Comparison of tumor markers in patients with squamous cell carcinoma of the head and neck

Teruhiro Ogawa; Yuuichi Tsurusako; Nobuhiko Kimura; Shinji Nishioka; Hirofumi Akagi; Kazunori Nishizaki; Keiko Nishioka; John Rutka

Comparison of tumor markers in patients with squamous cell carcinoma of the head and neck

Teruhiro Ogawa, Yuuichi Tsurusako, Nobuhiko Kimura, Shinji Nishioka, Hirofumi Akagi, Kazunori Nishizaki, Keiko Nishioka, John Rutka

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

The serum concentrations of three separate tumor markers, squamous cell carcinoma antigen (SCC Ag), carcinoembryonic antigen (CEA) and Cyfra 21-1 were clinically correlated in 86 randomly selected patients with squamous cell carcinoma involving the head and neck. Positive findings for each tumor marker were totalled and statistically analysed. The upper limits of normal for SCC Ag, CEA and Cyfra 21-1 were set at 1.5, 2.5 and 2.0 ng/ml, respectively. Positivity rates were 20.6% for SCC Ag, 14.0% for CEA and 41.7% for Cyfra 21-1. Elevated Cyfra 21-1 concentrations correlated somewhat with age, whereas elevated CEA levels correlated with the site of tumor involvement. Overall, Cyfra 21-1 appeared to be the most useful marker in head and neck squamous cell carcinoma.

Original language	English
Pages (from-to)	72-76
Number of pages	5
Journal	Acta Oto-Laryngologica, Supplement
Issue number	540
Publication status	Published - Jul 28 1999

Keywords

Carcinoembryonic antigen
Cyfra 21-1
Squamous cell carcinoma antigen

ASJC Scopus subject areas

Otorhinolaryngology

Cite this

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title = "Comparison of tumor markers in patients with squamous cell carcinoma of the head and neck",

abstract = "The serum concentrations of three separate tumor markers, squamous cell carcinoma antigen (SCC Ag), carcinoembryonic antigen (CEA) and Cyfra 21-1 were clinically correlated in 86 randomly selected patients with squamous cell carcinoma involving the head and neck. Positive findings for each tumor marker were totalled and statistically analysed. The upper limits of normal for SCC Ag, CEA and Cyfra 21-1 were set at 1.5, 2.5 and 2.0 ng/ml, respectively. Positivity rates were 20.6% for SCC Ag, 14.0% for CEA and 41.7% for Cyfra 21-1. Elevated Cyfra 21-1 concentrations correlated somewhat with age, whereas elevated CEA levels correlated with the site of tumor involvement. Overall, Cyfra 21-1 appeared to be the most useful marker in head and neck squamous cell carcinoma.",

keywords = "Carcinoembryonic antigen, Cyfra 21-1, Squamous cell carcinoma antigen",

author = "Teruhiro Ogawa and Yuuichi Tsurusako and Nobuhiko Kimura and Shinji Nishioka and Hirofumi Akagi and Kazunori Nishizaki and Keiko Nishioka and John Rutka",

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T1 - Comparison of tumor markers in patients with squamous cell carcinoma of the head and neck

AU - Ogawa, Teruhiro

AU - Tsurusako, Yuuichi

AU - Kimura, Nobuhiko

AU - Nishioka, Shinji

AU - Akagi, Hirofumi

AU - Nishizaki, Kazunori

AU - Nishioka, Keiko

AU - Rutka, John

PY - 1999/7/28

Y1 - 1999/7/28

N2 - The serum concentrations of three separate tumor markers, squamous cell carcinoma antigen (SCC Ag), carcinoembryonic antigen (CEA) and Cyfra 21-1 were clinically correlated in 86 randomly selected patients with squamous cell carcinoma involving the head and neck. Positive findings for each tumor marker were totalled and statistically analysed. The upper limits of normal for SCC Ag, CEA and Cyfra 21-1 were set at 1.5, 2.5 and 2.0 ng/ml, respectively. Positivity rates were 20.6% for SCC Ag, 14.0% for CEA and 41.7% for Cyfra 21-1. Elevated Cyfra 21-1 concentrations correlated somewhat with age, whereas elevated CEA levels correlated with the site of tumor involvement. Overall, Cyfra 21-1 appeared to be the most useful marker in head and neck squamous cell carcinoma.

AB - The serum concentrations of three separate tumor markers, squamous cell carcinoma antigen (SCC Ag), carcinoembryonic antigen (CEA) and Cyfra 21-1 were clinically correlated in 86 randomly selected patients with squamous cell carcinoma involving the head and neck. Positive findings for each tumor marker were totalled and statistically analysed. The upper limits of normal for SCC Ag, CEA and Cyfra 21-1 were set at 1.5, 2.5 and 2.0 ng/ml, respectively. Positivity rates were 20.6% for SCC Ag, 14.0% for CEA and 41.7% for Cyfra 21-1. Elevated Cyfra 21-1 concentrations correlated somewhat with age, whereas elevated CEA levels correlated with the site of tumor involvement. Overall, Cyfra 21-1 appeared to be the most useful marker in head and neck squamous cell carcinoma.

KW - Carcinoembryonic antigen

KW - Cyfra 21-1

KW - Squamous cell carcinoma antigen

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M3 - Article

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AN - SCOPUS:0032588133

SN - 0365-5237

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JO - Acta Oto-Laryngologica, Supplement

JF - Acta Oto-Laryngologica, Supplement

IS - 540

ER -

Comparison of tumor markers in patients with squamous cell carcinoma of the head and neck

Abstract

Keywords

ASJC Scopus subject areas

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