charge on Liposome Surface, and External Pressure on NO-trapping Rates

Yoshimi Sueishi, Shinpei Iwamoto

Research output: Contribution to journalArticle

Abstract

Using a competitive nitric oxide (NO)-trapping method between Fe-dithiocarbamate (DTC) complexes and liposome-encapsulated 2-[4-trimethylammonio]-4,4,5,5-tetramethyl-imidazoline-1-oxyl 3-oxide (TMAPTIO), NO-trapping rates of Fe-DTC complexes in the presence of phosphatidylcholine liposomes were quantified for five kinds of Fe-DTC complexes. We investigated how the DTC ligand structure influences the NO-trapping rates of Fe-DTC complexes. The negatively charged liposomes give a higher NO-trapping rate of Fe-DTC complexes than do the positively charged ones, suggesting that the presence of a charge on the liposome surface affects the NO-trapping rate processes of Fe-DTC complexes. In addition, on the basis of the pressure dependence experiments for the competitive reaction, we evaluated the difference in activation volumes between the NO-trapping reactions by Fe-DTC complexes and TMA-PTIO, which allowed us to consider possible reaction mechanisms for the NO-trapping processes.

Original languageEnglish
Pages (from-to)261-272
Number of pages12
JournalApplied Magnetic Resonance
Volume39
Issue number3
DOIs
Publication statusPublished - 2010

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nitric oxide
trapping
ligands
pressure dependence
activation
oxides

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

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title = "Competitive Trapping of Nitric Oxide (NO) Between Fe(III)-dithiocarbamate Complex and Liposome-encapsulated Trimethylammonio-PTIO: Effects of Ligand Structure, Charge on Liposome Surface, and External Pressure on NO-trapping Rates",
abstract = "Using a competitive nitric oxide (NO)-trapping method between Fe-dithiocarbamate (DTC) complexes and liposome-encapsulated 2-[4-trimethylammonio]-4,4,5,5-tetramethyl-imidazoline-1-oxyl 3-oxide (TMAPTIO), NO-trapping rates of Fe-DTC complexes in the presence of phosphatidylcholine liposomes were quantified for five kinds of Fe-DTC complexes. We investigated how the DTC ligand structure influences the NO-trapping rates of Fe-DTC complexes. The negatively charged liposomes give a higher NO-trapping rate of Fe-DTC complexes than do the positively charged ones, suggesting that the presence of a charge on the liposome surface affects the NO-trapping rate processes of Fe-DTC complexes. In addition, on the basis of the pressure dependence experiments for the competitive reaction, we evaluated the difference in activation volumes between the NO-trapping reactions by Fe-DTC complexes and TMA-PTIO, which allowed us to consider possible reaction mechanisms for the NO-trapping processes.",
author = "Yoshimi Sueishi and Shinpei Iwamoto",
year = "2010",
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language = "English",
volume = "39",
pages = "261--272",
journal = "Applied Magnetic Resonance",
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publisher = "Springer Wien",
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T2 - Effects of Ligand Structure, Charge on Liposome Surface, and External Pressure on NO-trapping Rates

AU - Sueishi, Yoshimi

AU - Iwamoto, Shinpei

PY - 2010

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N2 - Using a competitive nitric oxide (NO)-trapping method between Fe-dithiocarbamate (DTC) complexes and liposome-encapsulated 2-[4-trimethylammonio]-4,4,5,5-tetramethyl-imidazoline-1-oxyl 3-oxide (TMAPTIO), NO-trapping rates of Fe-DTC complexes in the presence of phosphatidylcholine liposomes were quantified for five kinds of Fe-DTC complexes. We investigated how the DTC ligand structure influences the NO-trapping rates of Fe-DTC complexes. The negatively charged liposomes give a higher NO-trapping rate of Fe-DTC complexes than do the positively charged ones, suggesting that the presence of a charge on the liposome surface affects the NO-trapping rate processes of Fe-DTC complexes. In addition, on the basis of the pressure dependence experiments for the competitive reaction, we evaluated the difference in activation volumes between the NO-trapping reactions by Fe-DTC complexes and TMA-PTIO, which allowed us to consider possible reaction mechanisms for the NO-trapping processes.

AB - Using a competitive nitric oxide (NO)-trapping method between Fe-dithiocarbamate (DTC) complexes and liposome-encapsulated 2-[4-trimethylammonio]-4,4,5,5-tetramethyl-imidazoline-1-oxyl 3-oxide (TMAPTIO), NO-trapping rates of Fe-DTC complexes in the presence of phosphatidylcholine liposomes were quantified for five kinds of Fe-DTC complexes. We investigated how the DTC ligand structure influences the NO-trapping rates of Fe-DTC complexes. The negatively charged liposomes give a higher NO-trapping rate of Fe-DTC complexes than do the positively charged ones, suggesting that the presence of a charge on the liposome surface affects the NO-trapping rate processes of Fe-DTC complexes. In addition, on the basis of the pressure dependence experiments for the competitive reaction, we evaluated the difference in activation volumes between the NO-trapping reactions by Fe-DTC complexes and TMA-PTIO, which allowed us to consider possible reaction mechanisms for the NO-trapping processes.

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