Comparison of the concentrations of polychlorinated dibenzo-p-dioxins, dibenzofurans, and dioxin-like polychlorinated biphenyls in maternal and fetal blood, amniotic and allantoic fluids in cattle

Makoto Hirako, Mari Aoki, Koji Kimura, Yasuko Hanafusa, Hiroshi Ishizaki, Yoshihiro Kariya

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

To characterize the maternal-fetal transport of lipophilic endocrine disrupting chemicals, concentrations of polychlorinated (2,3,7,8-substituted) dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and dioxin-like polychlorinated biphenyls (PCBs) were measured in maternal and fetal blood, and amniotic and allantoic fluids in cattle. Total toxicity equivalent quantity (TEQ) was highest in amniotic fluid on a fat-weight basis, whereas it was highest in maternal blood on a total weight basis. TEQ was lowest in allantoic fluid on either basis; 26 of 29 congeners analyzed in this experiment were detected in one or more samples. The largest number of congeners was detected in amniotic fluid. O 8CDD, 2,3,4,7,8-P 5CDF and 2,3′,4,4′,5-P 5CB were the major congeners in PCDDs, PCDFs and PCBs, respectively. The O 8CDD concentration was higher in fetal blood than in maternal blood on a fat-weight basis, whereas concentrations of other congeners were lower in fetal blood than in maternal blood. Furthermore, on a fat-weight basis, the O 8CDD concentration was considerably higher in allantoic fluid compared with other samples. Concentrations of major PCB congeners were higher in amniotic fluid than in maternal and fetal blood on a fat-weight basis. In conclusion, it is suggested that lipophilic endocrine-disrupting chemicals contained in maternal blood are all transferred to the fetal circulation via the placenta in cattle. Furthermore, the results of this experiment imply that O 8CDD has different transportation systems from other dioxins in the circulation, and that a considerable amount of PCBs is excreted and accumulated in amniotic fluid during the fetal stage in cattle.

Original languageEnglish
Pages (from-to)247-254
Number of pages8
JournalReproductive Toxicology
Volume20
Issue number2
DOIs
Publication statusPublished - Jul 2005
Externally publishedYes

Fingerprint

Dioxins
Polychlorinated Biphenyls
Amniotic Fluid
Fetal Blood
Blood
Mothers
Fluids
Weights and Measures
Fats
Endocrine Disruptors
Toxicity
Polychlorinated Dibenzodioxins
Dibenzofurans
dibenzo(1,4)dioxin
Placenta
Experiments

Keywords

  • Cattle
  • Conceptus
  • Dioxin-like PCB
  • Environment
  • PCDD
  • PCDF
  • Placental transport
  • Pregnancy

ASJC Scopus subject areas

  • Toxicology

Cite this

Comparison of the concentrations of polychlorinated dibenzo-p-dioxins, dibenzofurans, and dioxin-like polychlorinated biphenyls in maternal and fetal blood, amniotic and allantoic fluids in cattle. / Hirako, Makoto; Aoki, Mari; Kimura, Koji; Hanafusa, Yasuko; Ishizaki, Hiroshi; Kariya, Yoshihiro.

In: Reproductive Toxicology, Vol. 20, No. 2, 07.2005, p. 247-254.

Research output: Contribution to journalArticle

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